Results 41 to 50 of about 15,096 (180)

Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus

mSphere
Serotype 3 (T3) strains of mammalian orthoreovirus (reovirus) spread to the central nervous system to infect the brain and cause lethal encephalitis in newborn mice.
Kira A. Griswold, Iaroslavna Vasylieva, Megan C. Smith, Kay L. Fiske, Olivia L. Welsh, Alexa N. Roth, Alan M. Watson, Simon C. Watkins, Danica M. Sutherland, Terence S. Dermody   +9 more
doaj   +1 more source

Bid regulates the pathogenesis of neurotropic reovirus.

PLoS Pathogens, 2010
Reovirus infection leads to apoptosis in both cultured cells and the murine central nervous system (CNS). NF-kappaB-driven transcription of proapoptotic cellular genes is required for the effector phase of the apoptotic response.
Pranav Danthi, Andrea J Pruijssers, Angela K Berger, Geoffrey H Holm, Sandra S Zinkel, Terence S Dermody   +5 more
doaj   +1 more source

Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway

Journal of Translational Medicine, 2021
Background Cetuximab has been approved for use for first-line treatment of patients with wild-type KRAS metastatic colorectal cancer (CRC). However, treatment with cetuximab has shown limited efficacy as a CRC monotherapy. In addition, natural killer (NK)
Shiqi Long, Yangzhuo Gu, Yuanyuan An, Xiaojin Lin, Xiaoqing Chen, Xianyao Wang, Chunxiang Liao, Weiwei Ouyang, Nianxue Wang, Zhixu He, Xing Zhao   +10 more
doaj   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source

The Interplay of Reovirus with Autophagy [PDF]

BioMed Research International, 2014
Autophagy participates in multiple fundamental physiological processes, including survival, differentiation, development, and cellular homeostasis. It eliminates cytoplasmic protein aggregates and damaged organelles by triggering a series of events: sequestering the protein substrates into double-membrane vesicles, fusing the vesicles with lysosomes ...
Hung-Chuan Chiu, Sarah Richart, Fong-Yuan Lin, Wei-Li Hsu, Hung-Jen Liu   +4 more
openaire   +2 more sources

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Reovirus Cell Entry Requires Functional Microtubules

mBio, 2013
Mammalian reovirus binds to cell-surface glycans and junctional adhesion molecule A and enters cells by receptor-mediated endocytosis in a process dependent on β1 integrin.
Bernardo A. Mainou, Paula F. Zamora, Alison W. Ashbrook, Daniel C. Dorset, Kwang S. Kim, Terence S. Dermody   +5 more
doaj   +1 more source

Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy

Viruses, 2021
Oncolytic reovirus preferentially targets and kills cancer cells via the process of oncolysis, and additionally drives clinically favorable antitumor T cell responses that form protective immunological memory against cancer relapse. This two-prong attack
Vishnupriyan Kumar, Michael A. Giacomantonio, Shashi Gujar   +2 more
doaj   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source