Results 61 to 70 of about 27,138 (209)

Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway

Journal of Translational Medicine, 2021
Background Cetuximab has been approved for use for first-line treatment of patients with wild-type KRAS metastatic colorectal cancer (CRC). However, treatment with cetuximab has shown limited efficacy as a CRC monotherapy. In addition, natural killer (NK)
Shiqi Long, Yangzhuo Gu, Yuanyuan An, Xiaojin Lin, Xiaoqing Chen, Xianyao Wang, Chunxiang Liao, Weiwei Ouyang, Nianxue Wang, Zhixu He, Xing Zhao   +10 more
doaj   +1 more source

Combination therapy with reovirus and anti-PD-1 blockade controls tumor growth through innate and adaptive immune responses. [PDF]

, 2016
Oncolytic reovirus can be delivered both systemically and intratumorally, in both pre-clinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and anti-tumor activity is directly ...
Coffey, M, Diaz, RM, Harrington, K, Ilett, E, Kottke, T, Melcher, A, Pandha, H, Parrish, C, Rajani, K, Shim, KG, Thompson, J, Vile, R, Zaidi, S   +12 more
core   +1 more source

The First Report of Cod Gill Poxvirus in Gills of Atlantic Cod (Gadus morhua L.) Suffering From Cardiorespiratory Disease

Journal of Fish Diseases, Volume 48, Issue 4, April 2025.
ABSTRACT Atlantic cod farming experiences renewed growth in Norway, and increased awareness is essential to address emerging diseases in this species. There are few reports on gill diseases in cod, and to date, no viral gill infections of cod have been documented. In this study, we collected samples from three sequential time points in summer 2023 from
Mona C. Gjessing, Torstein Tengs, Hanne Nilsen, Saima Mohammad, Simon C. Weli   +4 more
wiley   +1 more source

Incidência de reovírus em algumas cidades do Rio Grande do Sul Incidence of haemagglutination inhibiting antibodies against reovirus in some cities of State of Rio Grande do Sul

Revista do Instituto de Medicina Tropical de São Paulo, 1984
Amostras de soros humanos coletadas nas cidades de Pelotas, Santiago e Uruguaiana, no Estado do Rio Grande do Sul, foram testadas para anticorpos inibidores da hemaglutinação contra reovírus.
Ivo Gomes de Mattos, Inguelore S. de Souza, Telmo Vidor   +2 more
doaj  

2224 Determining if intestinal commensal bacteria enhance the frequency of reassortment of an enteric, segmented virus, reovirus

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: The overall goal is to determine if intestinal commensal bacteria play a role in enteric virus evolution. We will use reovirus, an enteric segmented virus, to investigate specific goals.
Matthew Lanahan, Andrea Erickson, Julie Pfeiffer   +2 more
doaj   +1 more source

Removal of double-stranded contaminants from RNA transcripts: synthesis of adenovirus VA RNAI from a T7 vector [PDF]

, 1990
Bacteriophage RNA polymerases are widely used to synthesize defined RNAs on a large scale in vitro. Unfortunately, the RNA product contains a small proportion of contaminating RNAs, including complementary species, which can lead to errors of ...
Mellits, K. H., Pe'ery, T., Manche, L., Robertson, H. D., Mathews, M. B.   +4 more
core   +1 more source

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 12, Page 3252-3267, 15 June 2026.
What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Karen J. Scott, Emma J. West, Rebecca J. Brownlie, Fay Ismail, Christy Ralph, Thomas Heineman, Matt Coffey, Alan A. Melcher, Alison Taylor, Salvatore Papa, Adel Samson   +10 more
wiley   +1 more source

Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer [PDF]

, 2018
Objective: Oncolytic viruses (OVs) represent promising, proinflammatory cancer treatments. Here, we explored whether OV-induced innate immune responses could simultaneously inhibit HCV while suppressing hepatocellular carcinoma (HCC).
Abigail Bloy, Adam Peckham-Cooper, Adel Samson, Alan Melcher, Elizabeth Appleton, Fiona Errington-Mais, Franssen, Gerard Nuovo, Giles Toogood, Hagan, Hsu, Jebar, Karen Scott, Kevin Harrington, Lao, Matthew Coffey, Matthew J Bentham, Peter Selby, Rajiv Dave, Reig, Richard Vile, Robert A Adair, Seishi Nagamori, Stephen Griffin, Utsunomiya, Yamashita   +25 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, Volume 16, Issue 4, Page 653-669, April 2026.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer

Nature Communications
The route of oncolytic virotherapy is pivotal for immunotherapeutic efficacy in advanced cancers. In this preclinical study, an oncolytic reovirus (RC402) is orally administered to induce antitumor immunity.
Won Suk Lee, Seung Joon Lee, Hye Jin Lee, Hannah Yang, Eun-Jin Go, Enkhtaivan Gansukh, Ki-Hoon Song, Xiao Xiang, Dong Guk Park, Tommy Alain, Hong Jae Chon, Chan Kim   +11 more
doaj   +1 more source