Results 71 to 80 of about 18,162 (217)
Virion Disassembly Is Required for Apoptosis Induced by Reovirus [PDF]
, 2002 Reovirus infection leads to apoptosis in cultured cells and in vivo. Binding of viral attachment protein ς1 to both sialic acid and junction adhesion molecule is required for induction of apoptosis.
Terence S. Dermody, Jodi L. Connolly
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Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer
Nature CommunicationsThe route of oncolytic virotherapy is pivotal for immunotherapeutic efficacy in advanced cancers. In this preclinical study, an oncolytic reovirus (RC402) is orally administered to induce antitumor immunity.
Won Suk Lee +11 more
doaj +1 more source
Reovirus directly engages integrin to recruit clathrin for entry into host cells
Nature Communications, 2021 Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via ...
Melanie Koehler +9 more
doaj +1 more source
Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong +3 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, Volume 13, Issue 38, 9 July 2026.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer
Molecular Therapy: Oncolytics, 2020 Breast cancer is the second leading cause of cancer-related deaths in women in the United States. The triple-negative breast cancer (TNBC) subtype associates with higher rates of relapse, shorter overall survival, and aggressive metastatic disease ...
Jameson T.L. Berry +4 more
doaj +1 more source
Application of Microbial and Parasitology Techniques for Diagnosis in Laboratory Rodents
Current Protocols, Volume 6, Issue 7, July 2026.Abstract Pathogen diagnosis in rodents through effective health monitoring programs is essential for maintaining high welfare and standards in laboratory animal facilities. Although many animal facilities are increasingly adopting real‐time polymerase chain reaction testing of environmental or filter samples for pathogen detection, thereby reducing the
Debora Rapaport +2 more
wiley +1 more source
Viral gene expression potentiates reovirus-induced necrosis [PDF]
, 2015 Infection of some cell types by reovirus evokes a caspase-independent form of cell death resembling necrosis. While reovirus strain T3D induces necrosis much more efficiently than strain T1L, which viral components contribute to this difference is not ...
Danthi, Pranav +2 more
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Reovirus and tumor oncolysis [PDF]
, 2007 REOviruses (Respiratory Enteric Orphan viruses) are ubiquitous, non-enveloped viruses containing 10 segments of double-stranded RNA (dsRNA) as their genome.
Manbok Kim +2 more
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