Results 71 to 80 of about 19,955 (213)
Reovirus Receptors and Apoptosis
Virology, 2001 The mammalian reoviruses are a tractable experimental system for studies of viral replication and pathogenesis. Reovirus virions are nonenveloped, double-shelled particles containing a genome of 10 segments of doublestranded RNA (Nibert and Schiff, 2001).
Barton, Erik S. +4 more
openaire +2 more sources
Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong +3 more
wiley +1 more source
The Nogo Receptor NgR1 Mediates Infection by Mammalian Reovirus [PDF]
, 2014 SummaryNeurotropic viruses, including mammalian reovirus, must disseminate from an initial site of replication to the central nervous system (CNS), often binding multiple receptors to facilitate systemic spread.
Sekine, Yuichi +5 more
core +1 more source
Virology Journal, 2005 Background Mammalian reoviruses naturally infect their hosts through the enteric and respiratory tracts. During enteric infections, proteolysis of the reovirus outer capsid protein σ3 is mediated by pancreatic serine proteases. In contrast, the proteases
Schiff Leslie A, Golden Joseph W
doaj +1 more source
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer
Molecular Therapy: Oncolytics, 2020 Breast cancer is the second leading cause of cancer-related deaths in women in the United States. The triple-negative breast cancer (TNBC) subtype associates with higher rates of relapse, shorter overall survival, and aggressive metastatic disease ...
Jameson T.L. Berry +4 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley +1 more source
Multi-organ lesions in suckling mice infected with SARS-associated mammalian reovirus linked with apoptosis induced by viral proteins μ1 and σ1. [PDF]
PLoS ONE, 2014 We reported the isolation and characterization of a novel mammalian reassortant reovirus BYD1 that may have played an accomplice role with SARS-coronavirus during the 2003 SARS pandemic.
Lihua Song +7 more
doaj +1 more source
Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2548-2576, August 2026.This review summarizes the discovery, biosynthesis, and transport of strigolactone, and the D14‐D3/MAX2‐D53/SMXLs signaling module. It highlights diverse roles of strigolactone in plant architecture, stress responses, and crop breeding, including species‐specific functions, hormonal crosstalk, and agricultural applications.
Qingliang Hu, Jiayang Li, Bing Wang
wiley +1 more source
Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. [PDF]
PLoS Pathogens, 2015 Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases ...
Joshua D Doyle +7 more
doaj +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, Volume 13, Issue 38, 9 July 2026.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source