Results 51 to 60 of about 18,162 (217)

Reovirus RNAs and proteins are generated simultaneously. [PDF]

, 2022
(A-B) L929 cells were infected with reovirus at an MOI of 3 with or without cycloheximide (100μg/mL) and samples were collected every 3 hours to measure virus mRNA and protein levels.
Justine Kniert (13783400), Greg Plummer (13783409), Maya Shmulevitz (102544), Theodore dos Santos (13783403), Heather E. Eaton (9402228), Woo Jung Cho (13783406)   +5 more
core   +1 more source

Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus

mSphere
Serotype 3 (T3) strains of mammalian orthoreovirus (reovirus) spread to the central nervous system to infect the brain and cause lethal encephalitis in newborn mice.
Kira A. Griswold, Iaroslavna Vasylieva, Megan C. Smith, Kay L. Fiske, Olivia L. Welsh, Alexa N. Roth, Alan M. Watson, Simon C. Watkins, Danica M. Sutherland, Terence S. Dermody   +9 more
doaj   +1 more source

Common evolutionary origin of aquareoviruses and orthoreoviruses revealed by genome characterization of Golden shiner reovirus, Grass carp reovirus, Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family Reoviridae) [PDF]

, 2002
Full-length and partial genome sequences of four members of the genus Aquareovirus, family Reoviridae (Golden shiner reovirus, Grass carp reovirus, Striped bass reovirus and golden ide reovirus) were characterized.
Xavier de Lamballerie, Philippe Biagini, Qin Fang, Attoui, H, Univ Mediterranee, Fac Med Marseille, EFS Alpes Mediterranee, Unite Virus Emergents,EA3292, F-13005 Marseille, France, Philippe de Micco, Houssam Attoui, Jean-François Cantaloube, Fauziah Mohd Jaafar   +7 more
core  

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

The Interplay of Reovirus with Autophagy [PDF]

BioMed Research International, 2014
Autophagy participates in multiple fundamental physiological processes, including survival, differentiation, development, and cellular homeostasis. It eliminates cytoplasmic protein aggregates and damaged organelles by triggering a series of events: sequestering the protein substrates into double-membrane vesicles, fusing the vesicles with lysosomes ...
Hung-Chuan Chiu, Sarah Richart, Fong-Yuan Lin, Wei-Li Hsu, Hung-Jen Liu   +4 more
openaire   +2 more sources

PKR, Myocarditis and the Cardiac Response to Reovirus Infection [PDF]

, 2004
Viral myocarditis is an important human disease associated with many viruses. Mechanistically, cardiac damage associated with viral myocarditis can be immune mediated and/or the result of direct cytopathic effect.
Stewart, Michael Jude
core  

Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway

Journal of Translational Medicine, 2021
Background Cetuximab has been approved for use for first-line treatment of patients with wild-type KRAS metastatic colorectal cancer (CRC). However, treatment with cetuximab has shown limited efficacy as a CRC monotherapy. In addition, natural killer (NK)
Shiqi Long, Yangzhuo Gu, Yuanyuan An, Xiaojin Lin, Xiaoqing Chen, Xianyao Wang, Chunxiang Liao, Weiwei Ouyang, Nianxue Wang, Zhixu He, Xing Zhao   +10 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Oncolytic Reovirus Induces Intracellular Redistribution of Ras to Promote Apoptosis and Progeny Virus Release [PDF]

, 2014
Ras is a dynamic protein capable of interacting with plasma membrane microdomains and intracellular membranes. Its activity, as controlled by post-translational modifications, is essential in regulating cell growth, differentiation, and death ...
Garant, Katy
core