Results 81 to 90 of about 19,955 (213)
Application of Microbial and Parasitology Techniques for Diagnosis in Laboratory Rodents
Current Protocols, Volume 6, Issue 7, July 2026.Abstract Pathogen diagnosis in rodents through effective health monitoring programs is essential for maintaining high welfare and standards in laboratory animal facilities. Although many animal facilities are increasingly adopting real‐time polymerase chain reaction testing of environmental or filter samples for pathogen detection, thereby reducing the
Debora Rapaport +2 more
wiley +1 more source
Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer
BMC Cancer, 2011 Background Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in vitro, in in vivo murine models and in early clinical trials. However the true potential of oncolytic viruses may only be realized fully in combination with other modalities ...
Prestwich Robin +10 more
doaj +1 more source
Natural Sciences, Volume 6, Issue 3, July 2026.An interrogation of T. S. Kuhn's dichotomy between Normal and Revolutionary Science through close inside examinations of three paradigm‐changing advances in molecular biology and immunology of the past 50 years. ABSTRACT The past 60 years have seen explosive changes in the fields of molecular biology and immunology that now affect clinical medicine as ...
Ellen V. Rothenberg
wiley +1 more source
Cancer Science, Volume 117, Issue 7, Page 2007-2020, July 2026.OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan +8 more
wiley +1 more source
Viral gene expression potentiates reovirus-induced necrosis [PDF]
, 2015 Infection of some cell types by reovirus evokes a caspase-independent form of cell death resembling necrosis. While reovirus strain T3D induces necrosis much more efficiently than strain T1L, which viral components contribute to this difference is not ...
Danthi, Pranav +2 more
core +1 more source
NKp46 Recognizes the Sigma1 Protein of Reovirus: Implications for Reovirus-Based Cancer Therapy
, 2017 The recent approval of oncolytic virus for therapy of melanoma patients has increased the need for precise evaluation of the mechanisms by which oncolytic viruses affect tumor growth.
Alexandra Duev-Cohen +8 more
core +1 more source
Host and Viral Determinants of Reovirus Oncolysis [PDF]
, 2018 Mammalian orthoreovirus (reovirus) is a non-pathogenic virus that naturally infects through the enteric and respiratory routes. Reoviruses are non-enveloped and have a 10-segment double stranded RNA (dsRNA) genome encased in 2 concentric capsid shells ...
Mohamed, Adil SG
core +1 more source
Reovirus RNAs and proteins are generated simultaneously.
, 2022 (A-B) L929 cells were infected with reovirus at an MOI of 3 with or without cycloheximide (100μg/mL) and samples were collected every 3 hours to measure virus mRNA and protein levels.
Justine Kniert (13783400) +5 more
core +1 more source
Reovirus type 1 associated with meningitis
, 1996 A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy.
Svensson, Lennart +5 more
core +2 more sources
Attenuated reovirus displays oncolysis with reduced host toxicity [PDF]
, 2010 BackgroundAlthough the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells.
N I zur Nieden +19 more
core +1 more source