Results 81 to 90 of about 18,162 (217)
Avian reovirus-triggered apoptosis enhances both virus spread and the processing of the viral nonstructural muNS protein [PDF]
, 2014 Avian reovirus non-structural protein muNS is partially cleaved in infected chicken embryo fibroblast cells to produce a 55-kDa carboxyterminal protein, termed muNSC, and a 17-kDa aminoterminal polypeptide, designated muNSN.
Rodríguez Grille, Javier +11 more
core +1 more source
Virology Journal, 2005 Background Mammalian reoviruses naturally infect their hosts through the enteric and respiratory tracts. During enteric infections, proteolysis of the reovirus outer capsid protein σ3 is mediated by pancreatic serine proteases. In contrast, the proteases
Schiff Leslie A, Golden Joseph W
doaj +1 more source
Multi-organ lesions in suckling mice infected with SARS-associated mammalian reovirus linked with apoptosis induced by viral proteins μ1 and σ1. [PDF]
PLoS ONE, 2014 We reported the isolation and characterization of a novel mammalian reassortant reovirus BYD1 that may have played an accomplice role with SARS-coronavirus during the 2003 SARS pandemic.
Lihua Song +7 more
doaj +1 more source
Natural Sciences, Volume 6, Issue 3, July 2026.An interrogation of T. S. Kuhn's dichotomy between Normal and Revolutionary Science through close inside examinations of three paradigm‐changing advances in molecular biology and immunology of the past 50 years. ABSTRACT The past 60 years have seen explosive changes in the fields of molecular biology and immunology that now affect clinical medicine as ...
Ellen V. Rothenberg
wiley +1 more source
The structure of reovirus [PDF]
, 1982 The arrangement of the capsomers comprising the outer shell or capsid of reovirus has been determined by the computer modeling of images of reovirus replicas prepared by freeze-etching techniques.
Metcalf, Peter
core
Host and Viral Determinants of Reovirus Oncolysis [PDF]
, 2018 Mammalian orthoreovirus (reovirus) is a non-pathogenic virus that naturally infects through the enteric and respiratory routes. Reoviruses are non-enveloped and have a 10-segment double stranded RNA (dsRNA) genome encased in 2 concentric capsid shells ...
Mohamed, Adil SG
core +2 more sources
Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer
BMC Cancer, 2011 Background Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in vitro, in in vivo murine models and in early clinical trials. However the true potential of oncolytic viruses may only be realized fully in combination with other modalities ...
Prestwich Robin +10 more
doaj +1 more source
Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. [PDF]
PLoS Pathogens, 2015 Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases ...
Joshua D Doyle +7 more
doaj +1 more source
Cancer Science, Volume 117, Issue 7, Page 2007-2020, July 2026.OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source