Results 101 to 110 of about 18,162 (217)

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine.

PLoS ONE
Oncolytic reovirus is a potential therapeutic for colorectal cancer patients with a mutant KRAS gene. Reovirus hijacks the autophagic machinery and preferentially induces apoptosis in patients with a KRAS mutation.
Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra   +4 more
doaj   +1 more source

Endothelial JAM-A Facilitates Reovirus Bloodstream Spread [PDF]

, 2013
Bloodstream spread is an essential step in the pathogenesis of many viruses. However, mechanisms that promote viremia are not well understood. Reoviruses are neurotropic viruses that disseminate systemically through the circulatory system.
Lai, Caroline Ming-Hwei
core  

WGA inhibits binding of reovirus to cells. [PDF]

, 2012
(A) Detection of Sialic acids in cell lines (911, CHO, U118MG and Lec2) by FITC-labeled WGA immunofluorescence. (B) WGA inhibition of reovirus infection.
Raoul J. de Groot (127117), Rob C. Hoeben (124103), Iris J. C. Dautzenberg (127112), Sanne K. van den Hengel (127114), Steve J. Cramer (124095), Diana J. M. van den Wollenberg (127110)   +5 more
core   +1 more source

Reovirus type 2 in domestic cats:isolation and experimental transmission [PDF]

, 1992
Five reovirus isolates were recovered in MA104 cell cultures from the faeces of three cats with nictitating membrane protrusion and diarrhoea, one cat with diarrhoea only and from one healthy cat.
Gruffydd-Jones, Timothy J, Harbour, David A, Muir, P   +2 more
core   +1 more source

Amino acid differences in reovirus proteins of the jin mutants and the wt T3D reovirus strain. [PDF]

, 2012
Amino acid differences in reovirus proteins of the jin mutants and the wt T3D reovirus strain.
Raoul J. de Groot (127117), Rob C. Hoeben (124103), Iris J. C. Dautzenberg (127112), Sanne K. van den Hengel (127114), Steve J. Cramer (124095), Diana J. M. van den Wollenberg (127110)   +5 more
core   +1 more source

The cytotoxicity of ultraviolet light irradiated reovirus [PDF]

, 1971
When reovirus type 2 was exposed to ultraviolet light (UV) for 2-5 minutes, it acquired a cytotoxic property to HeLa cells. Maximal toxicity was attained after 10 minutes irradiation and decreased to undetectable levels by 60 minutes.
Subasinghe, Don Henry Ariyadasa
core  

Mammalian orthoreovirus can exit cells in extracellular vesicles.

PLoS Pathogens
Several egress pathways have been defined for many viruses. Among these pathways, extracellular vesicles (EVs) have been shown to function as vehicles of non-lytic viral egress.
Sydni Caet Smith, Evan Krystofiak, Kristen M Ogden   +2 more
doaj   +1 more source

Functional Domains of Reovirus Protein μ2 that Determine the Interferon Response and Reovirus Replication [PDF]

, 2011
The innate immune system provides a critical first line of protection against invading pathogens. In particular, the type I interferon (IFN) response enables the host to establish an antiviral state upon infection. Reovirus infection in vitro and in vivo
Irvin, Susan C.
core  

Isolation and identification of a novel goose-origin reovirus GD218 and its pathogenicity experiments

Frontiers in Veterinary Science
Since 2020, a novel goose-derived reovirus, characterized by goose hemorrhagic hepatitis, has emerged in the goose breeding industry of Guangdong province, China, leading to significant economic losses in the poultry sector.
Yuze Li, Huihu Yang, Yongkun Lu, Zhenghao Yin, Hang Xu, Kun Mei, Shujian Huang   +6 more
doaj   +1 more source

Junctional Adhesion Molecule-A and Reovirus Pathogenesis [PDF]

, 2008
Diverse families of viruses bind immunoglobulin superfamily (IgSF) proteins located in tight junctions and adherens junctions of epithelium and endothelium. However, little is known about the roles of these receptors in the pathogenesis of viral disease.
Antar, Annukka Aida Rose
core