Results 111 to 120 of about 34,332 (263)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Reovirus σNS and μNS Proteins Remodel the Endoplasmic Reticulum to Build Replication Neo-Organelles

mBio, 2018
Like most viruses that replicate in the cytoplasm, mammalian reoviruses assemble membranous neo-organelles called inclusions that serve as sites of viral genome replication and particle morphogenesis.
R. Tenorio, Isabel Fernández de Castro, J. J. Knowlton, Paula F. Zamora, Christopher H. Lee, Bernardo A. Mainou, T. Dermody, C. Risco   +7 more
semanticscholar   +1 more source

Evidence that avian reovirus σNS is an RNA chaperone: implications for genome segment assortment. [PDF]

, 2015
Reoviruses are important human, animal and plant pathogens having 10-12 segments of double-stranded genomic RNA. The mechanisms controlling the assortment and packaging of genomic segments in these viruses, remain poorly understood.
Ault, J, Borodavka, A, Stockley, PG, Tuma, R   +3 more
core   +1 more source

Effect of medicinal and food homologous plants polysaccharides on animal nutrition and health: A review

Food Biomacromolecules, Volume 3, Issue 1, Page 5-23, March 2026.
Abstract As one of the most important components of foods, animal meat provides a lot of protein, fat, and energy for humans. However, nutrition and health of animals directly affect the healthiness of human, especially antibiotic residues in animals induced by abuse of antibiotics.
Zichao Wang, Yi Zheng, Changxing Liu, Danye Zhu, Yingjie Feng, Hongtao Zhang, Qi Wang, Qinggong Chen, Xueyi Qiao   +8 more
wiley   +1 more source

Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells

Virology Journal, 2005
Background Mammalian reoviruses naturally infect their hosts through the enteric and respiratory tracts. During enteric infections, proteolysis of the reovirus outer capsid protein σ3 is mediated by pancreatic serine proteases. In contrast, the proteases
Schiff Leslie A, Golden Joseph W
doaj   +1 more source

25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection

Journal of Virology, 2018
The innate immune system is crucial for effective responses to viral infection. Type I interferons, central components of innate immunity, induce expression of hundreds of ISGs; however, the mechanisms of action of these antiviral proteins are not well ...
Alexandra G Doms, Tatiana Sanabria, J. Hansen, N. Altan-Bonnet, Geoffrey H. Holm   +4 more
semanticscholar   +1 more source

Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase [PDF]

, 1990
Transcription from the human immunodeficiency virus type 1 promoter gives rise to short cytoplasmic transcripts of approximately 60 nucleotides as well as to longer mRNAs.
Gunnery, S., Rice, A. P., Robertson, H. D., Mathews, M. B.   +3 more
core   +1 more source

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, Volume 3, Issue 1, March 2026.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer

BMC Cancer, 2011
Background Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in vitro, in in vivo murine models and in early clinical trials. However the true potential of oncolytic viruses may only be realized fully in combination with other modalities ...
Prestwich Robin, Melcher Alan, Vile Richard, Relph Kate L, Kottke Timothy, Boxall Angela, Simpson Guy R, Heinemann Lucy, Harrington Kevin J, Morgan Richard, Pandha Hardev S   +10 more
doaj   +1 more source

Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. [PDF]

PLoS Pathogens, 2015
Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases ...
Joshua D Doyle, Jennifer E Stencel-Baerenwald, Courtney A Copeland, Jillian P Rhoads, Judy J Brown, Kelli L Boyd, James B Atkinson, Terence S Dermody   +7 more
doaj   +1 more source