Results 1 to 10 of about 9,793 (243)

Negri bodies are viral factories with properties of liquid organelles [PDF]

Nature Communications, 2017
Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the ...
Jovan Nikolic, Romain Le Bars, Zoé Lama, Nathalie Scrima, Cécile Lagaudrière-Gesbert, Yves Gaudin, Danielle Blondel   +6 more
doaj   +8 more sources

Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]

PLoS ONE, 2013
BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj   +10 more sources

Formation and Function of Liquid-Like Viral Factories in Negative-Sense Single-Stranded RNA Virus Infections [PDF]

Viruses, 2021
Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to organize intracellular membrane-less structures. Studies with non-segmented negative-sense (NNS) RNA viruses have uncovered a key role of LLPS in the formation of viral ...
Justin M. Su, Maxwell Z. Wilson, Charles E. Samuel, Dzwokai Ma   +3 more
doaj   +7 more sources

Evaluation of Viral Genome Copies Within Viral Factories on Different DNA Viruses [PDF]

Journal of Histochemistry and Cytochemistry, 2018
Summary This article describes a simple method of measuring the number of viral genomes within viral factories. For this purpose, we use three DNA viruses replicating in the cytoplasm of the infected cells: wild-type African swine fever virus (ASFV)-Georgia 2007, culture-adapted type ASFV-BA71V, and Vaccinia virus (VV).
Karalyan ZA, Izmailyan RA, Abroyan LO, Avetisyan AS, Hakobyan LA, Zakaryan HS, Karalova EM.   +6 more
exaly   +7 more sources

Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories

Nature Communications, 2023
Ebola virus (EBOV) infection induces the formation of membrane-less, cytoplasmic compartments termed viral factories, in which multiple viral proteins gather and coordinate viral transcription, replication, and assembly.
Jingru Fang, Guillaume Castillon, Sebastien Phan, Sara McArdle, Chitra Hariharan, Aiyana Adams, Mark H. Ellisman, Ashok A. Deniz, Erica Ollmann Saphire   +8 more
doaj   +4 more sources

Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories [PDF]

Journal of Virology, 2019
Rotavirus (RV) replicates in round-shaped cytoplasmic viral factories, although how they assemble remains unknown. During RV infection, NSP5 undergoes hyperphosphorylation, which is primed by the phosphorylation of a single serine residue.
Guido Papa, Alexander Borodavka, Catherine Eichwald   +2 more
exaly   +5 more sources

Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories [PDF]

Journal of Virology
Early in infection, mammalian orthoreoviruses (reoviruses) build neo-organelles called viral factories (VFs). These structures incorporate fragments of endoplasmic reticulum (ER) and serve as sites of viral genome replication and particle assembly.
Raquel Tenorio, Gwen M. Taylor, Ana Cayuela, C. O. S. Sorzano, Isabel Fernández de Castro, Sara Y. Fernández-Sánchez, Alexa N. Roth, Xayathed Somoulay, Gavin S. Treadaway, Terence S. Dermody, Cristina Risco   +10 more
doaj   +2 more sources

Mimivirus transcription and translation occur at well-defined locations within amoeba host cells [PDF]

Journal of Virology
Many giant viruses replicate in the cytoplasm in viral factories. How exactly these viral factories are established and where the different steps of the replication cycle occur remain largely obscure.
Lotte Mayer, Georgi Nikolov, Martin Kunert, Matthias Horn, Anouk Willemsen   +4 more
doaj   +2 more sources

Chromatin assembly by the histone chaperone HIRA facilitates Human Papillomavirus replication [PDF]

Tumour Virus Research
The circular, double-stranded DNA genomes of Human papillomaviruses (HPV) exist in a nucleosomal state throughout the infectious cycle and rely on host histone epigenetic modifications and chromatin assembly processes to promote various phases of the ...
Ashley N. Della Fera, Dan Chen, Alison A. McBride   +2 more
doaj   +2 more sources

Spatiotemporal coordination of reovirus peripheral core replication to perinuclear whole virus assembly. [PDF]

PLoS Pathogens
Reoviruses coordinate their replication and assembly through intricate spatial and temporal compartmentalization within host cells. In this study, we elucidate the dynamics of mammalian orthoreovirus (reovirus) core replication and viral particle ...
Justine Kniert, Dante Terino, Heather E Eaton, Qi Feng Lin, Shiau-Yin Wu, Hilmar Strickfaden, Maya Shmulevitz   +6 more
doaj   +2 more sources