Results 1 to 10 of about 1,104,882 (91)
Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories
Nature Communications, 2023 Ebola virus (EBOV) infection induces the formation of membrane-less, cytoplasmic compartments termed viral factories, in which multiple viral proteins gather and coordinate viral transcription, replication, and assembly.
Jingru Fang +8 more
doaj +4 more sources
Viruses, 2021 Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to organize intracellular membrane-less structures. Studies with non-segmented negative-sense (NNS) RNA viruses have uncovered a key role of LLPS in the formation of viral ...
Justin M. Su +3 more
doaj +4 more sources
Negri bodies are viral factories with properties of liquid organelles
Nature Communications, 2017 Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the ...
Jovan Nikolic +6 more
doaj +4 more sources
Microbiology Spectrum, 2023 In addition to the 3′-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5′-poly(A) leader that confers a translational advantage in virally infected cells.
Pragyesh Dhungel +2 more
doaj +3 more sources
Advanced Materials, 2022 Viral factories are intracellular microcompartments formed by mammalian viruses in their host cells, and contain necessary machinery for viral genome replication, capsid assembly, and maturation, thus serving as “factories” for formation of new viral ...
Itai Katzir, Elvira Haimov, A. Lampel
semanticscholar +3 more sources
Proceedings, 2020 Viruses remodel cellular compartments to build their replication factories. Remarkably, viruses are also able to induce new membranes and new organelles.
Cristina Risco Ortiz
doaj +2 more sources
Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]
PLoS ONE, 2013 BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj +3 more sources
Reovirus inhibits interferon production by sequestering IRF3 into viral factories
Scientific Reports, 2017 Upon viral infection, an arms-race between the cellular intrinsic innate immune system and viral replication is established. To win this race, viruses have established multiple strategies to inhibit the cellular response.
M. Stanifer +4 more
semanticscholar +4 more sources
Capping pores of alphavirus nsP1 gate membranous viral replication factories
Nature, 2020 Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and alphaviruses, carry out transcription and replication inside virus-induced membranous organelles within host cells 1 – 7 .
Rhian Jones +3 more
semanticscholar +4 more sources
VirologyCytosolic viral factories (VFs) of mammalian orthoreovirus (MRV) are sites for viral genome replication and assembly of virus progeny. Despite advancements in reverse genetics, the formation and dynamics of VFs still need to be clarified.
Melissa Lee, Janine Vetter, C. Eichwald
semanticscholar +3 more sources