Results 11 to 20 of about 1,732,794 (242)

Selective recruitment of nucleoporins on vaccinia virus factories and the role of Nup358 in viral infection.

Virology, 2017
Vaccinia virus (VACV), a member of the Poxviridae family, uses cytoplasmic factories for its replication. Recent studies indicated that VACV infection requires a set of nucleoporins. However, how the nucleoporins contribute to viral life cycle remains unclear.
D. Khuperkar, A. Kamble, Aditi Singh, Arya Ghate, Renuka Nawadkar, A. Sahu, Jomon Joseph   +6 more
semanticscholar   +6 more sources

Structure of orthoreovirus RNA chaperone σNS, a component of viral replication factories

Nature Communications, 2023
The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication compartments that support viral genome replication and capsid assembly. Despite its functional importance, a mechanistic understanding of σNS is lacking.
Boyang Zhao, Liya Hu, Soni Kaundal, Neetu Neetu, Christopher H. Lee, Xayathed Somoulay, Banumathi Sankaran, Gwen M. Taylor, Terence S. Dermody, B. V. Venkataram Prasad   +9 more
doaj   +7 more sources

Recruitment of Cellular Clathrin to Viral Factories and Disruption of Clathrin-Dependent Trafficking [PDF]

Traffic, 2011
The viral factories of mammalian reovirus (MRV) are cytoplasmic structures that serve as sites of viral genome replication and particle assembly. A 721‐aa MRV non‐structural protein, µNS, forms the factory matrix and recruits other viral proteins to ...
T. Ivanović, S. Boulant, M. Ehrlich, Aleksander A. Demidenko, M. Arnold, T. Kirchhausen, M. Nibert   +6 more
semanticscholar   +5 more sources

Evaluation of Viral Genome Copies Within Viral Factories on Different DNA Viruses [PDF]

Journal of Histochemistry & Cytochemistry, 2018
Summary This article describes a simple method of measuring the number of viral genomes within viral factories. For this purpose, we use three DNA viruses replicating in the cytoplasm of the infected cells: wild-type African swine fever virus (ASFV)-Georgia 2007, culture-adapted type ASFV-BA71V, and Vaccinia virus (VV).
Z. Karalyan, Roza Izmailyan, L. Abroyan, A. Avetisyan, L. A. Hakobyan, H. Zakaryan, E. Karalova   +6 more
semanticscholar   +4 more sources

The dynamics of both filamentous and globular mammalian reovirus viral factories rely on the microtubule network.

Virology, 2018
Mammalian reovirus viral factories (VFs) form filamentous or globular structures depending on the viral strain. In this study, we attempt to characterize the dynamics of both filamentous and globular VFs. Here, we present evidence demonstrating that globular VFs are dynamic entities coalescing between them, thereby gaining in size and concomitantly ...
C. Eichwald, M. Ackermann, M. Nibert
semanticscholar   +7 more sources

Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories [PDF]

Frontiers in Microbiology, 2022
Hepatitis E virus (HEV) is the major cause of acute hepatitis worldwide. HEV is a positive-sense RNA virus expressing three open reading frames (ORFs).
K. Metzger, Cyrine Bentaleb, K. Hervouet, V. Alexandre, C. Montpellier, Jean-Michel Saliou, Martin Ferrié, Charline Camuzet, Y. Rouillé, C. Lecoeur, J. Dubuisson, L. Cocquerel, C. Aliouat-Denis   +12 more
semanticscholar   +6 more sources

Nucleocytoviricota viral factories are transient organelles made by liquid-liquid phase separation

bioRxiv
Phase separation is a widespread mechanism in viral processes, mediating replication, host manipulation and virion morphogenesis. The phylum Nucleocytoviricota encompasses diverse and ubiquitous viruses, including Poxviridae, the climate-modulating ...
Sofia Rigou, Alain Schmitt, Anaísa B. Moreno, A. Lartigue, Lucile Danner, Claire Giry, Feres Trabelsi, L. Belmudes, Natalia Olivero-Deibe, Hugo Le Guenno, Y. Couté, Mabel Berois, M. Legendre, Sandra Jeudy, Chantal Abergel, Hugo Bisio   +15 more
semanticscholar   +2 more sources

Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories

Journal of Virology, 2019
The rotavirus (RV) double-stranded RNA genome is replicated and packaged into virus progeny in cytoplasmic structures termed viroplasms. The nonstructural protein NSP5, which undergoes a complex hyperphosphorylation process during RV infection, is ...
G. Papa, Luca Venditti, F. Arnoldi, E. Schraner, Christiaan A. Potgieter, A. Borodavka, C. Eichwald, O. Burrone   +7 more
semanticscholar   +3 more sources

Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories

Frontiers in Cellular and Infection Microbiology, 2022
The biology of the viral life cycle essentially includes two structural and functional entities—the viral genome and protein machinery constituting the viral arsenal and an array of host cellular components which the virus closely associates with—to ...
Pritam Chandra, Shreya Banerjee, P. Saha, M. Chawla-Sarkar, Upayan Patra   +4 more
semanticscholar   +3 more sources

Analysis of HDAC6 and BAG3-Aggresome Pathways in African Swine Fever Viral Factory Formation [PDF]

Viruses, 2015
African swine fever virus (ASFV) is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates and severe economic losses in pigs worldwide.
Raquel Muñoz-Moreno, Lucía Barrado-Gil, Inmaculada Galindo, Covadonga Alonso   +3 more
doaj   +4 more sources