Results 11 to 20 of about 9,793 (243)
Proceedings, 2020 Viruses remodel cellular compartments to build their replication factories. Remarkably, viruses are also able to induce new membranes and new organelles.
Cristina Risco Ortiz
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Reovirus inhibits interferon production by sequestering IRF3 into viral factories [PDF]
Scientific Reports, 2017 AbstractUpon viral infection, an arms-race between the cellular intrinsic innate immune system and viral replication is established. To win this race, viruses have established multiple strategies to inhibit the cellular response. Mammalian reovirus (MRV) constitutes a great model to study pathogenesis and life cycle of dsRNA viruses.
Steeve Boulant +2 more
exaly +6 more sources
Rice stripe mosaic virus encoded phosphoprotein forms viral factory-like granules and is crucial for viral replication [PDF]
Phytopathology ResearchViral proteins can aggregate into granules within host cells, known as viral factories, or viroplasms, which play a pivotal role in facilitating viral replication and shielding the viral genome from cellular defense mechanisms.
Zhiyi Wang +7 more
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Recruitment of Cellular Clathrin to Viral Factories and Disruption of Clathrin‐Dependent Trafficking [PDF]
Traffic, 2011 The viral factories of mammalian reovirus (MRV) are cytoplasmic structures that serve as sites of viral genome replication and particle assembly. A 721‐aa MRV non‐structural protein, µNS, forms the factory matrix and recruits other viral proteins to these structures.
Steeve Boulant +2 more
exaly +5 more sources
Setting Up Shop: The Formation and Function of the Viral Factories of Cauliflower mosaic virus. [PDF]
Front Plant Sci, 2017 Similar to cells, viruses often compartmentalize specific functions such as genome replication or particle assembly. Viral compartments may contain host organelle membranes or they may be mainly composed of viral proteins. These compartments are often termed: inclusion bodies (IBs), viroplasms or viral factories.
Schoelz JE, Leisner S.
europepmc +7 more sources
Single- and/or double-membrane viral factories? [PDF]
International Journal of Virology Studies & Research, 2014 Once entering the cell host, viruses needs to interact with intracellular membranes in order to build up their replication organelles or factories, resulting in a remodeling of the cell membranes, the hallmark of virus infection. Positive (+) strand RNA viruses represent the largest group of RNA viruses.
Romero-Brey I
openaire +3 more sources
Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories. [PDF]
Front Microbiol, 2022 Hepatitis E virus (HEV) is the major cause of acute hepatitis worldwide. HEV is a positive-sense RNA virus expressing three open reading frames (ORFs). ORF1 encodes the ORF1 non–structural polyprotein, the viral replicase which transcribes the full-length genome and a subgenomic RNA that encodes the structural ORF2 and ORF3 ...
Metzger K +12 more
europepmc +9 more sources
Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy [PDF]
Journal of Visualized Experiments, 2018 It is well known that spatial and temporal regulation of genes is an integral part of governing proper gene expression. Consequently, it is invaluable to understand where and when transcription is taking place within nuclear space and to visualize the relationship between episomes infected within the same cell's nucleus.
Chen, Christopher P +2 more
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Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories. [PDF]
PLoS Pathog, 2016 Stress granules (SGs) are membrane-less dynamic structures consisting of mRNA and protein aggregates that form rapidly in response to a wide range of environmental cellular stresses and viral infections. They act as storage sites for translationally silenced mRNAs under stress conditions.
Nikolic J +4 more
europepmc +8 more sources
Insights from the Infection Cycle of VSV-ΔG-Spike Virus [PDF]
Viruses, 2022 Fundamental key processes in viral infection cycles generally occur in distinct cellular sites where both viral and host factors accumulate and interact. These sites are usually termed viral replication organelles, or viral factories (VF). The generation
Elad Milrot +7 more
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