Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles
mBio, 2021 The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee +8 more
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Phase separation and viral factories: unveiling the physical processes supporting RNA packaging in dsRNA viruses. [PDF]
Biochem Soc TransUnderstanding of the physicochemical properties and functions of biomolecular condensates has rapidly advanced over the past decade. More recently, many RNA viruses have been shown to form cytoplasmic replication factories, or viroplasms, via phase ...
Haller CJ +3 more
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Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverse <i>Nucleocytoviricota</i> phylum. [PDF]
Proc Natl Acad Sci U S AInternational audienceDespite sharing fewer than 10 core genes, the hyperdiverse Nucleocytoviricota phylum (ranging from poxviruses to giant viruses) universally assembles viral factories (VFs) resembling biomolecular condensates.
Rigou S +16 more
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Regulation of host translational machinery by African swine fever virus. [PDF]
PLoS Pathogens, 2009 African swine fever virus (ASFV), like other complex DNA viruses, deploys a variety of strategies to evade the host's defence systems, such as inflammatory and immune responses and cell death.
Alfredo Castelló +6 more
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Unpicking the Secrets of African Swine Fever Viral Replication Sites
Viruses, 2021 African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral ...
Sophie-Marie Aicher +3 more
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Viruses, 2023 A wide variety of viruses replicate in liquid-like viral factories. Non-segmented negative stranded RNA viruses share a nucleoprotein (N) and a phosphoprotein (P) that together emerge as the main drivers of liquid–liquid phase separation. The respiratory
Araceli Visentin +6 more
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Non-viral gene delivery in skeletal muscle: a protein factory [PDF]
Gene Therapy, 2003 Ever since the publication of the first reports in 1990 using skeletal muscle as a direct target for expressing foreign transgenes, an avalanche of papers has identified a variety of proteins that can be synthesized and correctly processed by skeletal muscle.
Lu, Q, Bou-Gharios, G, Partridge, T
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The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function. [PDF]
J Virol, 2012 Mammalian orthoreoviruses replicate and assemble in the cytosol of infected cells. A viral nonstructural protein, μNS, forms large inclusion-like structures called viral factories (VFs) in which assembling viral particles can be identified.
Kaufer S, Coffey CM, Parker JS.
europepmc +2 more sources
Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives
Viruses, 2021 Viruses are highly dependent on the host they infect. Their dependence triggers processes of virus–host co-adaptation, enabling viruses to explore host resources whilst escaping immunity.
Temitope Akhigbe Etibor +2 more
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Architecture of viral replication factories
Oncotarget, 2015 Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus ...
Yongliang, Zhang +2 more
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