Results 31 to 40 of about 1,732,794 (242)
Acta Pharmaceutica Sinica B, 2023 Positive-sense RNA viruses modify intracellular calcium stores, endoplasmic reticulum and Golgi apparatus (Golgi) to generate membranous replication organelles known as viral factories.
Kan Xing Wu +11 more
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Journal of Virology, 2022 Molecular mechanisms that control stabilization of ARV proteins and the intermolecular interactions among inclusion components remain largely unknown. Here, we show that the ARV p17 is an Hsp90 client protein.
Wei-Ru Huang +5 more
semanticscholar +1 more source
Regulation of host translational machinery by African swine fever virus. [PDF]
PLoS Pathogens, 2009 African swine fever virus (ASFV), like other complex DNA viruses, deploys a variety of strategies to evade the host's defence systems, such as inflammatory and immune responses and cell death.
Alfredo Castelló +6 more
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Unpicking the Secrets of African Swine Fever Viral Replication Sites
Viruses, 2021 African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral ...
Sophie-Marie Aicher +3 more
doaj +1 more source
Viruses, 2023 A wide variety of viruses replicate in liquid-like viral factories. Non-segmented negative stranded RNA viruses share a nucleoprotein (N) and a phosphoprotein (P) that together emerge as the main drivers of liquid–liquid phase separation. The respiratory
Araceli Visentin +6 more
doaj +1 more source
Insights from the Infection Cycle of VSV-ΔG-Spike Virus
Viruses, 2022 Fundamental key processes in viral infection cycles generally occur in distinct cellular sites where both viral and host factors accumulate and interact. These sites are usually termed viral replication organelles, or viral factories (VF). The generation
Elad Milrot +7 more
doaj +1 more source
Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives
Viruses, 2021 Viruses are highly dependent on the host they infect. Their dependence triggers processes of virus–host co-adaptation, enabling viruses to explore host resources whilst escaping immunity.
Temitope Akhigbe Etibor +2 more
doaj +1 more source
Non-viral gene delivery in skeletal muscle: a protein factory [PDF]
Gene Therapy, 2003 Ever since the publication of the first reports in 1990 using skeletal muscle as a direct target for expressing foreign transgenes, an avalanche of papers has identified a variety of proteins that can be synthesized and correctly processed by skeletal muscle.
Lu, Q, Bou-Gharios, G, Partridge, T
openaire +3 more sources
Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy. [PDF]
Journal of Visualized Experiments, 2018 It is well known that spatial and temporal regulation of genes is an integral part of governing proper gene expression. Consequently, it is invaluable to understand where and when transcription is taking place within nuclear space and to visualize the relationship between episomes infected within the same cell's nucleus.
C. Chen, Frank Y. S. Chuang, Y. Izumiya
semanticscholar +5 more sources
Architecture of viral replication factories
Oncotarget, 2015 Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus ...
Yongliang, Zhang +2 more
openaire +2 more sources