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Nucleocytoviricota Viral Factories Are Transient Organelles Made by Phase Separation [PDF]
Phase separation is a common mechanism utilized by viruses to achieve replication, host manipulation and virion morphogenesis. The newly defined phylum _Nucleocytoviricota_ encompass ubiquitous and diverse viruses including _Poxviridae,_ the climate-modulating _Emiliania huxleyi_ virus and the previously termed Nucleocytoplasmic large DNA viruses ...
Sofia Rigou +13 more
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Unravelling the structure of viral replication complexes at super-resolution [PDF]
Frontiers in Plant Science, 2013 During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components. These structures were first described over a century ago and originally termed ‘X bodies’, as their function was not immediately ...
Olga eLinnik +4 more
doaj +3 more sources
Analysis of HDAC6 and BAG3-Aggresome Pathways in African Swine Fever Viral Factory Formation [PDF]
Viruses, 2015 African swine fever virus (ASFV) is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates and severe economic losses in pigs worldwide.
Raquel Muñoz-Moreno +3 more
doaj +4 more sources
Structure of orthoreovirus RNA chaperone σNS, a component of viral replication factories
Nature Communications, 2023 The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication compartments that support viral genome replication and capsid assembly. Despite its functional importance, a mechanistic understanding of σNS is lacking.
Boyang Zhao +9 more
doaj +6 more sources
Molecular studies of Piscine orthoreovirus : viral factories, kinetics and vaccination [PDF]
, 2018 Piscine orthoreovirus (PRV) is ubiquitous in farmed Atlantic salmon (Salmo salar) and the cause of heart and skeletal muscle inflammation (HSMI). PRV is an orthoreovirus in the family Reoviridae and shows several similarities to the Mammalian orthoreovirus (MRV). Reovirus non-structural proteins are involved in the establishment of viral factories, and
Haatveit, Hanne
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Characterization of a Replicating Mammalian Orthoreovirus with Tetracysteine-Tagged μNS for Live-Cell Visualization of Viral Factories [PDF]
Journal of Virology, 2017 Luke D Bussiere +2 more
exaly +2 more sources
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. [PDF]
J Biol Chem, 2016 Animal-derived RNA viruses frequently generate viral factories in infected cells. However, the details of how RNA viruses build such intracellular structures are poorly understood. In this study, we examined the structure and formation of the viral factories, called viral speckle of transcripts (vSPOTs), that are produced in the nuclei of host cells by
Hirai Y +5 more
europepmc +4 more sources
The Endocytic Recycling Compartment Serves as a Viral Factory for Hepatitis E Virus [PDF]
Cellular and Molecular Life Sciences, 2021 Abstract Background & Aims Although Hepatitis E virus (HEV) is the major leading cause of enterically transmitted viral hepatitis worldwide, many gaps remain in the understanding of the HEV lifecycle. Notably, viral factories induced by HEV have not been documented yet and it is currently unknown
Cyrine Bentaleb +19 more
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Microbiology Spectrum, 2023 In addition to the 3′-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5′-poly(A) leader that confers a translational advantage in virally infected cells.
Pragyesh Dhungel +2 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2023 Positive-sense RNA viruses modify intracellular calcium stores, endoplasmic reticulum and Golgi apparatus (Golgi) to generate membranous replication organelles known as viral factories.
Kan Xing Wu +11 more
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