Results 41 to 50 of about 1,732,794 (242)

The ubiquitin-proteasome system is required for African swine fever replication. [PDF]

PLoS ONE, 2017
Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil, Inmaculada Galindo, Diego Martínez-Alonso, Sergio Viedma, Covadonga Alonso   +4 more
doaj   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Virus-Mediated Compartmentalization of the Host Translational Machinery

mBio, 2014
Viruses require the host translational apparatus to synthesize viral proteins. Host stress response mechanisms that suppress translation, therefore, represent a significant obstacle that viruses must overcome.
Emily A. Desmet, Lynne J. Anguish, John S. L. Parker   +2 more
doaj   +1 more source

The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection

Viruses, 2015
Replication of the poliovirus genome is localized to cytoplasmic replication factories that are fashioned out of a mixture of viral proteins, scavenged cellular components, and new components that are synthesized within the cell due to viral manipulation/
Evan D. Rossignol, Jie E. Yang, Esther Bullitt   +2 more
doaj   +1 more source

Reovirus uses temporospatial compartmentalization to orchestrate core versus outercapsid assembly.

PLoS Pathogens, 2022
Reoviridae virus family members, such as mammalian orthoreovirus (reovirus), encounter a unique challenge during replication. To hide the dsRNA from host recognition, the genome remains encapsidated in transcriptionally active proteinaceous core capsids ...
Justine Kniert, Theodore Dos Santos, Heather E Eaton, Woo Jung Cho, Greg Plummer, Maya Shmulevitz   +5 more
doaj   +1 more source

Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories

bioRxiv, 2023
The reovirus σNS RNA-binding protein is required for formation of intracellular compartments during viral infection that support viral genome replication and capsid assembly.
Boyang Zhao, Li-Ya Hu, Soni Kaundal, Neetu Neetu, Christopher H. Lee, Xayathed Somoulay, B. Sankaran, G. Taylor, T. Dermody, B. V. Venkataram Prasad   +9 more
semanticscholar   +1 more source

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories [PDF]

, 2010
Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only similar to 10% of licensed origins are normally used in S phase, with the others remaining dormant.
Blow, J. Julian; id_orcid, Ge, Xin Quan, J. Julian Blow, Xin Quan Ge, Blow, J. Julian   +4 more
core   +1 more source

Pengaruh Viral Marketing Terhadap Minat Beli Konsumen Richeese Factory

Jurnal Manajemen dan Bisnis (JMB), 2021
Di era digital saat ini teknik viral marketing adalah pilihan yang tepat dalam berbisnis online maupun offline, apalagi di dukung dengan metode pemasaran yang sangat beragam sehingga dapat menghasilkan keuntungan yang sangat besar. Penelitian ini bertujuan untuk mengetahui pengaruh : (1) viral marketing terhadap minat beli konsumen, (2) Kepercayaan ...
Anggun Fadila, Alika Fadiya Haya, Hero Desyantama   +2 more
openaire   +1 more source

A Spotlight on Viruses—Application of Click Chemistry to Visualize Virus-Cell Interactions

Molecules, 2019
The replication of a virus within its host cell involves numerous interactions between viral and cellular factors, which have to be tightly controlled in space and time.
Thorsten G. Müller, Volkan Sakin, Barbara Müller   +2 more
doaj   +1 more source

Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection

Viruses, 2020
Zika virus (ZIKV; Flaviviridae) is a mosquito-borne flavivirus shown to cause fetal abnormalities collectively known as congenital Zika syndrome and Guillain-Barré syndrome in recent outbreaks.
Jamie Royle, Carolina Ramírez-Santana, Snezhana Akpunarlieva, Claire L. Donald, Rommel J. Gestuveo, Juan-Manuel Anaya, Andres Merits, Richard Burchmore, Alain Kohl, Margus Varjak   +9 more
doaj   +1 more source