Results 51 to 60 of about 1,732,794 (242)

Ribosomal control in RNA virus-infected cells

Frontiers in Microbiology, 2022
Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release.
Xiao Wang, Jie Zhu, Da Zhang, Guangqing Liu   +3 more
doaj   +1 more source

Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverse Nucleocytoviricota phylum

Proceedings of the National Academy of Sciences of the United States of America
Significance Viral factories (VFs) are organelle-like compartments that are conserved across the Nucleocytoviricota phylum despite extensive genomic diversity. How such phenotypic conservation is maintained remains unknown.
Sofia Rigou, Alain Schmitt, Anaísa B. Moreno, A. Lartigue, Lucile Danner, Lotte Mayer, Claire Giry, Feres Trabelsi, L. Belmudes, Natalia Olivero-Deibe, Hugo Le Guenno, Y. Couté, Mabel Berois, M. Legendre, Sandra Jeudy, Chantal Abergel, Hugo Bisio   +16 more
semanticscholar   +1 more source

Live-Cell Imaging of Vaccinia Virus Recombination. [PDF]

PLoS Pathogens, 2016
Recombination between co-infecting poxviruses provides an important mechanism for generating the genetic diversity that underpins evolution. However, poxviruses replicate in membrane-bound cytoplasmic structures known as factories or virosomes. These are
Patrick Paszkowski, Ryan S Noyce, David H Evans   +2 more
doaj   +1 more source

5-Bromo-2'-deoxyuridine inhibits African swine fever virus (ASFV) replication via interfering viral DNA replication and suppressing the formation of viral factories.

Virology
African swine fever (ASF), caused by ASF virus (ASFV), represents one of the most economically important viral infectious diseases in swine industry worldwide. So far there is no vaccine or antiviral drug for controlling ASF pandemics.
Feixiang Long, Weixin Ou, Zexing Liu, Guan-Ming Su, Qisheng Lin, Guo-Ming Su, Jinyi Liu, Jian-Xin Chen, Ding Luo   +8 more
semanticscholar   +1 more source

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories

Science Advances
Many viral proteins form biomolecular condensates via liquid-liquid phase separation (LLPS) to support viral replication and evade host antiviral responses, and thus, they are potential targets for designing antivirals.
Soni Kaundal, R. Anish, B. V. Ayyar, S. Shanker, Gundeep Kaur, S. Crawford, Jeroen Pollet, F. Stossi, M. K. Estes, B. V. Venkataram Prasad   +9 more
semanticscholar   +2 more sources

Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS.

PLoS ONE, 2017
Mammalian orthoreovirus protein μ2 is a component of the viral core particle. Its activities include RNA binding and hydrolysis of the γ-phosphate from NTPs and RNA 5´-termini, suggesting roles as a cofactor for the viral RNA-dependent RNA polymerase, λ3,
Catherine Eichwald, Jonghwa Kim, Max L Nibert   +2 more
doaj   +1 more source

Replication Compartments—The Great Survival Strategy for Epstein–Barr Virus Lytic Replication

Microorganisms, 2022
During Epstein–Barr virus (EBV) lytic replication, viral DNA synthesis is carried out in viral replication factories called replication compartments (RCs), which are located at discrete sites in the nucleus.
Atsuko Sugimoto
doaj   +1 more source

Phase separation and viral factories: unveiling the physical processes supporting RNA packaging in dsRNA viruses

Biochemical Society Transactions
Understanding of the physicochemical properties and functions of biomolecular condensates has rapidly advanced over the past decade. More recently, many RNA viruses have been shown to form cytoplasmic replication factories, or viroplasms, via phase ...
Cyril Haller, Julia Acker, A. E. Arguello, A. Borodavka   +3 more
semanticscholar   +1 more source

Purification of HCV-remodeled and Control ER Membranes

Bio-Protocol, 2014
As for all positive strand RNA viruses, hepatitis C virus (HCV) RNA replication is tightly associated with rearranged host cell membranes, termed viral replication factories.
David Paul, Ralf Bartenschlager
doaj   +1 more source

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

eLife, 2022
Despite an unprecedented global research effort on SARS-CoV-2, early replication events remain poorly understood. Given the clinical importance of emergent viral variants with increased transmission, there is an urgent need to understand the early stages
Jeffrey Y Lee, Peter AC Wing, Dalia S Gala, Marko Noerenberg, Aino I Järvelin, Joshua Titlow, Xiaodong Zhuang, Natasha Palmalux, Louisa Iselin, Mary Kay Thompson, Richard M Parton, Maria Prange-Barczynska, Alan Wainman, Francisco J Salguero, Tammie Bishop, Daniel Agranoff, William James, Alfredo Castello, Jane A McKeating, Ilan Davis   +19 more
doaj   +1 more source