Proviral NUP153 binding to viral proteins and RNA regulates structural–nonstructural protein ratios in orthoflavivirus infection [PDF]
Nature CommunicationsOrthoflaviviruses are RNA viruses that cause serious diseases in humans, with currently no antivirals available. Targeting host factors is emerging as an attractive antiviral approach.
Marie B. A. Peters +10 more
doaj +5 more sources
The Expression and Function of the Small Nonstructural Proteins of Adeno-Associated Viruses (AAVs)
VirusesAdeno-associated viruses (AAVs) are small, non-enveloped viruses that package a single-stranded (ss)DNA genome of 4.7 kilobases (kb) within their T = 1 icosahedral capsid.
Cagla Aksu Kuz +2 more
doaj +2 more sources
Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay [PDF]
Journal of VirologyAlphaviruses can cause polyarthralgia and encephalitis and pose an escalating global health threat to humans and animals. They are transmitted to vertebrates mainly by infected mosquitoes, leading to host alternation that drives an evolutionary arms race
Ana Alice Pimenta-Pereira +2 more
doaj +2 more sources
Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering [PDF]
Journal of VirologyAlphavirus-derived vector systems have been used for heterologous gene expression for nearly four decades, providing foundational insights into RNA virus replication, host interactions, and genome engineering.
Dan T. Boghici +3 more
doaj +2 more sources
Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection [PDF]
Viruses, 2021 Dengue virus (DENV) infection causes a spectrum of dengue diseases that have unclear underlying mechanisms. Nonstructural protein 1 (NS1) is a multifunctional protein of DENV that is involved in DENV infection and dengue pathogenesis. This study investigated the potential post-translational modification of DENV NS1 by phosphorylation following DENV ...
Thanyaporn Dechtawewat +15 more
openaire +3 more sources
Rotavirus Nonstructural Protein NSP3 Is Not Required for Viral Protein Synthesis [PDF]
Journal of Virology, 2006 ABSTRACT Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the 5′ end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3′ end, is recognized by the ...
Hilda, Montero +2 more
openaire +2 more sources
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis [PDF]
Cell Host & Microbe, 2019 Murine norovirus (MNoV) infects a low percentage of enteric tuft cells and can persist in these cells for months following acute infection. Both tuft-cell tropism and resistance to interferon-λ (IFN-λ)-mediated clearance during persistent infection requires the viral nonstructural protein 1/2 (NS1/2).
Sanghyun, Lee +13 more
openaire +2 more sources
A Viral Nonstructural Protein Regulates Bluetongue Virus Trafficking and Release [PDF]
Journal of Virology, 2009 ABSTRACT Bluetongue virus (BTV), a nonenveloped insect-borne virus, is released from infected cells by multiple pathways. Unlike other nonenveloped viruses, in addition to cell lysis the newly synthesized virus particles also appear to use a unique “budding” process.
Cristina C P, Celma, Polly, Roy
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Complementation of a Deletion in the Rubella Virus P150 Nonstructural Protein by the Viral Capsid Protein [PDF]
Journal of Virology, 2003 ABSTRACT Rubella virus (RUB) replicons with an in-frame deletion of 507 nucleotides between two Not I sites in the P150 nonstructural protein (Δ Not I) do not replicate (as detected by expression of a reporter gene encoded by the replicon) but can be amplified by wild-type helper ...
Wen-Pin, Tzeng, Teryl K, Frey
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Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K. +4 more
core +3 more sources