Results 11 to 20 of about 35,514 (220)

Porcine reproductive and respiratory syndrome virus antagonizes the host restriction factor SHFL to sustain viral programmed ribosomal frameshifting and replication [PDF]

Journal of Virology
The global pandemic of porcine reproductive and respiratory syndrome virus (PRRSV) and its continuous evolution pose a sustained threat to the swine industry, underscoring the urgent need for a broad-spectrum antiviral strategy.
Kefan Bu, Jing Shi, Jingjing Ding, Tao Xu, Qingyu Li, Chenxi Li, Yanhua Li   +6 more
doaj   +2 more sources

Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection [PDF]

Viruses, 2021
Dengue virus (DENV) infection causes a spectrum of dengue diseases that have unclear underlying mechanisms. Nonstructural protein 1 (NS1) is a multifunctional protein of DENV that is involved in DENV infection and dengue pathogenesis. This study investigated the potential post-translational modification of DENV NS1 by phosphorylation following DENV ...
Thanyaporn Dechtawewat, Sittiruk Roytrakul, Yodying Yingchutrakul, Sawanya Charoenlappanit, Bunpote Siridechadilok, Thawornchai Limjindaporn, Arunothai Mangkang, Tanapan Prommool, Chunya Puttikhunt, Pucharee Songprakhon, Kessiri Kongmanas, Nuttapong Kaewjew, Panisadee Avirutnan, Pa-thai Yenchitsomanus, Prida Malasit, Sansanee Noisakran   +15 more
openaire   +3 more sources

Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins [PDF]

PLoS Pathogens, 2015
Andrew Kohlway, Michael S Diamond, Brett D Lindenbach   +2 more
exaly   +2 more sources

Rotavirus Nonstructural Protein NSP3 Is Not Required for Viral Protein Synthesis [PDF]

Journal of Virology, 2006
ABSTRACT Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the 5′ end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3′ end, is recognized by the ...
Hilda, Montero, Carlos F, Arias, Susana, Lopez   +2 more
openaire   +2 more sources

Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)

Вопросы вирусологии, 2023
Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva, A. V. Gladysheva, V. A. Ternovoi, V. B. Loktev   +3 more
doaj   +1 more source

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis [PDF]

Cell Host & Microbe, 2019
Murine norovirus (MNoV) infects a low percentage of enteric tuft cells and can persist in these cells for months following acute infection. Both tuft-cell tropism and resistance to interferon-λ (IFN-λ)-mediated clearance during persistent infection requires the viral nonstructural protein 1/2 (NS1/2).
Sanghyun, Lee, Hejun, Liu, Craig B, Wilen, Zoi E, Sychev, Chandni, Desai, Barry L, Hykes, Robert C, Orchard, Broc T, McCune, Ki-Wook, Kim, Timothy J, Nice, Scott A, Handley, Megan T, Baldridge, Gaya K, Amarasinghe, Herbert W, Virgin   +13 more
openaire   +2 more sources

Flavivirus Capsid Proteins Inhibit the Interferon Response

Viruses, 2022
Zika virus (ZIKV) establishes persistent infections in multiple human tissues, a phenomenon that likely plays a role in its ability to cause congenital birth defects and neurological disease. Multiple nonstructural proteins encoded by ZIKV, in particular
Adriana M. Airo, Alberto Felix-Lopez, Valeria Mancinelli, Danyel Evseev, Joaquin Lopez-Orozco, Kathy Shire, Patrick Paszkowski, Lori Frappier, Katharine E. Magor, Tom C. Hobman   +9 more
doaj   +1 more source

Functional studies of the coronavirus nonstructural proteins

STEMedicine, 2020
Coronaviruses, including SARS-CoV, SARS-CoV-2, and MERS-CoV, have caused contagious and fatal respiratory diseases in humans worldwide. Notably, the coronavirus disease 19 (COVID-19) caused by SARS-CoV-2 spread rapidly in early 2020 and became a global ...
Yanglin Qiu, Kai Xu
doaj   +1 more source

Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation

mBio, 2022
Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals.
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose   +8 more
doaj   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source