Molecular Dynamics Simulations to Decipher the Role of Phosphorylation of SARS-CoV-2 Nonstructural Proteins (nsps) in Viral Replication [PDF]
Viruses, 2022 Protein phosphorylation is a post-translational modification that enables various cellular activities and plays essential roles in protein interactions.
Lamya Alomair +8 more
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Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development [PDF]
Viruses, 2018 Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available.
Farhana Abu Bakar, Lisa F. P. Ng
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Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation [PDF]
Viruses, 2022 Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans.
Anastasia Latanova +2 more
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Nonstructural proteins 2B and 4A of Tembusu virus induce complete autophagy to promote viral multiplication in vitro [PDF]
Veterinary Research, 2023 Tembusu virus (TMUV) is an emerging flavivirus that has broken out in different regions of China. TMUV infection has been reported to induce autophagy in duck embryo fibroblast cells.
Wangyang Tan +19 more
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Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins
Membranes, 2022 Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
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The Expression and Function of the Small Nonstructural Proteins of Adeno-Associated Viruses (AAVs) [PDF]
VirusesAdeno-associated viruses (AAVs) are small, non-enveloped viruses that package a single-stranded (ss)DNA genome of 4.7 kilobases (kb) within their T = 1 icosahedral capsid.
Cagla Aksu Kuz +2 more
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HSP27 Interacts with Nonstructural Proteins of Porcine Reproductive and Respiratory Syndrome Virus and Promotes Viral Replication [PDF]
Pathogens, 2023 Heat shock protein 27 (HSP27) is a multifunctional protein and belongs to the small HSP family. It has been shown that HSP27 is involved in viral replication as a cellular chaperone, but the function of HSP27 during porcine reproductive and respiratory ...
Chunhui Song +4 more
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Chikungunya virus: Molecular epidemiology of nonstructural proteins in Pakistan. [PDF]
PLoS ONE, 2021 Chikungunya virus (CHIKV) is considered a public health problem due to its rapid spread and high morbidity. In 2016-2017 an outbreak of CHIKV was occurred in Pakistan but the data regarding the genomic diversity of CHIKV was not reported.
Nazish Badar +11 more
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Pathogenicity and virulence of human respiratory syncytial virus: Multifunctional nonstructural proteins NS1 and NS2 [PDF]
VirulenceHuman respiratory syncytial virus (hRSV) is a major cause of lower respiratory tract infections in young children, the elderly, and immunocompromised.
Trudy N. Merritt +2 more
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Unlocking the secrets of Feline calicivirus: advances in structural and nonstructural proteins and its role as a key model for other Caliciviruses [PDF]
Virology JournalFeline calicivirus (FCV) is a highly contagious pathogen responsible for respiratory infections, lingual ulceration, oral ulcers and systemic diseases in cats, posing a significant risk to feline family worldwide.
Sana Asif, Deng Yingkun, Chunchun Meng
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