Results 41 to 50 of about 1,587,098 (210)

Non-Canonical Roles of Dengue Virus Non-Structural Proteins

Viruses, 2017
The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes.
Julianna D. Zeidler, Lorena O. Fernandes-Siqueira, Glauce M. Barbosa, Andrea T. Da Poian   +3 more
doaj   +1 more source

Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein [PDF]

, 2012
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral ...
Krause Kurt L., Luckner, Sylvia R., Krause, Kurt L., Luckner Sylvia R., Lambden, Paul R., Sylvia R Luckner, Kurt L Krause, Clarke, Ian N., Paul R Lambden, Baker, Estelle S., Ian N Clarke, Baker Estelle S., Estelle S Baker, Ward Vernon K., Lambden Paul R., Ward, Vernon K., Clarke Ian N., Vernon K Ward   +17 more
core   +1 more source

Proteomic interactions in the mouse vitreous-retina complex. [PDF]

PLoS ONE, 2013
Human vitreoretinal diseases are due to presumed abnormal mechanical interactions between the vitreous and retina, and translational models are limited. This study determined whether nonstructural proteins and potential retinal biomarkers were expressed ...
Jessica M Skeie, Vinit B Mahajan
doaj   +1 more source

Involvement of a Nonstructural Protein in Poliovirus Capsid Assembly [PDF]

Journal of Virology, 2019
RNA viruses, including poliovirus, evolve rapidly due to the error-prone nature of the polymerase enzymes involved in genome replication. Fixation of advantageous mutations may require the acquisition of complementary mutations which can act in concert to achieve a favorable phenotype.
Adeyemi, OO, Sherry, L, Ward, JC, Pierce, DM, Herod, MR, Rowlands, DJ, Stonehouse, N   +6 more
openaire   +3 more sources

Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense

Biomolecules & Biomedicine, 2021
Coronavirus disease-19 (COVID-19) is an extremely infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has become a major global health concern.
Abualgasim Elgaili Abdalla , Jianping Xie, Kashaf Junaid, Sonia Younas, Tilal Elsaman, Khalid Omer Abdalla Abosalif, Ayman Ali Mohammed Alameen, Mahjoob Osman Mahjoob, Mohammed Yagoub Mohammed Elamir, Hasan Ejaz   +9 more
doaj   +1 more source

MAVS Protein Is Attenuated by Rotavirus Nonstructural Protein 1

PLoS ONE, 2014
Rotavirus is the single, most important agent of infantile gastroenteritis in many animal species, including humans. In developing countries, rotavirus infection attributes approximately 500,000 deaths annually. Like other viruses it establishes an intimate and complex interaction with the host cell to counteract the antiviral responses elicited by the
Satabdi Nandi, Shampa Chanda, Parikshit Bagchi, Mukti Kant Nayak, Rahul Bhowmick, Mamta Chawla-Sarkar   +5 more
openaire   +4 more sources

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source

Nonstructural Protein 5B of Hepatitis C Virus

Molecules and Cells, 2006
Since its identification in 1989, hepatitis C virus has been the subject of extensive research. The biology of the virus and the development of antiviral drugs are closely related. The RNA polymerase activity of nonstructural protein 5B was first demonstrated in 1996.
Jong-Ho, Lee, In Young, Nam, Heejoon, Myung   +2 more
openaire   +2 more sources

Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model [PDF]

, 2014
Investigations into human norovirus infection, replication and pathogenesis, as well as the development of potential antiviral agents, have been restricted by the lack of a cell culture system for human norovirus.
Morgan R. Herod (530748), Rachel J Skilton, Cynthia A. Prince (530749), Morgan R Herod, Clarke, IN, Vernon K. Ward (333594), Skilton, RJ, Herod, Morgan R., Omar Salim, Clarke, Ian N., Ian N Clarke, Rachel J. Skilton (204339), Ian N. Clarke (46223), Ward, Vernon K., Prince, Cynthia A., Vernon K Ward, Lambden, PR, Lambden, Paul R., Ward, VK, Paul R. Lambden (46224), Skilton, Rachel J., Paul R Lambden, Omar Salim (46222), Prince, CA, Cynthia A Prince, Herod, MR, Salim, O, Salim, Omar   +27 more
core   +1 more source

Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins.

PLoS Pathogens, 2022
Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While NS1 is linked to important nuclear processes required for viral replication, much less is known about the role of NS2. Specifically, the function of canine parvovirus (
Salla Mattola, Kari Salokas, Vesa Aho, Elina Mäntylä, Sami Salminen, Satu Hakanen, Einari A Niskanen, Julija Svirskaite, Teemu O Ihalainen, Kari J Airenne, Minna Kaikkonen-Määttä, Colin R Parrish, Markku Varjosalo, Maija Vihinen-Ranta   +13 more
doaj   +1 more source