Results 61 to 70 of about 1,587,098 (210)

Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)

Вопросы вирусологии, 2023
Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva, A. V. Gladysheva, V. A. Ternovoi, V. B. Loktev   +3 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Dengue virus NS4B protein as a target for developing antivirals

Frontiers in Cellular and Infection Microbiology, 2022
Dengue virus is an important pathogen affecting global population while no specific treatment is available against this virus. Effort has been made to develop inhibitors through targeting viral nonstructural proteins such as NS3 and NS5 with enzymatic ...
Qingxin Li, Congbao Kang
doaj   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

mBio, 2017
Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals.
Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena   +7 more
doaj   +1 more source

Network of Interactions between ZIKA Virus Non-Structural Proteins and Human Host Proteins

Cells, 2020
The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an infected mosquito bite or through human-to-human interaction by sexual activity, blood transfusion, breastfeeding, or perinatal exposure.
Volha A. Golubeva, Thales C. Nepomuceno, Giuliana de Gregoriis, Rafael D. Mesquita, Xueli Li, Sweta Dash, Patrícia P. Garcez, Guilherme Suarez-Kurtz, Victoria Izumi, John Koomen, Marcelo A. Carvalho, Alvaro N. A. Monteiro   +11 more
doaj   +1 more source

Prevalence of Reversed Genome Organizations for Viruses in the Family Iflaviridae, Order Picornavirales

Microbiology Spectrum, 2023
Viruses in the order Picornavirales possess a positive-strand RNA genome that encodes structural proteins (SPs) and nonstructural proteins (NSPs). According to the recent report of the International Committee on Taxonomy of Viruses (ICTV), there are 8 ...
Yan Zhang, Zhuang-Xin Ye, Xiao-Xiao Feng, Zhong-Tian Xu, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li   +6 more
doaj   +1 more source

Optimization of moisture content and application rate of hay preservative during high‐moisture alfalfa hay baling in northwestern China

Grassland Research, EarlyView.
Abstract Background Leaf shatter during low‐moisture baling and mold proliferation under high‐moisture conditions pose major challenges in alfalfa hay production. A proprietary propionic acid‐based hay preservative product, LZP, effectively inhibits microbial reproduction in high‐moisture alfalfa bales; however, its optimal moisture thresholds and ...
Zulin Yuan, Fuhou Li, Jing Li, Dongmei Xu, Samaila Usman, Xusheng Guo, Yingwen Yu   +6 more
wiley   +1 more source

Sequence analysis of the small (s) RNA segment of viruses in the genus Orthobunyavirus [PDF]

, 2008
Viruses in the genus Orthobunyavirus (family Bunyaviridae) are classified serologically into 18 serogroups. The viruses have a tripartite genome of negative sense RNA composed of large (L), medium (M) and small (S) segments.
Mohamed, Maizan
core   +2 more sources

Strigolactone signaling: Licensing antiviral RNA interference in rice

New Plant Protection, EarlyView.
Rice grassy stunt virus (RGSV) suppresses strigolactone‐mediated antiviral RNAi through P3‐D14 interaction. Structure‐guided D14D102N editing disrupts P3 binding while maintaining SL signaling, sustaining antiviral defense and providing strong resistance without compromising plant growth or yield.
Kaibo Gu, Yanjun Li
wiley   +1 more source