Results 71 to 80 of about 1,587,098 (210)

The transient nature of bunyamwera orthobunyavirus NSs protein expression : effects of increased stability of NSs protein on virus replication [PDF]

, 2013
The NSs proteins of bunyaviruses are the viral interferon antagonists, counteracting the host's antiviral response to infection. During high-multiplicity infection of cultured mammalian cells with Bunyamwera orthobunyavirus (BUNV), NSs is rapidly ...
Fragkoudis, R., Rennos Fragkoudis, Richard M Elliott, Ingeborg van Knippenberg, van Knippenberg, I., van Knippenberg, Ingeborg, Fragkoudis, Rennos, Elliott, Richard M., Elliott, R.M.   +8 more
core   +1 more source

Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions

Viruses, 2013
Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus ...
Alain Kohl, Anne-Lie Blomström, Isabelle Dietrich, Saleh Eifan, Esther Schnettler   +4 more
doaj   +1 more source

Experimental Dengue Virus Type 4 Infection Increases the Expression of MicroRNAs-15/16, Triggering a Caspase-Induced Apoptosis Pathway

Current Issues in Molecular Biology, 2023
The World Health Organization has estimated the annual occurrence of approximately 392 million dengue virus (DENV) infections in more than 100 countries where the virus is endemic, which represents a serious threat to humanity.
Samir Mansour Moraes Casseb, Karla Fabiane Lopes de Melo, Carlos Alberto Marques de Carvalho, Carolina Ramos dos Santos, Edna Cristina Santos Franco, Pedro Fernando da Costa Vasconcelos   +5 more
doaj   +1 more source

Evolution of the SARS‐CoV‐2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to evolve and diversify, leading to the emergence of immune‐evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because
David Ferreiro, Miguel Arenas
wiley   +1 more source

Proteolytic processing of a human astrovirus nonstructural protein

Journal of General Virology, 2002
To analyse the activity of the putative 3C-like serine protease encoded in open reading frame (ORF)-1a of human astrovirus serotype 1 (HAstV-1), ORF-1a was transcribed and translated in vitro. Translation products, identified by immunoprecipitation with specific antibodies against recombinant C-terminal ORF-1a fragments, include the full-length 101 kDa
David, Kiang, Suzanne M, Matsui
openaire   +2 more sources

The substitutions of nonstructural proteins during the five waves of SARS-CoV2 pandemic in Iran.

, 2022
The substitutions of nonstructural proteins during the five waves of SARS-CoV2 pandemic in Iran.
Jila Yavarian (12488177), Ahmad Nejati (11853467), Mohammad Mehdi Gouya (9588253), Nazanin Zahra Shafiei Jandaghi (12488180), Adel Abedi (12488186), Kaveh Sadeghi (12488183), Talat Mokhtari-Azad (306056), Vahid Salimi (475780), Ali Sharifi Zarchi (11726382)   +8 more
core   +1 more source

Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories

Journal of Virology
Early in infection, mammalian orthoreoviruses (reoviruses) build neo-organelles called viral factories (VFs). These structures incorporate fragments of endoplasmic reticulum (ER) and serve as sites of viral genome replication and particle assembly.
Raquel Tenorio, Gwen M. Taylor, Ana Cayuela, C. O. S. Sorzano, Isabel Fernández de Castro, Sara Y. Fernández-Sánchez, Alexa N. Roth, Xayathed Somoulay, Gavin S. Treadaway, Terence S. Dermody, Cristina Risco   +10 more
doaj   +1 more source

Coronaviruses fusion with the membrane and entry to the host cell

Annals of Agricultural and Environmental Medicine, 2020
Coronaviruses (CoVs) are positive-strand RNA viruses with the largest genome among all RNA viruses. They are able to infect many host, such as mammals or birds.
Ewelina Wędrowska, Tomasz Wandtke, Tomasz Senderek, Elżbieta Piskorska, Piotr Kopiński   +4 more
doaj   +1 more source

Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localized in the Polymerase (3D ^pol )-Encoding Region

mSphere, 2021
Some RNA structures formed by the genomes of RNA viruses are critical for viral replication. Our study shows that of 46 conserved RNA structures located within the regions of the foot-and-mouth disease virus (FMDV) genome that encode the nonstructural ...
Lidia Lasecka-Dykes, Fiona Tulloch, Peter Simmonds, Garry A. Luke, Paolo Ribeca, Sarah Gold, Nick J. Knowles, Caroline F. Wright, Jemma Wadsworth, Mehreen Azhar, Donald P. King, Tobias J. Tuthill, Terry Jackson, Martin D. Ryan   +13 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source