Results 31 to 40 of about 1,587,098 (210)

Structural and Nonstructural Proteins of an Arbovirus [PDF]

Journal of Virology, 1968
Purified Semliki Forest virus (SFV) contains three structural proteins while its core (nucleocapsid) contains two of these proteins. To identify all of the proteins synthesized under virus direction, cells were infected with SFV in the presence of actinomycin D and guanidine.
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A Protein Linkage Map of the P2 Nonstructural Proteins of Poliovirus [PDF]

Journal of Virology, 1998
ABSTRACTThe yeast two-hybrid system was used to catalog all detectable interactions among the P2 nonstructural cleavage products of poliovirus type 1 (Mahoney). Evidence has been obtained for specific associations among 2Apro, 2BC, 2C, and 2B. Specifically, 2Aprocan interact with itself and 2BC and its cleavage products (2B and 2C) interact in all ...
A, Cuconati, W, Xiang, F, Lahser, T, Pfister, E, Wimmer   +4 more
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Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
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Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon [PDF]

, 2002
Production of alpha/beta interferons (IFN-α/β) in response to viral infection is one of the main defense mechanisms of the innate immune system. Many viruses therefore encode factors that subvert the IFN system to enhance their virulence.
Richard E. Randall, Randall, Richard E, Friedemann Weber, Fazakerley, John K., Nina Kessler, Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, Elliott, Richard M, Randall, R.E., Kessler, N, Elliott, R.M., Streitenfeld, H., Richard M. Elliott, Kessler, N., Anne Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J.K., Kessler, Nina, Hein Streitenfeld, Bridgen, A, Elliott, Richard Michael, Fazakerley, JK, John K. Fazakerley, Bridgen, Anne, Randall, Richard Edward   +29 more
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Differentiation of Foot-and-Mouth Disease-Infected pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA [PDF]

, 2011
The presence of serum antibodies for nonstructural proteins of the foot-and-mouth disease virus (FMDV) can differentiate FMDV-infected animals from vaccinated animals.
Ming-Hwa JONG, Dekker, A., Wen-Bin CHUNG, Lin, Y.L., Fan LEE, Yeou-Liang LIN, Chen, T.H., Ming-Chang LEE, Chu-Hsiang PAN, Hsiang-Jung TSAI, Aldo DEKKER, Lee, M.C., Tsai, H.J., Tsu-Han CHEN, Chin-Cheng HUANG, Chung, W.B., Pan, C.H., Jong, M.H., Huang, C.C., Lee, F.   +19 more
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Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulation for the Discovery of Novel SARS-CoV-2 NSP3 Mac1 Domain Inhibitors

Viruses, 2023
Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs).
Behnaz Yazdani, Hajar Sirous, Simone Brogi, Vincenzo Calderone   +3 more
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Analysis of coevolution in nonstructural proteins of chikungunya virus [PDF]

Virology Journal, 2016
RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-species.
Jain, Jaspreet, Mathur, Kalika, Shrinet, Jatin, Bhatnagar, Raj K., Sunil, Sujatha   +4 more
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Processing of Nonstructural Protein 1a of Human Astrovirus [PDF]

Journal of Virology, 2002
ABSTRACT Astrovirus contains three open reading frames (ORF) on its genomic RNA, ORF1a, ORF1b, and ORF2. ORF1a encodes a 920-amino-acid (aa) nonstructural protein, nsP1a, which displays a 3C-like serine protease motif. Little is known about the processing of nsP1a or whether the protease it contains is active and involved in autocatalytic ...
Ute, Geigenmüller, Teri, Chew, Nancy, Ginzton, Suzanne M, Matsui   +3 more
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SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13

Frontiers in Microbiology, 2022
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2 proteins is important for drug design
Bo Zhang, Yan Xie, Zhaoling Lan, Dayu Li, Junjie Tian, Qintao Zhang, Hongji Tian, Jiali Yang, Xinnan Zhou, Shuyi Qiu, Keyu Lu, Yang Liu, Yang Liu   +12 more
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Analysis of Rotavirus Nonstructural Protein NSP5 Phosphorylation [PDF]

Journal of Virology, 1998
ABSTRACT The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures.
J, Blackhall, M, Muñoz, A, Fuentes, G, Magnusson   +3 more
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