Hyperphosphorylation of the Rotavirus NSP5 Protein Is Independent of Serine 67 or NSP2, and the Intrinsic Insolubility of NSP5 Is Regulated by Cellular Phosphatases [PDF]
Journal of Virology, 2006 ABSTRACT The NSP5 protein is required for viroplasm formation during rotavirus infection and is hyperphosphorylated into 32- to 35-kDa isoforms. Earlier studies reported that NSP5 is not hyperphosphorylated without NSP2 coexpression or deleting the NSP5 N terminus and that serine 67 is essential for NSP5 hyperphosphorylation.
Adrish, Sen +2 more
openaire +2 more sources
Analysis of genetic diversity and molecular evolution of human group B rotaviruses based on whole genome segments [PDF]
, 2010 Group B rotavirus (GBR) is a rare enteric pathogen that causes severe diarrhoea, primarily in adults. Nearly full-length sequences of all 11 RNA segments were determined for human GBRs detected recently in India (IDH-084 in 2007, IC-008 in 2008 ...
Ahmed +37 more
core +1 more source
Emerging Microbes and Infections, 2021 The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication.
Mehdi Moustaqil +12 more
doaj +1 more source
Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus [PDF]
, 2015 Porcine reproductive and respiratory syndrome virus (PRRSV) is currently one of the most important viruses affecting the swine industry worldwide. Despite the large number of papers published each year, the participation of non-structural proteins (nsps)
Burgara Estrella, Alexel +3 more
core +4 more sources
Fusion of Tags Induces Spurious Phosphorylation of Rotavirus NSP5 [PDF]
Journal of Virology, 2006 Several findings in the paper by Sen et al. entitled “Hyperphosphorylation of the rotavirus NSP5 protein is independent of serine 67 or NSP2, and the intrinsic insolubility of NSP5 is regulated by cellular phosphatases” (5) seem to contradict previous published findings from our laboratory.
Michela Campagna, Oscar R. Burrone
openaire +1 more source
Cleavage of the selective autophagy receptor NBR1 by the PDCoV main protease NSP5 impairs autophagic degradation of the viral envelope protein [PDF]
AutophagyAnan Jongkaewwattana
exaly +2 more sources
Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses [PDF]
, 2016 Within the last 15 years, two related coronaviruses (Severe Acute Respiratory Syndrome [SARS]-CoV and Middle East Respiratory Syndrome [MERS]-CoV) expanded their host range to include humans, with increased virulence in their new host. Coronaviruses were
Rahaman, Jordon +1 more
core +1 more source
Viroplasms: Assembly and Functions of Rotavirus Replication Factories
Viruses, 2021 Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formation ...
Guido Papa +2 more
doaj +1 more source
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]
, 2020 An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong +15 more
core
Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments [PDF]
, 2017 Segmented RNA viruses are ubiquitous pathogens, which include influenza viruses and rotaviruses. A major challenge in understanding their assembly is the combinatorial problem of a non-random selection of a full genomic set of distinct RNAs. This process
Borodavka, A +3 more
core +5 more sources