Results 51 to 60 of about 5,845 (181)
Interaction of rotavirus nonstructural protein NSP5 with the viral replication complex [PDF]
, 2008 Rotavirus morphogenesis starts in intracellular inclusion bodies called viroplasms, where synthesis of the11 dsRNA genome segments and their packaging in new viral particles take place. RNA replication is mediated by several viral proteins, of which VP1, the RNA-dependent RNA polymerase, and VP2, the core scaffolding protein, were shown to be ...
Arnoldi, Francesca
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Hyperphosphorylation of the Rotavirus NSP5 Protein Is Independent of Serine 67, NSP2, or the Intrinsic Insolubility of NSP5 and Is Regulated by Cellular Phosphatases [PDF]
Journal of Virology, 2006 The NSP5 protein is required for viroplasm formation during rotavirus infection and is hyperphosphorylated into 32- to 35-kDa isoforms. Earlier studies reported that NSP5 is not hyperphosphorylated without NSP2 coexpression or deleting the NSP5 N terminus and that serine 67 is essential for NSP5 hyperphosphorylation.
Adrish Sen +2 more
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Molecular Biomedicine, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) global pandemic. Omicron, a new variant of SARS-CoV-2, has the characteristics of strong transmission and pathogenicity, short incubation ...
Yabin Zhang +4 more
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mBio, 2022 Coronaviruses (CoVs) are a family of RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of CoVs to illustrate the reciprocal regulation between
Fushan Shi +12 more
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Communications Biology, 2023 A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MProWT) from precursor polyproteins. Upon expression, a model precursor of MProWT mediates its own release at its termini rapidly to yield a mature ...
Annie Aniana +6 more
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Viruses, 2022 The dysregulation of host signaling pathways plays a critical role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and viral pathogenesis. While a number of viral proteins that can block type I IFN signaling have been identified,
Abhishek Kumar +3 more
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Phosphorylation Generates Different Forms of Rotavirus NSP5
Journal of General Virology, 1996 NSP5 (non-structural protein 5) is one of two proteins encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the virosomes and is found as two polypeptides with molecular masses of 26 and 28 kDa (26K and 28K proteins).
I, Afrikanova +3 more
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Computational and Structural Biotechnology Journal, 2021 There is an urgent need to develop effective treatments for coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Fangfang Yan, Feng Gao
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Serine protein kinase activity associated with rotavirus phosphoprotein NSP5 [PDF]
Journal of Virology, 1997 The rotavirus nonstructural protein NSP5, a product of the smallest genomic RNA segment, is a phosphoprotein containing O-linked N-acetylglucosamine. We investigated the phosphorylation of NSP5 in monkey MA104 cells infected with simian rotavirus SA11.
J, Blackhall +3 more
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Majalah Obat Tradisional, 2022 Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV.
Roihatul Mutiah +3 more
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