Results 71 to 80 of about 283 (118)

PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation

Virulence
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is an important pathogen that seriously endangers pig breeding, causing significant economic losses to the global swine industry.
Yulin Xu, Chenglin Chi, Qihang Xin, Jiang Yu, Yuyu Zhang, Pingping Zhang, Wangli Zheng, Sen Jiang, Wanglong Zheng, Nanhua Chen, Jiaqiang Wu, Jianzhong Zhu   +11 more
doaj   +1 more source

Molecular Characterization of the Porcine Group A Rotavirus NSP2 and NSP5/6 Genes from São Paulo State, Brazil, in 2011/12

The Scientific World Journal, 2013
Rotaviruses are responsible for the acute diarrhea in various mammalian and avian species. The nonstructural proteins NSP2 and NSP5 are involved in the rotavirus replication and the formation of viroplasm, cytoplasmic inclusion bodies within which new ...
Bruna Rocha Passos Barbosa, Nara Thiers Cacciatori Galleti Bernardes, Laila Andreia Rodrigues Beserra, Fábio Gregori   +3 more
doaj   +1 more source

Whole‐Genome Characterization of Rare Artiodactyl‐Like G10P [14] and G8P [14] Rotavirus A Strains Detected in Pediatric Gastroenteritis Cases in Hokkaido Prefecture, Japan

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT Rotavirus alphagastroenteritidis (RVA) is the leading cause of acute gastroenteritis in young children worldwide, as well as in a wide range of animal species. In 2020 and 2022, we identified three unusual RVA strains in pediatric gastroenteritis patients in Hokkaido Prefecture, Japan, using next‐generation sequencing: one G10P[14] strain ...
Akira Takebayashi, Yuya Fukuda, Yoshiki Fujii, Hiroshi Nihira, Minako Kihara, Yoshimasa Kudou, Shuhei Adachi, Noritaka Shintani, Takeshi Tsugawa   +8 more
wiley   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

MicroRNA-7 Inhibits Rotavirus Replication by Targeting Viral NSP5 In Vivo and In Vitro

Viruses, 2020
Rotavirus (RV) is the major causes of severe diarrhea in infants and young children under five years of age. There are no effective drugs for the treatment of rotavirus in addition to preventive live attenuated vaccine.
Yan Zhou, Linlin Chen, Jing Du, Xiaoqing Hu, Yuping Xie, Jinyuan Wu, Xiaochen Lin, Na Yin, Maosheng Sun, Hongjun Li   +9 more
doaj   +1 more source

Role of the Choline‐Binding Protein A in the Ability of Porcine Ligilactobacillus salivarius FFIG58 to Modulate TLR3‐Mediated Intestinal Antiviral Immunity

Food Frontiers, Volume 7, Issue 1, January 2026.
The choline‐binding protein A (CbpA) was shown to mediate adhesion of probiotic Ligilactobacillus salivarius strains to human intestinal epithelial cells (IECs). A knockout mutant lacking the CbpA protein derived from the immunomodulatory porcine strain L. salivarius FFIG58 was obtained. The CbpA is a key surface protein of L.
Yoshiya Imamura, Hikari Yamamuro, Mariano Elean, Lorena Paola Arce, Ryutaro Funabashi, Fernanda Raya Tonetti, Kohtaro Fukuyama, Mikado Tomokiyo, Fu Namai, Sudeb Saha, Wakako Ikeda‐Ohtsubo, Keita Nishiyama, Julio Villena, Haruki Kitazawa   +13 more
wiley   +1 more source

SNRK3.15 Is a Crucial Component of the Sulfur Deprivation Response in Arabidopsis thaliana

Plant Direct, Volume 10, Issue 1, January 2026.
ABSTRACT Sulfate deprivation (–S) results in numerous metabolic and phenotypic alterations in plants. Kinases are often key players in transducing nutrient status signals to molecular components involved in metabolic and developmental program regulation, but despite the physiological importance of sulfur, to date, no signaling kinases have been ...
Anastasia Apodiakou, Elmien Heyneke, Saleh Alseekh, Pinnapat Pinsorn, Sabine Metzger, Stanislav Kopriva, Waltraud Schulze, Rainer Hoefgen, Sarah J. Whitcomb   +8 more
wiley   +1 more source

Novel protein chip for the detection of antibodies against infectious bronchitis virus

BMC Veterinary Research, 2018
Background Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreaks.
Liping Yan, Jianhua Hu, Jing Lei, Zhiyu Shi, Qian Xiao, Zhenwei Bi, Lu Yao, Yuan Li, Yuqing Chen, An Fang, Hui Li, Suquan Song, Min Liao, Jiyong Zhou   +13 more
doaj   +1 more source

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription

Journal of Virology
Coronavirus replication is understood to occur within double membrane vesicles (DMVs) that arise during viral infection. Prior work has determined that these DMVs have characteristic pores formed from the non-structural viral proteins nsp3 and nsp4 ...
Jason K. Perry, Samuel Itskanov, John P. Bilello, Eric B. Lansdon   +3 more
doaj   +1 more source

Characterisation of rearranged NSP5 gene of a human rotavirus.

Acta virologica, 1998
An atypical human rotavirus strain Z10262, isolated from a chronically infected immunodeficient child, displayed an unusual genomic RNA electrophoretic pattern. Besides, Northern blot analysis indicated that this strain contained an abnormally migrating gene 11 equivalent.
E A, Palombo, H C, Bugg, R F, Bishop
openaire   +1 more source