Results 61 to 70 of about 7,665 (202)

Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain [PDF]

, 2008
An ovine rotavirus (OVR) strain, 762, was isolated from a 30-day-old lamb affected with severe gastroenteritis, in Zaragoza, Spain, and the VP4, VP7, VP6, NSP4, and NSP5/NSP6 genes were subsequently characterized molecularly. Strain OVR762 was classified
BANYAI K, BASELGA R, BUONAVOGLIA C, CAFIERO MA, CIARLET M, DE GRAZIA, Simona, HOFFMANN C, LORUSSO E, MARTELLA V., MATTHIJNSSENS J, PARRENO V   +10 more
core   +1 more source

Emergence of Double- and Triple-Gene Reassortant G1P[8]Rotaviruses Possessing a DS-1-Like Backbone after RotavirusVaccine Introduction in Malawi [PDF]

, 2017
To combat the high burden of rotavirus gastroenteritis, multiple African countries have introduced rotavirus vaccines into their childhood immunisation programmes.
Bar-Zeev, N, Chaguza, C, Cunliffe, NA, French, N, Heyderman, RS, Jere, KC, Kumwenda, B, Lowe, J, Miren, I-G, Nakagomi, O, Parashar, UD, Peno, C, Tate, JE, VACSURV Consortium,   +13 more
core   +1 more source

Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

eLife
Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication.
Kejia Zhang, Patrick Eldin, Jessica H Ciesla, Laurence Briant, Jenna M Lentini, Jillian Ramos, Justin Cobb, Joshua Munger, Dragony Fu   +8 more
doaj   +1 more source

Candidate New Rotavirus Species in Sheltered Dogs, Hungary [PDF]

, 2015
We identified unusual rotavirus strains in fecal specimens from sheltered dogs in Hungary by viral metagenomics. The novel rotavirus species displayed limited genome sequence homology to representatives of the 8 rotavirus species, A–H, and qualifies ...
Bányai, Krisztián, Farkas, Szilvia, Fehér, Enikő, Gellért, Ákos, Jakab, Ferenc, Martella, Vito, Marton, Szilvia, Mihalov-Kovács, Eszter, Oldal, Miklós   +8 more
core   +1 more source

SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII

mBio, 2023
The molecular mechanisms underlying how SUD2 recruits other proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to exert its G-quadruplex (G4)-dependent pathogenic function is unknown.
Ying Li, Quanwei Yu, Ridong Huang, Hai Chen, Hequan Ren, Lingling Ma, Yang He, Weimin Li   +7 more
doaj   +1 more source

Hyperphosphorylation of the Rotavirus NSP5 Protein Is Independent of Serine 67, NSP2, or the Intrinsic Insolubility of NSP5 and Is Regulated by Cellular Phosphatases [PDF]

Journal of Virology, 2006
The NSP5 protein is required for viroplasm formation during rotavirus infection and is hyperphosphorylated into 32- to 35-kDa isoforms. Earlier studies reported that NSP5 is not hyperphosphorylated without NSP2 coexpression or deleting the NSP5 N terminus and that serine 67 is essential for NSP5 hyperphosphorylation.
Adrish Sen, Darin Agresti, Erich R. Mackow   +2 more
openaire   +1 more source

SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2

Journal of Cell Science, 2023
ABSTRACT SARS-CoV-2 interferes with antigen presentation by downregulating major histocompatibility complex (MHC) II on antigen-presenting cells, but the mechanism mediating this process is unelucidated. Herein, analysis of protein and gene expression in human antigen-presenting cells reveals that MHC II is downregulated by the SARS-CoV ...
Nima Taefehshokr, Alex Lac, Angela M. Vrieze, Brandon H. Dickson, Peter N. Guo, Catherine Jung, Eoin N. Blythe, Corby Fink, Amena Aktar, Jimmy D. Dikeakos, Gregory A. Dekaban, Bryan Heit   +11 more
openaire   +2 more sources

Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3.

PLoS Pathogens, 2023
Coronaviruses (CoVs) are a family of the largest RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals and humans, imposing great threats to the public safety and animal health.
Yang Wu, Mingwei Li, Jin Tian, Haoxin Yan, Yudi Pan, Hongyan Shi, Da Shi, Jianfei Chen, Longjun Guo, Li Feng   +9 more
doaj   +1 more source

Autophagy Receptor p62 Regulates SARS-CoV-2-Induced Inflammation in COVID-19

Cells, 2023
As autophagy can promote or inhibit inflammation, we examined autophagy-inflammation interplay in COVID-19. Autophagy markers in the blood of 19 control subjects and 26 COVID-19 patients at hospital admission and one week later were measured by ELISA ...
Verica Paunovic, Ljubica Vucicevic, Maja Misirkic Marjanovic, Vladimir Perovic, Biljana Ristic, Mihajlo Bosnjak, Milos Mandic, Danijela Stevanovic, Ljubica Harhaji-Trajkovic, Jovan Lalosevic, Milos Nikolic, Branka Bonaci-Nikolic, Vladimir Trajkovic   +12 more
doaj   +1 more source

Whole-genome characterization of human group C rotaviruses: identification of two lineages in the VP3 gene [PDF]

, 2011
Group C rotavirus (GCRV) is distributed worldwide as an enteric pathogen in humans and animals. However, to date, whole-genome sequences are available only for a human strain (Bristol) and a porcine strain (Cowden).
Chawla-Sarkar, Mamta, Ghosh, Souvik, Ishino, Masaho, Kobayashi, Nobumichi, Kuzuya, Mitsutaka, Paul, Shyamal Kumar, Wang, Yuan-Hong, Yamamoto, Dai, Zhou, Xuan   +8 more
core   +1 more source