Results 61 to 70 of about 5,845 (181)

PDCoV nsp5 cleaves POLDIP3 through its protease activity.

, 2023
(A) PDCoV nsp5 cleaves POLDIP3. IPEC-J2 cells were co-transfected with plasmids of POLDIP3-HA and PDCoV nsp5-Flag or empty vector, and then cell samples were collected at 30 h post-transfection for Western blotting analysis.
Jianfei Chen (3186999), Jin Tian (158712), Haoxin Yan (17108715), Mingwei Li (1914862), Longjun Guo (315268), Yudi Pan (7309513), Hongyan Shi (1988656), Da Shi (1455439), Li Feng (77923), Yang Wu (66682)   +9 more
core   +1 more source

In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir

Nature Communications, 2023
Nirmatrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro), is clinically useful against infection with SARS-CoV-2 including its omicron variants.
Maki Kiso, Yuri Furusawa, Ryuta Uraki, Masaki Imai, Seiya Yamayoshi, Yoshihiro Kawaoka   +5 more
doaj   +1 more source

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Emerging Microbes and Infections, 2021
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication.
Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah Van Tol, Paulina Rudolffi-Soto, Christian Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David Jacques, Benhur Lee, Emma Sierecki, Yann Gambin   +12 more
doaj   +1 more source

Dissecting the role of NSP5 in rotavirus replicative cycle by RNA interference

, 2005
Rotavirus genomes contain 11 double stranded RNA segments. Genome segment 11 encodes for the non structural protein NSP5 and, in some strains, also for the non structural protein NSP6. NSP5 is produced soon after viral infection and undergoes a complex posttranslational hyperphosphorylation process that causes the generation of species characterised by
Campagna, Michela
openaire   +2 more sources

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease. [PDF]

, 2021
The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented health and socio-economic effects for the global population. While different vaccines are now
George Papageorgiou (2705311), Chew Theng Lim (11103186), Jennifer C Milligan (11103168), Joseph F Curran (11103222), Rachel Ulferts (709989), Kang Wei Tan (11103189), Ganka Bineva-Todd (8307225), Michael Howell (228756), Theresa U Zeisner (11103171), Florian Weissmann (9127538), Karim Labib (383844), Mary Wu (11103192), Nicola O'Reilly (230098), Berta Canal (11103207), Dhira Joshi (8259207), Ryo Fujisawa (11103228), Rupert Beale (9596066), Hema Nagaraj (11103240), Tom Deegan (11103237), Christelle Soudy (188161), Clovis Basier (1702723), John FX Diffley (8124071)   +21 more
core   +2 more sources

SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules

Signal Transduction and Targeted Therapy, 2022
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread.
Yi Zheng, Jian Deng, Lulu Han, Meng-Wei Zhuang, Yanwen Xu, Jing Zhang, Mei-Ling Nan, Yang Xiao, Peng Zhan, Xinyong Liu, Chengjiang Gao, Pei-Hui Wang   +11 more
doaj   +1 more source

Viroplasms: Assembly and Functions of Rotavirus Replication Factories

Viruses, 2021
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formation ...
Guido Papa, Alexander Borodavka, Ulrich Desselberger   +2 more
doaj   +1 more source

Fusion of Tags Induces Spurious Phosphorylation of Rotavirus NSP5 [PDF]

Journal of Virology, 2006
Several findings in the paper by Sen et al. entitled “Hyperphosphorylation of the rotavirus NSP5 protein is independent of serine 67 or NSP2, and the intrinsic insolubility of NSP5 is regulated by cellular phosphatases” (5) seem to contradict previous published findings from our laboratory.
Michela Campagna, Oscar R. Burrone
openaire   +1 more source

Substrate specificity of PDCoV nsp5-mediated cleavage.

, 2023
Cleavage sequences of viral and host substrates by PDCoV nsp5 were collected and analyzed. The glutamine (Q) in the P1 position was conserved among the different substrates. (TIF)
Jianfei Chen (3186999), Jin Tian (158712), Haoxin Yan (17108715), Mingwei Li (1914862), Longjun Guo (315268), Yudi Pan (7309513), Hongyan Shi (1988656), Da Shi (1455439), Li Feng (77923), Yang Wu (66682)   +9 more
core   +1 more source

Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

eLife
Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication.
Kejia Zhang, Patrick Eldin, Jessica H Ciesla, Laurence Briant, Jenna M Lentini, Jillian Ramos, Justin Cobb, Joshua Munger, Dragony Fu   +8 more
doaj   +1 more source