Results 81 to 90 of about 283 (118)

Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) infections often trigger oxidative stress and cytokine storms, resulting in significant tissue damage that causes fatalities in piglets and reproductive issues in sows.
Fang Wang, Fructueux Modeste Amona, Yipeng Pang, Qiaoya Zhang, Yuan Liang, Xiaohan Chen, Yongding Ke, Junhao Chen, Chengchuang Song, Yanhong Wang, Zongyun Li, Chunlei Zhang, Xingtang Fang, Xi Chen   +13 more
doaj   +1 more source

Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J

Journal of Virology
Rotavirus (RV) is classified into nine species, A–D and F–J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds.
Ariana Cosic, Melissa Lee, Kurt Tobler, Claudio Aguilar, Cornel Fraefel, Catherine Eichwald   +5 more
doaj   +1 more source

The Role of the Host Cytoskeleton in the Formation and Dynamics of Rotavirus Viroplasms

Viruses
Rotavirus (RV) replicates within viroplasms, membraneless electron-dense globular cytosolic inclusions with liquid–liquid phase properties. In these structures occur the virus transcription, replication, and packaging of the virus genome in newly ...
Janine Vetter, Melissa Lee, Catherine Eichwald   +2 more
doaj   +1 more source

Rotavirus-NSP5 interacts with and hijacks host ATP citrate lyase to viroplasms, enhancing lipid biosynthesis for facilitating rotavirus infection

Virulence
Rotavirus (RV) replication occurs within viroplasms (VMs) and is initiated by two RV non-structural proteins NSP2 and NSP5. Viruses exploit host cellular components for their replication and assembly; however, information on the roles of host proteins in
Ranjana Sharma, Shreya Banerjee, Ratul Datta Chaudhuri, Kaushik Kumar Dey, Animesh Gope, Shin-ichi Miyoshi, Daisuke Imamura, Mamta Chawla-Sarkar   +7 more
doaj   +1 more source

Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation

Veterinary Research
Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the host innate immune response to promote its replication. The ubiquitin–proteasome system (UPS) and ISGylation both play roles in modulating host innate immunity. Within this process,
Zhenbang Zhu, Lulu Chen, Meng Zhang, Qianwen Lin, Yifan Yan, Wenqiang Wang, Wei Wen, Zhendong Zhang, Xiangdong Li   +8 more
doaj   +1 more source

Structure Function Studies of Rotavirus NSP5

, 2008
Rotaviruses, causative agents of gastroenteritis in young animals and humans, are large icosahedral viruses with a complex architecture. The double-stranded RNA (dsRNA) genome composed of 11 segments, that codes for 6 structural and 6 non-structural proteins, is enclosed within three concentric capsid layers.
openaire   +1 more source

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

Science Advances
E166V in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nsp5 protease confers strong resistance to the antiviral component of Paxlovid, nirmatrelvir (NIR), in passaging and clinical samples. In SARS-CoV-2 replicons, E166V drastically decreased Washington (WA1) but not Omicron (BA.1) fitness (20- versus 2-fold), suggesting
Grace Neilsen, Shuiyun Lan, Ryan L. Slack, Zachary C. Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G. Edwards, Huanchun Zhang, Jasper Lee, William A. Cantara, Maria E. Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R. Tedbury, Karen A. Kirby, Raymond F. Schinazi, Stefan G. Sarafianos   +17 more
openaire   +2 more sources

Emergence of a Novel G4P[6] Porcine Rotavirus with Unique Sequence Duplication in NSP5 Gene in China

Animals
Rotavirus is a major causative agent of diarrhoea in children, infants, and young animals around the world. The associated zoonotic risk necessitates the serious consideration of the complete genetic information of rotavirus.
Xia Zhou, Xueyan Hou, Guifa Xiao, Bo Liu, Handuo Jia, Jie Wei, Xiaoyun Mi, Qingyong Guo, Yurong Wei, Shao-Lun Zhai   +9 more
doaj   +1 more source

Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3

Journal of Virology
Porcine deltacoronavirus (PDCoV) is a potential emerging zoonotic pathogen, and studies on the prevalence and pathogenesis of PDCoV are ongoing. The main protease (nsp5) of PDCoV provides an excellent target for antivirals due to its essential and conserved function in the viral replication cycle.
Haixin Huang, Xiaoxiao Lei, Chenchen Zhao, Yan Qin, Yuying Li, Xinyu Zhang, Chengkai Li, Tian Lan, Baopeng Zhao, Wenchao Sun, Huijun Lu, Ningyi Jin   +11 more
openaire   +2 more sources

The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication

mBio
Rotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the synthesis of virus genome segments and their encapsidation in the core shell, followed by the addition of the second layer of the virion.
Janine Vetter, Guido Papa, Kurt Tobler, Javier M. Rodriguez, Manuel Kley, Michael Myers, Mahesa Wiesendanger, Elisabeth M. Schraner, Daniel Luque, Oscar R. Burrone, Cornel Fraefel, Catherine Eichwald   +11 more
doaj   +1 more source