Results 101 to 110 of about 7,665 (202)

Preparatory study for the revaluation of the EQ-5D tariff: methodology report. [PDF]

, 2014
BACKGROUND: EQ-5D is a widely used generic measure of health with a 'tariff', or preference weights, obtained from the general population, using time trade-off (TTO).
Bansback, Nick, Brazier, John, Buckingham, Ken, Cairns, John, Devlin, Nancy, Dolan, Paul, Hole, Arne Risa, Kavetsos, Georgios, Longworth, Louise, Mulhern, Brendan, Rowen, Donna, Tsuchiya, Aki   +11 more
core   +3 more sources

The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2024

EFSA Journal, Volume 23, Issue 11, November 2025.
ABSTRACT This report presents results of surveillance on transmissible spongiform encephalopathies in bovines, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2024 by 27 EU Member States (EU27, MS), the UK (in respect of Northern Ireland, (XI)) and 8 non‐EU reporting countries: Bosnia and Herzegovina, Iceland,
European Food Safety Authority (EFSA), Romolo Nonno, Giuseppe Ru, Roxani Aminalragia‐Giamini, Catalin Iancu, Angel Ortiz‐Pelaez, Kamela Kryemadhi, Francesca Baldinelli   +7 more
wiley   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus [PDF]

, 2012
For decades, cold-adapted, temperature-sensitive (ca/ts) strains of influenza A virus have been used as live attenuated vaccines. Due to their great public health importance it is crucial to understand the molecular mechanism(s) of cold adaptation and ...
Chursov, Andrey, Frishman, Dmitrij, Kondofersky, Ivan, Kopetzky, Sebastian J., Leshchiner, Ignaty, Shneider, Alexander, Theis, Fabian J.   +6 more
core   +1 more source

Spatial Transcriptomics and Single Cell‐RNASeq Reveals Cellular Heterogeneity of SARS‐CoV‐2 in Lung Tissues and Global Mutational Patterns in COVID‐19 Patients

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT RNA viruses have high mutation frequency, quick generation periods and vast population numbers, which promote fast evolution and host environment adaptation. We integrated scRNA‐seq and spatial transcriptomics to profile immune cells and viral gene expression in COVID‐19.
Seyed Taleb Hosseini, Mohammadamin Mahmanzar, Karim Rahimian, Saleha Bayat, Amir Gholamzad, Mahsa Mollapour Sisakht, Amin Farhadi, Donna Lee Kuehu, Youping Deng   +8 more
wiley   +1 more source

Phylogenetic analyses of typical bovine rotavirus genotypes G6, G10, P[5] and P[11] circulating in Argentinean beef and dairy herds [PDF]

, 2013
Group A rotavirus (RVA) is one of the main causes of neonatal calf diarrhea worldwide. RVA strains affecting Argentinean cattle mainly possess combinations of the G6, G10, P[5] and P[11] genotypes.
Badaracco, Alejandra, Bilbao, Gladys Noemí, Fernandez, Fernando, Garaicoechea, Lorena Laura, Louge Uriarte, Enrique Leopoldo, Matthijnssens, J., Odeón, Anselmo Carlos, Parra, G. I., Parreño, Gladys Viviana   +8 more
core   +1 more source

Comparative analysis of ammonia monooxygenase (amoA) genes in the water column and sediment-water interface of two lakes and the Baltic Sea [PDF]

, 2008
The functional gene amoA was used to compare the diversity of ammonia-oxidizing bacteria (AOB) in the water column and sediment-water interface of the two freshwater lakes Plusssee and Schöhsee and the Baltic Sea.
Aakra, Altschul, Avrahami, Beman, Bernhard, Cavari, Christofi, Coci, De Bie, Francis, Francis, Garland, Head, Hooper, Horz, Hughes, Ivanova, Jetten, Jiang, Johannes F. Imhoff, Johnstone, Junier, Juretschko, Karl-Paul Witzel, Kim, Koops, Kowalchuk, Kowalchuk, Könneke, Mahmood, McCaig, McTavish, Molina, Nicolaisen, Nold, Norton, O'Mullan, Ok-Sun Kim, Phillips, Pilar Junier, Prosser, Purkhold, Purkhold, Robarts, Rotthauwe, Schloss, Speksnijder, Stephen, Stephen, Strous, Treusch, Tuomainen, Ward, Ward, Ward, Ward, Webster, Webster   +57 more
core   +1 more source

Comparative in silico analysis of PCR primers suited for diagnostics and cloning of ammonia monooxygenase genes from ammonia-oxidizing bacteria [PDF]

, 2008
Over recent years, several PCR primers have been described to amplify genes encoding the structural subunits of ammonia monooxygenase (AMO) from ammonia-oxidizing bacteria (AOB).
Aakra, Alzerreca, Balasubramanian, Bothe, Calvo, Chain, Head, Holmes, Hoshino, Hyman, Johannes F. Imhoff, Juretschko, Karl-Paul Witzel, Klotz, Konneke, Kowalchuk, Lieberman, Ludwig, McTavish, Mobarry, Molina, Nicolaisen, Nold, Norton, Ok-Sun Kim, Okano, Petra Limburg, Pilar Junier, Prosser, Purkhold, Purkhold, Rotthauwe, Sinigalliano, Stephen, Thomas Junier, Treusch, Verónica Molina, Wagner, Wagner, Webster   +39 more
core   +1 more source

SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses

Nature Communications, 2020
Currently very little is known about how our immune system responds to SARS-CoV-2 infection. Here the authors generate a SARS-CoV-2 proteome microarray for profiling of IgG and IgM responses to COVID-19 in patients and find significant responses to ORF9b
He-wei Jiang, Yang Li, Hai-nan Zhang, Wei Wang, Xiao Yang, Huan Qi, Hua Li, Dong Men, Jie Zhou, Sheng-ce Tao   +9 more
doaj   +1 more source

Stability of local secondary structure determines selectivity of viral RNA chaperones [PDF]

, 2018
To maintain genome integrity, segmented double-stranded RNA viruses of the Reoviridae family must accurately select and package a complete set of up to a dozen distinct genomic RNAs. It is thought that the high fidelity segmented genome assembly involves
Barth, A, Borodavka, A, Bravo, JPK, Calabrese, AN, Cockburn, JJB, Lamb, DC, Mojzes, P, Tuma, R   +7 more
core   +1 more source