Results 111 to 120 of about 5,845 (181)
Conserved catalytic residues (Cys) are observed among different coronaviruses nsp5.
, 2023 Nsp5s from PDCoV, PEDV, TGEV and SARS-CoV-2, were collected and the conserved catalytic residue Cys144 (in the red box, numbering based on PDCoV nsp5) was analyzed by the DNAMAN software. (TIF)
Jianfei Chen (3186999) +9 more
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APMIS, Volume 133, Issue 12, December 2025.ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson +5 more
wiley +1 more source
, 2023 Coronaviruses nsp5-mediated cleavage abolishes the antiviral activity of POLDIP3 to evade host cell innate immune response.
Jianfei Chen (3186999) +9 more
core +1 more source
Characterisation of rearranged NSP5 gene of a human rotavirus.
Acta virologica, 1998 An atypical human rotavirus strain Z10262, isolated from a chronically infected immunodeficient child, displayed an unusual genomic RNA electrophoretic pattern. Besides, Northern blot analysis indicated that this strain contained an abnormally migrating gene 11 equivalent.
E A, Palombo, H C, Bugg, R F, Bishop
openaire +1 more source
Construction of NSP5-based protein association platform.
, 2016 (A) Principle of the NSP5-based protein association platform. Plasmids expressing NS80 fragments (bait protein) fused to GFP-NSP5 and viral proteins (prey protein) are co-transfected into Vero cells.
Qingxiu Chen (734638) +4 more
core
Prediction of PDCoV nsp5-mediated cleavage site for POLDIP3.
, 2023 (A to C) The nsp5-mediated cleavage sites were predicted by using the online NetCorona-1.0 software (https://services.healthtech.dtu.dk/service.php?NetCorona-1.0) and the glutamine at the position of 176 (Q176) was predicted to be the potential cleavage ...
Jianfei Chen (3186999) +9 more
core +1 more source
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses
Nature Communications, 2020 Currently very little is known about how our immune system responds to SARS-CoV-2 infection. Here the authors generate a SARS-CoV-2 proteome microarray for profiling of IgG and IgM responses to COVID-19 in patients and find significant responses to ORF9b
He-wei Jiang +9 more
doaj +1 more source
, 2008 Sequencing and reversion analysis of murine hepatitis virus (MHV) temperature-sensitive (ts) viruses has identified putative ts mutations in the replicase nonstructural proteins (nsp's) of these coronaviruses.
Lu, X. +4 more
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Potential Inhibition of Melaleuca leucadendron L. Compounds Against the NSP5 SARS CoV-2 Protein
, 2022 COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome (SARS-CoV-2), causing a global health emergency as a pandemic disease.
Melani, Ira Resmi +7 more
core +1 more source
Structural and Functional Analysis of Coronavirus Cysteine Protease Nsp5
, 2013 Coronaviruses (CoV) are positive-strand RNA viruses that encode large replicase polyproteins that are processed by two or three viral proteases to yield intermediate and mature nonstructural proteins (nsps).
Stobart, Christopher Colin
core