Results 91 to 100 of about 7,665 (202)

Phosphoproteomic Analysis Reveals the Importance of Kinase Regulation During Orbivirus Infection. [PDF]

, 2017
Bluetongue virus (BTV) causes infections in wild and domesticated ruminants with high morbidity and mortality and is responsible for significant economic losses in both developing and developed countries.
Emmott, Edward, Mohl, Bjorn-Patrick, Roy, Polly   +2 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

Molecular Characterization of the Porcine Group A Rotavirus NSP2 and NSP5/6 Genes from São Paulo State, Brazil, in 2011/12

The Scientific World Journal, 2013
Rotaviruses are responsible for the acute diarrhea in various mammalian and avian species. The nonstructural proteins NSP2 and NSP5 are involved in the rotavirus replication and the formation of viroplasm, cytoplasmic inclusion bodies within which new ...
Bruna Rocha Passos Barbosa, Nara Thiers Cacciatori Galleti Bernardes, Laila Andreia Rodrigues Beserra, Fábio Gregori   +3 more
doaj   +1 more source

MicroRNA-7 Inhibits Rotavirus Replication by Targeting Viral NSP5 In Vivo and In Vitro

Viruses, 2020
Rotavirus (RV) is the major causes of severe diarrhea in infants and young children under five years of age. There are no effective drugs for the treatment of rotavirus in addition to preventive live attenuated vaccine.
Yan Zhou, Linlin Chen, Jing Du, Xiaoqing Hu, Yuping Xie, Jinyuan Wu, Xiaochen Lin, Na Yin, Maosheng Sun, Hongjun Li   +9 more
doaj   +1 more source

Characterization of rotavirus NSP2/NSP5 interactions and the dynamics of viroplasm formation

Journal of General Virology, 2004
Viroplasms are discrete structures formed in the cytoplasm of rotavirus-infected cells and constitute the replication machinery of the virus. The non-structural proteins NSP2 and NSP5 localize in viroplasms together with other viral proteins, including the polymerase VP1, VP3 and the main inner-core protein, VP2. NSP2 and NSP5 interact with each other,
Catherine, Eichwald, José Francisco, Rodriguez, Oscar R, Burrone   +2 more
openaire   +2 more sources

Structural insights into SARS‐CoV‐2 nonstructural protein 4 (nsp4) biogenesis

Protein Science, Volume 34, Issue 11, November 2025.
Abstract The SARS‐CoV‐2 virus—responsible for the COVID‐19 pandemic—requires a replication–transcription complex (RTC) for efficient RNA synthesis and viral propagation. One critical RTC component is nonstructural protein 4 (nsp4), a multipass transmembrane (TM) protein implicated in endoplasmic reticulum (ER) membrane rearrangements and double ...
José M. Acosta‐Cáceres, Fabio Lolicato, Laura Gadea‐Salom, Juan Ortiz‐Mateu, Diego Belda, Luis Martínez‐Gil, María Jesús García‐Murria, Ismael Mingarro   +7 more
wiley   +1 more source

Novel protein chip for the detection of antibodies against infectious bronchitis virus

BMC Veterinary Research, 2018
Background Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreaks.
Liping Yan, Jianhua Hu, Jing Lei, Zhiyu Shi, Qian Xiao, Zhenwei Bi, Lu Yao, Yuan Li, Yuqing Chen, An Fang, Hui Li, Suquan Song, Min Liao, Jiyong Zhou   +13 more
doaj   +1 more source

Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells [PDF]

, 2011
Background Severe Acute Respiratory Syndrome (SARS) is a severe respiratory illness caused by a novel virus, the SARS coronavirus (SARS-CoV). 3C-like protease (3CLpro) of SARS-CoV plays a role in processing viral polypeptide precursors and is
Hsien-Hua Liao, Yao-Chen Wang, Miles Chen, Hsien-Yu Tsai, Johnson Lin, Shui-Tein Chen, Gregory Tsay, Sun-Long Cheng   +7 more
core   +1 more source

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

Acta Crystallographica Section D, Volume 81, Issue 11, Page 630-645, November 2025.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz, Jan Wollenhaupt, Melanie Oelker, Paula Fröling, Uwe Mueller, Anke Deckers, Christoph Grathwol, Stefan Bräse, Nicole Jung, Manfred S. Weiss   +9 more
wiley   +1 more source

Rotavirus infection [PDF]

Rotavirus infection causing gastroenteritis is one of the major health concerns throughout the world. Millions of children are affected by the disease.
Surendran, Sankar
core   +1 more source