Results 91 to 100 of about 283 (118)
Journal of VirologyAutophagy plays a critical role in viral replication and the regulation of host immune responses. Although the TOM1-TOLLIP complex has been implicated in immune signaling, cargo trafficking, and endocytosis, its role in viral replication has not been ...
Qingxiang Zhang +6 more
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Studies on rotavirus NSP5 phosphorylation and its interaction with NSP2
, 2003 Rotavirus NSP5 is a non-structural protein that localises in cytoplasmic viroplasms of infected cells. NSP5 interacts with NSP2 and undergoes a complex posttranslational hyper-phosphorylation , generating species with reduced PAGE mobility. This process has been suggested to be due in part to autophosphorylation.
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Interaction of rotavirus nonstructural protein NSP5 with the viral replication complex
, 2008 Rotavirus morphogenesis starts in intracellular inclusion bodies called viroplasms, where synthesis of the11 dsRNA genome segments and their packaging in new viral particles take place. RNA replication is mediated by several viral proteins, of which VP1, the RNA-dependent RNA polymerase, and VP2, the core scaffolding protein, were shown to be ...
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Functional studies on the rotavirus non-structural proteins NSP5 and NSP6 [PDF]
The rotavirus replication cycle has not been fully characterised, one vital\ud stage of virus replication involves large cytoplasmic occlusion bodies termed\ud viroplasms. These are the sites of synthesis and replication of dsRNA, packaging of\ud viral RNA into newly synthesized cores and the formation of double-shelled previrions.\ud The detailed ...
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Dissecting the role of NSP5 in rotavirus replicative cycle by RNA interference
, 2005 Rotavirus genomes contain 11 double stranded RNA segments. Genome segment 11 encodes for the non structural protein NSP5 and, in some strains, also for the non structural protein NSP6. NSP5 is produced soon after viral infection and undergoes a complex posttranslational hyperphosphorylation process that causes the generation of species characterised by
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Structural Organisation of the Rotavirus Nonstructural Protein NSP5
Journal of Molecular Biology, 2011Rotavirus is one of the leading agents of gastroenteritis worldwide. During infection, viral factories (viroplasms) are formed. The rotavirus nonstructural proteins NSP5 and NSP2 are the major building blocks of viroplasms; however, NSP5 function and organisation remain elusive. In this report, we present a structural characterisation of NSP5.
Didier Poncet, Malika Ouldali
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An ATPase activity associated with the rotavirus phosphoprotein NSP5
Virology, 2007 Interactions between NSP5 and NSP2 drive the formation of viroplasms, sites of genome replication and packaging in rotavirus-infected cells. The serine-threonine-rich NSP5 transitions between hypo- and hyper-phosphorylated isomers during the replication cycle. In this study, we determined that purified recombinant NSP5 has a Mg2+-dependent ATP-specific
, John Patton
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Conserved Rotavirus NSP5 and VP2 Domains Interact and Affect Viroplasm
Journal of Virology, 2020 Alternative treatments to combat rotavirus infection are a requirement for susceptible communities where vaccines cannot be applied. This demand is urgent for newborn infants, immunocompromised patients, adults traveling to high-risk regions, and even for the livestock industry.
Mathias Ackermann +2 more
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Porcine Deltacoronavirus nsp5 Cleaves DCP1A To Decrease Its Antiviral Activity [PDF]
Journal of Virology, 2020 Interferon (IFN)-stimulated gene (ISG) induction through IFN signaling is important to create an antiviral state and usually directly inhibits virus infection. The present study first demonstrated that PDCoV nsp5 can cleave mRNA-decapping enzyme 1a (DCP1A) to attenuate its antiviral activity.
Shaobo Xiao, Liurong Fang, Dang Wang
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