Results 1 to 10 of about 332 (132)
Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]
mBio, 2010 Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser +3 more
doaj +3 more sources
Rotavirus enterotoxin NSP4 has mucosal adjuvant properties
Vaccine, 2010 Rotavirus nonstructural protein 4 (NSP4) is a protein with pleiotropic properties. It functions in rotavirus morphogenesis, pathogenesis, and is the first described viral enterotoxin. Since many bacterial toxins function as potent mucosal adjuvants, we evaluated whether baculovirus-expressed recombinant simian rotavirus SA11 NSP4 possesses adjuvant ...
Sue Crawford, Nadim Ajami, Mary Estes
exaly +4 more sources
Virology, 2004 Using recombinant baculoviruses expressing rotavirus NSP4 [A], [B], [C], and [D] genotypes of bovine, porcine, human, simian, or murine origin, we analyzed serum antibody responses to NSP4s in gnotobiotic calves and piglets infected by the oral/alimentary or intraamniotic route with bovine (NSP4[A]) (Wyatt, R.G., Mebus, C.A., Yolken, R.H., Kalica, A.R.,
Lijuan Yuan +2 more
exaly +3 more sources
Viruses, 2022 Ubiquitination plays a major role in immune regulation after viral infection. An alternatively spliced porcine E3 ubiquitin ligase RNF122 promoted PRRSV infection and upregulated in PRRSV-infected PAM cells was identified.
Ruiqi Sun +9 more
doaj +1 more source
تولید آنتی بادی پلی کلونال بر اساس پپتید علیه پروتئین غیر ساختاری NSP4) 4) روتا ویروس گاوی [PDF]
Archives of Razi Institute, 2015 پروتئین غیرساختاری 4 (NSP4) روتا ویروس، پروتئینی است با عملکرد چندگانه که نقش مهمی در مورفوژنز و آثار سیتوپاتیک مرتبط با مرگ سلول دارد. با این حال، تمامی اثرات بیولوژیکی پروتئین 4NSP به طور کامل مشخص نشده است.
هادی رضوی +4 more
doaj +1 more source
Silencing of the rotavirus NSP4 protein decreases the incidence of biliary atresia in murine model. [PDF]
PLoS ONE, 2011 Biliary atresia is a common disease in neonates which causes obstructive jaundice and progressive hepatic fibrosis. Our previous studies indicate that rotavirus infection is an initiator in the pathogenesis of experimental biliary atresia (BA) through ...
Jiexiong Feng +4 more
doaj +1 more source
Structural Plasticity of the Coiled-Coil Domain of Rotavirus NSP4 [PDF]
Journal of Virology, 2014 ABSTRACT Rotavirus (RV) nonstructural protein 4 (NSP4) is a virulence factor that disrupts cellular Ca 2+ homeostasis and plays multiple roles regulating RV replication and the pathophysiology of RV-induced diarrhea.
Narayan P, Sastri +7 more
openaire +2 more sources
nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity
Journal of Virology, 2021 A key element of every virus with an RNA genome is the RNA replicase. Understanding the principles of RNA replicase formation and functioning is therefore crucial for understanding and responding to the emergence of new viruses.
BROCARD, MICHELE +9 more
openaire +4 more sources
Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach
Innovative Biosystems and Bioengineering, 2023 Background. Alphaviral diseases are an economic burden all over the world due to their chronicity and distribution worldwide. The glycoproteins E1 and E2 are important for binding to the surface of the host cell by interacting with the receptors and non ...
Maneesha Sharma +3 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2020 Rotavirus A (RVA) causes viral gastroenteritis in humans and animals, including calves, piglets, and foals. The current study reports the genetic characterization of the full-length enterotoxin gene, NSP4, from caprine and ovine species.
Shubhankar Sircar +8 more
doaj +1 more source