Results 21 to 30 of about 332 (132)

Porcine reproductive and respiratory syndrome virus nsp4 positively regulates cellular cholesterol to inhibit type I interferon production

Redox Biology, 2022
Cellular cholesterol plays an important role in the life cycles of enveloped viruses. Previous studies by our group and other groups have demonstrated that the depletion of cellular cholesterol by methyl-β-cyclodextrin (MβCD) reduces the proliferation of
Wenting Ke, Yanrong Zhou, Yinan Lai, Siwen Long, Liurong Fang, Shaobo Xiao   +5 more
doaj   +1 more source

Rotavirus NSP4: Cell type-dependent transport kinetics to the exofacial plasma membrane and release from intact infected cells

Virology Journal, 2011
Background Rotavirus NSP4 localizes to multiple intracellular sites and is multifunctional, contributing to RV morphogenesis, replication and pathogenesis.
Parr Rebecca D, Mitchel DeAnne M, McIntosh Avery, Williams Cecelia V, Storey Stephen M, Gibbons Thomas F, Schroeder Megan E, Schroeder Friedhelm, Ball Judith M   +8 more
doaj   +1 more source

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2

ACS Omega, 2023
The human Betacoronavirus SARS-CoV-2 is a novel pathogen claiming millions of lives and causing a global pandemic that has disrupted international healthcare systems, economies, and communities. The virus is fast mutating and presenting more infectious but less lethal versions. Currently, some small-molecule therapeutics have received FDA emergency use
Abdul-Rahman Azizogli, Varun Pai, Francesco Coppola, Roya Jafari, Joseph B. Dodd-o, Rohan Harish, Bhavani Balasubramanian, Jatin Kashyap, Amanda M. Acevedo-Jake, Petr Král, Vivek A. Kumar   +10 more
openaire   +2 more sources

Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate

Scientific Reports, 2022
Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile and arthritogenic illness with no effective treatments available. The development of effective therapeutic strategies could be significantly accelerated with detailed
Marjorie C. L. C. Freire, Luis G. M. Basso, Luis F. S. Mendes, Nathalya C. M. R. Mesquita, Melina Mottin, Rafaela S. Fernandes, Lucca R. Policastro, Andre S. Godoy, Igor A. Santos, Uriel E. A. Ruiz, Icaro P. Caruso, Bruna K. P. Sousa, Ana C. G. Jardim, Fabio C. L. Almeida, Laura H. V. G. Gil, Carolina H. Andrade, Glaucius Oliva   +16 more
doaj   +1 more source

Identification of RACK1 as a novel regulator of non-structural protein 4 of chikungunya virus

Acta Biochimica et Biophysica Sinica
Chikungunya virus (CHIKV) is a neglected arthropod-borne and anthropogenic alphavirus. Over the past two decades, the CHIKV distribution has undergone significant changes worldwide, from the original tropics and subtropics regions to temperate regions ...
Yan Yao, Zhang Fengyuan, Zou Meng, Chen Hongyu, Xu Jingwen, Lu Shuaiyao, Liu Hongqi   +6 more
doaj   +1 more source

Molecular characterisation of the NSP4 gene of group A human rotavirus G2P[4] strains circulating in São Paulo, Brazil, from 1994 and 2006 to 2010

Memorias do Instituto Oswaldo Cruz, 2015
Group A human rotaviruses (HuRVA) are causative agents of acute gastroenteritis. Six viral structural proteins (VPs) and six nonstructural proteins (NSPs) are produced in RV-infected cells.
Jéssica Wildgrube Bertol, Maria Clara Duarte Fregolente, Thabata Alessandra Ramos Caruzo, Márcio José da Silva, Veridiana Munford, Marco Aurélio Palazzi Sáfadi, Maria Lucia Rácz, Maria Silvia Viccari Gatti   +7 more
doaj   +1 more source

The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel [PDF]

Scientific Reports, 2017
AbstractViroporins are small virus-encoded ion channel proteins. Most viroporins are monovalent selective cation channels, with few showing the ability to conduct divalent cations, like calcium (Ca2+). Nevertheless, some viroporins are known to disrupt host cell Ca2+ homeostasis, which is critical for virus replication and pathogenesis.
Thieng Pham, Jacob L. Perry, Timothy L. Dosey, Anne H. Delcour, Joseph M. Hyser   +4 more
openaire   +2 more sources

Rotavirus NSP4_114-135 peptide has no direct, specific effect on chloride transport in rabbit brush-border membrane

Virology Journal, 2006
The direct effect of the rotavirus NSP4114-135 and Norovirus NV464-483 peptides on 36Cl uptake was studied by using villus cell brush border membrane (BBM) isolated from young rabbits. Both peptides inhibited the Cl-/H+ symport activity about equally and
Vasseur Monique, Lorrot Mathie
doaj   +1 more source

Genetic Analysis of Murine Hepatitis Virus nsp4 in Virus Replication [PDF]

Journal of Virology, 2007
ABSTRACT Coronavirus replicase polyproteins are translated from the genomic positive-strand RNA and are proteolytically processed by three viral proteases to yield 16 mature nonstructural proteins (nsp1 to nsp16). nsp4 contains four predicted transmembrane-spanning regions (TM1, -2, -3, and -4), demonstrates characteristics of an
Jennifer S, Sparks, Xiaotao, Lu, Mark R, Denison   +2 more
openaire   +2 more sources

Structural insights into inhibition of PRRSV Nsp4 revealed by structure-based virtual screening, molecular dynamics, and MM-PBSA studies

Journal of Biological Engineering, 2022
Background Porcine reproductive and respiratory syndrome respiratory sickness in weaned and growing pigs, as well as sow reproductive failure, and its infection is regarded as one of the most serious swine illnesses worldwide.
Rajesh Kumar Pathak, Young-Jun Seo, Jun-Mo Kim   +2 more
doaj   +1 more source