Results 11 to 20 of about 332 (132)

Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells

Virology Journal, 2011
Background Nonstructural glycoprotein 4 (NSP4) encoded by rotavirus is the only viral protein currently believed to function as an enterotoxin. NSP4 is synthesized as an intracellular transmembrane glycoprotein and as such is essential for virus assembly.
Didsbury Alicia, Wang Carol, Verdon Daniel, Sewell Mary A, McIntosh Julie D, Taylor John A   +5 more
doaj   +1 more source

Analysis of Rotavirus NSP4 Genotypes and Age-Dependent Antibody Response against NSP4 in Shanghai, China

Japanese Journal of Infectious Diseases, 2010
This study aimed to determine the genotypes of NSP4 in children with acute rotavirus diarrhea and evaluate serum antibody titers to NSP4 in different age groups in Shanghai, China. A total of 171 stool specimens were collected from hospitalized patients < or =5 years of age who had acute rotavirus diarrhea between January 2003 and December 2006.
Xu, Menghua, Fu, Yongfeng, Sun, Jiae, Zhang, Junqi, Feng, Meng, Cheng, Xunjia, Xu, Jin   +6 more
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PEGylated substrates of NSP4 protease: A tool to study protease specificity [PDF]

Scientific Reports, 2016
AbstractHerein we present the synthesis of a novel type of peptidomimetics composed of repeating diaminopropionic acid residues modified with structurally diverse heterobifunctional polyethylene glycol chains (abbreviated as DAPEG). Based on the developed compounds, a library of fluorogenic substrates was synthesized.
Wysocka, M., Gruba, N., Grzywa, R., Giełdoń, A., Bąchor, R., Brzozowski, K., Sienczyk, M., Jenne, D., Szewczuk, Z., Rolka, K., Lesner, A.   +10 more
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Genetic Characterization of the Rotavirus Nonstructural Protein, NSP4

Virology, 1997
The rotavirus nonstructural protein NSP4 plays a role in viral assembly by acting as an intracellular receptor for single-shelled particles and assisting in the translocation of these particles across the endoplasmic reticulum. Recently, NSP4 has been implicated in rotavirus virulence and is thought to act as an enterotoxin which triggers chloride ...
Kirkwood, Carl D., Palombo, Enzo A.
openaire   +2 more sources

The Semliki‐Forest‐virus‐specific nonstructural protein nsP4 is an autoproteinase [PDF]

European Journal of Biochemistry, 1990
The Semliki‐Forest‐virus‐specific nonstructural proteins are translated as a large polyprotein (2431 amino acid residues), from which the mature polymerase components nsP1, nsP2, nsP3 and nsP4 are released by proteolytic cleavages. The complete ns polyprotein (P1234) can be cleaved in two alternative ways yielding either P123 (with sequences of nsP1 ...
Takkinen, Kristiina, Peränen, Johan, Keränen, Sirkka, Söderlund, Hans, Kääriäinen, Leevi   +4 more
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Molecular characterization of the NSP4 gene of human group A rotavirus samples from the West Central region of Brazil

Memorias do Instituto Oswaldo Cruz, 2008
Nonstructural protein 4 (NSP4), encoded by group A rotavirus genome segment 10, is a multifunctional protein and the first recognized virus-encoded enterotoxin.
Talissa de Moraes Tavares, Wilia Marta Elsner Diederichsen de Brito, Fabíola Souza Fiaccadori, Erika Regina Leal de Freitas, Juliana Alves Parente, Paulo Sérgio Sucasas da Costa, Loreny Gimenes Giugliano, Márcia Sueli Assis Andreasi, Célia Maria Almeida Soares, Divina das Dôres de Paula Cardoso   +9 more
doaj   +1 more source

Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity.

PLoS ONE, 2013
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease in pigs caused by PRRS virus (PRRSV). Although PRRSV infection-induced cell apoptosis has been established, the related viral protein is still unknown.
Zhitao Ma, Yalan Wang, Haiyan Zhao, Ao-Tian Xu, Yongqiang Wang, Jun Tang, Wen-hai Feng   +6 more
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Genomic and evolutionary characteristics of G9P[8], the dominant group a rotavirus in China (2016–2018)

Frontiers in Microbiology, 2022
G9P[8] became the predominant rotavirus A (RVA) genotype in China in 2012. To evaluate its genetic composition at the whole-genome level, 115 G9P[8] RVA strains isolated from children under 5 years old were sequenced and characterized.
Xiafei Liu, Mengxuan Wang, Shan Li, Shan Li, Jingxin Li, Jinbo Xiao, Huiying Li, Qing Zhang, Xiangyu Kong, Hong Wang, Dandi Li, Zhaojun Duan   +11 more
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Studies of the Role for NSP4 in the Pathogenesis of Homologous Murine Rotavirus Diarrhea [PDF]

The Journal of Infectious Diseases, 1998
A rotavirus (RV) nonstructural protein, NSP4, has recently been proposed to function as an enterotoxin in the pathogenesis of RV diarrhea. The role of NSP4 in the pathogenesis of RV diarrhea was examined by infecting cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice with virulent murine RV and by comparing deduced amino acid ...
J, Angel, B, Tang, N, Feng, H B, Greenberg, D, Bass   +4 more
openaire   +2 more sources

Mutation Distribution in the NSP4 Protein in Rotaviruses Isolated from Mexican Children with Moderate to Severe Gastroenteritis

Viruses, 2013
The NSP4 protein is a multifunctional protein that plays a role in the morphogenesis and pathogenesis of the rotavirus. Although NSP4 is considered an enterotoxin, the relationship between gastroenteritis severity and amino acid variations in NSP4 of the
Juan F. Contreras, Reyes S. Tamez, Carlos E. Hernández, Cristina Rodríguez, Guadalupe González-Ochoa, Griselda E. Menchaca   +5 more
doaj   +1 more source