Results 31 to 40 of about 332 (132)

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4. [PDF]

PLoS ONE, 2015
Human neutrophil serine protease 4 (NSP4), also known as PRSS57, is a recently discovered fourth member of the neutrophil serine proteases family. Although its biological function is not precisely defined, it is suggested to regulate neutrophil response ...
Paulina Kasperkiewicz, Marcin Poreba, Scott J Snipas, S Jack Lin, Daniel Kirchhofer, Guy S Salvesen, Marcin Drag   +6 more
doaj   +1 more source

NSP4, an elastase-related protease in human neutrophils with arginine specificity [PDF]

Proceedings of the National Academy of Sciences, 2012
Neutrophil serine proteases (NSPs) in cytoplasmic granules of neutrophils are regarded as important antimicrobial defense weapons after engulfment and exposure of pathogens to the content of primary granules. Despite intensive studies on neutrophils during the last three decades, only three active serine proteases, neutrophil ...
Perera, Natascha C., Schilling, Oliver, Kittel, H., Back, Walter, Kremmer, Elisabeth, Jenne, Dieter E.   +5 more
openaire   +4 more sources

Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors

Communications Biology, 2023
A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MProWT) from precursor polyproteins. Upon expression, a model precursor of MProWT mediates its own release at its termini rapidly to yield a mature ...
Annie Aniana, Nashaat T. Nashed, Rodolfo Ghirlando, Leighton Coates, Daniel W. Kneller, Andrey Kovalevsky, John M. Louis   +6 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Rotavirus Glycoprotein NSP4 Is a Modulator of Viral Transcription in the Infected Cell [PDF]

Journal of Virology, 2005
ABSTRACT The outer shell of the rotavirus triple-layered virion is lost during cell entry, yielding a double-layered particle (DLP) that directs synthesis of viral plus-strand RNAs. The plus-strand RNAs act as templates for synthesis of the segmented double-stranded RNA (dsRNA) genome in viral inclusion bodies (viroplasms).
Lynn S, Silvestri, M Alejandra, Tortorici, Rodrigo, Vasquez-Del Carpio, John T, Patton   +3 more
openaire   +2 more sources

Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane Pairing

Viruses, 2018
Positive-strand RNA viruses, such as coronaviruses, induce cellular membrane rearrangements during replication to form replication organelles allowing for efficient viral RNA synthesis.
Nicole Doyle, Benjamin W. Neuman, Jennifer Simpson, Philippa C. Hawes, Judith Mantell, Paul Verkade, Hasan Alrashedi, Helena J. Maier   +7 more
doaj   +1 more source

Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. [PDF]

PLoS ONE, 2009
BACKGROUND:The replication of coronaviruses takes place on cytoplasmic double membrane vesicles (DMVs) originating in the endoplasmic reticulum (ER). Three trans-membrane non-structural proteins, nsp3, nsp4 and nsp6, are understood to be membrane anchors
Xiaoling Xu, Zhiyong Lou, Yanlin Ma, Xuehui Chen, Zhangsheng Yang, Xiaohang Tong, Qi Zhao, Yuanyuan Xu, Hongyu Deng, Mark Bartlam, Zihe Rao   +10 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Structural insights into type I and type II of nsp4 porcine reproductive and respiratory syndrome virus (nsp4 PRRSV) by molecular dynamics simulations

Journal of Molecular Graphics and Modelling, 2017
Porcine reproductive and respiratory virus (PRRSV) causes major economic concerns for the swine industry worldwide. We have performed molecular dynamics simulations (MD) and principle component analysis (PCA) to investigate the role of the catalytic triad and conformational dynamics of type I and type II of nsp4 PRRSV.
Aeksiri, Niran, Jantafong, Tippawan
openaire   +2 more sources

Structure of the C-terminal domain of nsp4 from feline coronavirus [PDF]

Acta Crystallographica Section D Biological Crystallography, 2009
Coronaviruses are a family of positive-stranded RNA viruses that includes important pathogens of humans and other animals. The large coronavirus genome (26-31 kb) encodes 15-16 nonstructural proteins (nsps) that are derived from two replicase polyproteins by autoproteolytic processing.
Manolaridis, I., Wojdyla, J. A., Panjikar, S., Snijder, E. J., Gorbalenya, A. E., Berglind, H., Nordlund, P., Coutard, B., Tucker, P. A.   +8 more
openaire   +3 more sources