Results 51 to 60 of about 332 (132)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Peptide based polyclonal antibody production against bovine rotavirus non structure protein4 (NSP4)

Archives of Razi Institute, 2015
The rotavirus nonstructural protein 4 (NSP4), is a multi functional protein that play key role in both viral morphogenesis and cytopathic effect associated with cell death. However, the complete biological effect of NSP4 remains to be clarified. Since to
Goodarzi1, Z, Soleimanjahi, H, Saberfar, E, Teimoori, A, Razavi, H   +4 more
doaj  

Viperin, an IFN-Stimulated Protein, Delays Rotavirus Release by Inhibiting Non-Structural Protein 4 (NSP4)-Induced Intrinsic Apoptosis

Viruses, 2021
Viral infections lead to expeditious activation of the host’s innate immune responses, most importantly the interferon (IFN) response, which manifests a network of interferon-stimulated genes (ISGs) that constrain escalating virus replication by ...
Rakesh Sarkar, Satabdi Nandi, Mahadeb Lo, Animesh Gope, Mamta Chawla-Sarkar   +4 more
doaj   +1 more source

Genotyping of VP6 and NSP4 genes and molecular characterization of NSP4 gene of unusual Rotavirus group A isolated from children with acute gastroenteritis

, 2023
Abstract Group A Rotavirus (RVA), which causes acute gastroenteritis (AGE) in children worldwide, is categorized mainly based on VP7 (genotype G) and VP4 (genotype P) genes. Genotypes that circulate at < 1% are considered unusual. Important genes are also VP6 (genotype I) and NSP4 (genotype E).
Charilaos Dellis, Elizabeth-Barbara Tatsi, Dimitra-Maria Koukou, Filippos Filippatos, Evangelia-Eirini Vetouli, Athanasios Michos, Vasiliki syriopouou   +6 more
openaire   +1 more source

Effects of Rotavirus NSP4 on the Immune Response and Protection of Rotavirus-Norovirus Recombinant Subunit Vaccines in Different Immune Pathways

Vaccines
Diarrheal disease continues to be a major cause of global morbidity and mortality among children under 5 years of age. To address the current issues associated with oral attenuated rotavirus vaccines, the study of parenteral rotavirus vaccines has ...
Jingping Hu, Jinyuan Wu, Han Cao, Ning Luan, Kangyang Lin, Haihao Zhang, Dandan Gao, Zhentao Lei, Hongjun Li, Cunbao Liu   +9 more
doaj   +1 more source

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

mLife, Volume 5, Issue 3, Page 339-354, June 2026.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang   +7 more
wiley   +1 more source

Uso de benzoato de estradiol o GnRH en vaquillas sincronizadas con progesterona y PGF2

Tecnociencia Chihuahua, 2020
El objetivo fue evaluar el benzoato de estradiol (BE) o GnRH en tiempo al estro (TE; h), porcentajes de estros (PE) y gestación (PG), área del cuerpo lúteo (aCL; cm2) y niveles séricos de progesterona (NSP4; ng/mL) en vaquillas sincronizadas
Alberto Flores-Mariñalarena, Efraín Enríquez-Bueno, Alfredo Anchondo-Garay, Alfredo Anchondo-Garay, Juan Alberto Grado-Ahuir, Carlos Rodríguez-Muela, José Alejandro Ramírez-Godínez   +6 more
doaj  

Structural analysis of the flexibility of the Ubl2 domain within the papain‐like protease of SARS‐CoV‐2

Acta Crystallographica Section F, Volume 82, Issue 6, Page 222-230, June 2026.
The ubiquitin‐like domain 2 (Ubl2) of the SARS‐CoV‐2 virus is necessary for the stability and catalytic efficiency of its papain‐like protease (PLpro). Our crystallographic study reveals that the Ubl2 domain exhibits notable flexibility and can adopt a conformation that places itself away from the PLpro catalytic domain, representing a new conformation
Gian Luca Freiherr von Scholley, Martina Schaefer, Mark D. Tully, Marc-Andre Hograindleur, Montserrat Soler-López, Roman C. Hillig, Christoph Mueller-Dieckmann, Eaazhisai Kandiah   +7 more
wiley   +1 more source

Fragment‐Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
This paper by Kollár et al. reports a covalent fragment linking study against the SARS‐CoV‐2 main protease (3CLPro). Beginning with inactive fragment hits, the application of rational linker design enabled the generation of reversible covalent inhibitors exhibiting low micromolar potency. The study details some general limitations and best practices of
Levente Kollár, Levente M. Mihalovits, Dávid Bajusz, Damijan Knez, József Simon, Blake H. Balcomb, Daren Fearon, Stanislav Gobec, György M. Keserű   +8 more
wiley   +1 more source

A Functional NSP4 Enterotoxin Peptide Secreted from Rotavirus-Infected Cells [PDF]

Journal of Virology, 2000
ABSTRACT Previous studies have shown that the nonstructural glycoprotein NSP4 plays a role in rotavirus pathogenesis by functioning as an enterotoxin. One prediction of the mechanism of action of this enterotoxin was that it is secreted from virus-infected cells.
M, Zhang, C Q, Zeng, A P, Morris, M K, Estes   +3 more
openaire   +2 more sources