Results 71 to 80 of about 332 (132)

A Cross‐Sectional Study Shows Emergence of the Delta, 19B, 20A, 20B, 19A, and Omicron Variants of SARS‐CoV‐2 in Burkina Faso: A Conundrum Within a Conundrum

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Context and Objective SARS‐CoV‐2 is an RNA virus that emerged in Wuhan, China. Adaptive mutations in its genome can influence the virus's pathogenicity, enhance its ability to evade the host immune system, and complicate vaccine development. This study aimed to identify the circulating SARS‐CoV‐2 variants in Burkina Faso and trace their origin.
Tatiana Doriane Lallogo, Lassina Traore, Ezeckiel B. TIBIRI, P. Abel Sorgho, Prosper Bado, T. Edwige Yelemkoure, Pakyendou E. Name, Valérie J. T. E. Bazie, Fidèle Tiendrebeogo, H. Karim Sombie, Abdoul Karim Ouattara, Serge Théophile Soubeiga, Abdou Azaque Zoure, Albert Théophane Yonli, Brice Bicaba, Rakissida Alfred Ouedraogo, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Assita LAMIEN/SANOU, Olga M. Lompo, Jacques Simpore   +20 more
wiley   +1 more source

Activation of calcium/calmodulin-dependent kinase II following bovine rotavirus enterotoxin NSP4 expression [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of
Hadi Razavinikoo, Hoorieh Soleimanjahi, Gholamreza Haqshenas, Taravat Bamdad, Ali Ali Teimoori, Zahra Goodarzi   +5 more
doaj  

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba, Laura Hurtado‐Navarro, Diego Angosto‐Bazarra, Alberto Baroja‐Mazo, Pablo Pelegrin   +4 more
wiley   +1 more source

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription

Journal of Virology
Coronavirus replication is understood to occur within double membrane vesicles (DMVs) that arise during viral infection. Prior work has determined that these DMVs have characteristic pores formed from the non-structural viral proteins nsp3 and nsp4 ...
Jason K. Perry, Samuel Itskanov, John P. Bilello, Eric B. Lansdon   +3 more
doaj   +1 more source

Whole‐Genome Characterization of Rare Artiodactyl‐Like G10P [14] and G8P [14] Rotavirus A Strains Detected in Pediatric Gastroenteritis Cases in Hokkaido Prefecture, Japan

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT Rotavirus alphagastroenteritidis (RVA) is the leading cause of acute gastroenteritis in young children worldwide, as well as in a wide range of animal species. In 2020 and 2022, we identified three unusual RVA strains in pediatric gastroenteritis patients in Hokkaido Prefecture, Japan, using next‐generation sequencing: one G10P[14] strain ...
Akira Takebayashi, Yuya Fukuda, Yoshiki Fujii, Hiroshi Nihira, Minako Kihara, Yoshimasa Kudou, Shuhei Adachi, Noritaka Shintani, Takeshi Tsugawa   +8 more
wiley   +1 more source

Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production.

PLoS Pathogens
Alphaviruses encode an error-prone RNA-dependent RNA polymerase (RdRp), nsP4, required for genome synthesis, yet how the RdRp functions in the complete alphavirus life cycle is not well-defined.
Marie-France Martin, Boris Bonaventure, Nia E McCray, Olve B Peersen, Kathryn Rozen-Gagnon, Kenneth A Stapleford   +5 more
doaj   +1 more source

VPS33A and VPS18 orchestrate porcine epidemic diarrhea virus replication by modulating autophagic flux

Virulence
Completion of autophagy through autophagosome-lysosome fusion represents a critical regulatory checkpoint that is frequently manipulated during viral infection, however, how coronaviruses exploit this terminal step remains incompletely understood ...
Liang Guo, Jin Li, Zhuolin Hao, Kexin Wang, Yikai Shi, Fei Gao, Xuguang Du, Sen Wu   +7 more
doaj   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

Genetic variation in NSP4 of type 1 porcine reproductive and respiratory syndrome virus in China

BMC Veterinary Research
Background Porcine reproductive and respiratory syndrome virus (PRRSV) is characterized by a high mutation rate. Although research has largely focused on PRRSV-2, the detection rate of PRRSV-1 in China is increasing.
Huiyang Sha, Xiaolin Lan, Zhiyu Yang, Chen Lv, Hang Zhang, Qin Luo, Yajie Zheng, Gan Li, Weili Kong, Liangzong Huang, Jun Ma, Mengmeng Zhao   +11 more
doaj   +1 more source

Critical role of cytochrome c1 and its cleavage in porcine reproductive and respiratory syndrome virus nonstructural protein 4-induced cell apoptosis via interaction with nsp4

Journal of Integrative Agriculture, 2017
Porcine reproductive and respiratory syndrome virus (PRRSV) actively induces cell apoptosis both in vitro and in vivo, which can contribute critically to viral pathogenesis.
Feng ZHANG, Peng GAO, Xin-na GE, Lei ZHOU, Xin GUO, Han-chun YANG   +5 more
doaj   +1 more source