Results 91 to 100 of about 332 (132)

Group A Rotavirus NSP4 is Under Negative Selective Pressure

, 2014
Rotavirus (RV) is the major etiologic agent of severe infantile gastroenteritis; its genome has 11 segments of double stranded RNA, encoding 12 proteins. The non-structural protein 4 (NSP4) encoded by segment 10 is multifunctional. The aim of this study is to analyze the selective pressure driving the NSP4 of RV, through the ratio of non-synonymous ...
Lima, Jackson Cordeiro, Bandiera-Paiva, Paulo   +1 more
openaire   +2 more sources

Establishment of an indirect ELISA detection method for porcine reproductive and respiratory syndrome virus NSP4

Frontiers in Microbiology
The non-structural protein 4 (NSP4) of porcine reproductive and respiratory syndrome virus (PRRSV) is equipped with 3C-like serine protease (3CLSP) activity, influencing crucial aspects such as virus replication, host IFN-β suppression, host cell ...
Mengmeng Zhao, Chen Lv, Jiankun Pang, Zhiyu Yang, Huiyang Sha   +4 more
doaj   +1 more source

Construction of an artificial recombinant bicistronic plasmid DNA vaccine against porcine rotavirus

Onderstepoort Journal of Veterinary Research, 2013
The attenuated Salmonella typhimurium χ4550 strain was used to harbour a reconstructed bicistronic DNA vaccine against porcine rotavirus, which carried the rotavirus nonstructural protein 4 (NSP4) and VP7 genes simultaneously. Using a balanced lethal
Tingting Cui, Jun Xiong, Yongzhi Wang, Xintian Wen, Xiaobo Huang, Yong Huang, Xiaoping Ma, Zhongkai Hu, Qin Zhao, Sanjie Cao   +9 more
doaj  

Inhibition of Semliki Forest virus replication with long double-stranded RNA in Aedes albopictus cells

Virus Research
Arthropod-borne viruses represent an increasing threat to the global health system, requiring the development of novel and sustainable control strategies to reduce the risk of arboviral infections.
Alejandra Centurión, Bodunrin Omokungbe, Sabrina Stiehler, Andreas Vilcinskas, Kornelia Hardes   +4 more
doaj   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Co-administration of rotavirus nanospheres VP6 and NSP4 proteins enhanced the anti-NSP4 humoral responses in immunized mice

Microbial Pathogenesis, 2022
Inconveniences associated with the efficacy and safety of the World Health Organization (WHO) approved/prequalified live attenuated rotavirus (RV) vaccines, sounded for finding alternative non-replicating modals and proper RV antigens (Ags). Herein, we report the development of a RV candidate vaccine based on the combination of RV VP6 nanospheres (S ...
Zabihollah Shoja, Somayeh Jalilvand, Maryam Mashhadi Abolghasem Shirazi   +2 more
exaly   +3 more sources

NSP4 antibody levels in rotavirus gastroenteritis patients with seizures

European Journal of Paediatric Neurology, 2017
Rotavirus nonstructural protein 4 (NSP4) has been suggested as a pathogen of rotavirus-associated seizures. We investigated pre-existing serum antibodies against NSP4 and VP6 (the most highly immunogenic rotavirus protein) in patients with rotavirus gastroenteritis and its correlation with the occurrence of seizures.With an enzyme-linked immunosorbent ...
Hee-Shang Youn, Jung Sook Yeom
exaly   +3 more sources

The authentic sequence of rotavirus SA11 nonstructural protein NSP4

Virus Research, 2000
Recent studies demonstrate that the rotavirus nonstructural protein NSP4 functions as an enterotoxin and plays an important role in viral pathogenesis. Previous in vitro studies of NSP4 have used a cDNA clone of gene 10 derived from the prototypic rotavirus strain, SA11. We recently compared the sequence of the commonly used NSP4 cDNA with the sequence
Peng Tian
exaly   +3 more sources

Species specificity and interspecies relatedness of NSP4 genetic groups by comparative NSP4 sequence analyses of animal rotaviruses

Archives of Virology, 2000
Previous sequence analyses of the rotavirus nonstructural NSP4 from human and some animal rotavirus strains revealed the presence of three distinct NSP4 alleles or genetic groups. To examine the species of origin relatedness and diversity of NSP4, the nucleotide and deduced amino acid sequences of the gene encoding the NSP4 from 15 animal rotavirus ...
M, Ciarlet, F, Liprandi, M E, Conner, M K, Estes   +3 more
openaire   +2 more sources

New tetrameric forms of the rotavirus NSP4 with antiparallel helices

Archives of Virology, 2018
Rotavirus nonstructural protein 4, the first viral enterotoxin to be identified, is a multidomain, multifunctional glycoprotein. Earlier, we reported a Ca2+-bound coiled-coil tetrameric structure of the diarrhea-inducing region of NSP4 from the rotavirus strains SA11 and I321 and a Ca2+-free pentameric structure from the rotavirus strain ST3, all with ...
Sushant, Kumar, Raghavendra, Ramappa, Kiranmayee, Pamidimukkala, C D, Rao, K, Suguna   +4 more
openaire   +2 more sources

Comparison of NSP4 protein between group A and B human rotaviruses: detection of novel diarrhea-causing sequences in group B NSP4

Archives of Virology, 2005
The human group B rotavirus is a causative agent of severe adult diarrhea. In this study, we analyzed the NSP4 structure of a group B rotavirus strain, CAL-1, and determined whether enterotoxin activity was present in CAL-1 NSP4. CAL-1 NSP4 was comprised of 219 amino acids which was longer than group A and C rotavirus NSP4, and the primary structures ...
M, Ishino, K, Mise, H, Takemura, M U, Ahmed, M M, Alam, T N, Naik, N, Kobayashi   +6 more
openaire   +2 more sources