Results 111 to 120 of about 332 (132)

Perspectives and potential roles for the newly discovered NSP4 in the immune system

Expert Review of Clinical Immunology, 2012
Approximately 70% of human white blood cells are neutrophils that are short-lived, but are highly efficient killers and eaters of invading microbes.
Perera, N., Jenne, D.
openaire   +3 more sources

Structure of the extended diarrhea-inducing domain of rotavirus enterotoxigenic protein NSP4

Archives of Virology, 2007
Rotavirus nonstructural protein 4 (NSP4) is a multidomainal and multifunctional protein and is recognized as the first virus-encoded enterotoxin. Extensive efforts to crystallize the complete cytoplasmic tail (CT), which exhibits all the known biological functions, have been unsuccessful, and to date, the structure of only a synthetic peptide ...
Deepa, R, Rao, Durga C, Suguna, K
openaire   +2 more sources

Rotavirus NSP4: A Multifunctional Viral Enterotoxin

Viral Immunology, 2005
Judith M, Ball, Deanne M, Mitchell, Thomas F, Gibbons, Rebecca D, Parr   +3 more
openaire   +2 more sources

NSP4 promotes replication of porcine reproductive and respiratory syndrome virus-2

Veterinary Microbiology
Porcine reproductive and respiratory syndrome (PRRS) is one of the most detrimental contagious swine ailments worldwide. Currently, no effective drugs are available for its treatment. Targeting the structural and non-structural proteins (NSP) of the type 2 PRRS virus (PRRSV-2) with small interfering RNA (siRNA) is an effective approach to inhibit PRRSV
Hang, Zhang, Gan, Li, Yajie, Zheng, Qin, Luo, Huiyang, Sha, Wenchao, Sun, Mengmeng, Zhao   +6 more
openaire   +2 more sources

The NSP4 T492I mutation increases SARS-CoV-2 infectivity by altering non-structural protein cleavage

Cell Host and Microbe, 2023
Weiwei Xue, Zhenglin Zhu, Haibo Wu
exaly  

Molecular characterization of the NSP4 gene of human group A rotavirus strains circulating in Tunisia from 2006 to 2008

Infection, Genetics and Evolution, 2012
Anissa Chouikha, Imène Fodha, Marc Van Ranst   +2 more
exaly  

Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro

Virology, 2009
Brian R Wasik, Richard Hardy, Janet L Smith   +2 more
exaly  

Aspartic acid at residue 185 modulates the capacity of HP-PRRSV nsp4 to antagonize IFN-I expression

Virology, 2020
Wen-Hai Feng, Ziding Zhang, Zhongzhou Chen   +2 more
exaly  

The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production

Proceedings of the National Academy of Sciences of the United States of America, 1997
Mary Estes, Judith M Ball, Estes Mary K
exaly  

A new pentameric structure of rotavirus NSP4 revealed by molecular replacement

Acta Crystallographica Section D: Biological Crystallography, 2012
Randy J Read, Jeyaraman Jeyakanthan, Suguna K   +2 more
exaly