Results 101 to 110 of about 332 (132)

A new pentameric structure of rotavirus NSP4 revealed by molecular replacement

Acta Crystallographica Section D Biological Crystallography, 2011
The region spanning residues 95-146 of the rotavirus nonstructural protein NSP4 from the asymptomatic human strain ST3 has been purified and crystallized and diffraction data have been collected to a resolution of 2.6 Å. Several attempts to solve the structure by the molecular-replacement method using the available tetrameric structures of this domain ...
Chacko, Anita R, Jeyakanthan, J, Ueno, G, Sekar, K, Rao, Durga C, Dodson, Eleanor J, Suguna, Kaza, Read, Randy J   +7 more
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VP7, VP4, and NSP4 genes of species a rotaviruses isolated from sewage in Nigeria, 2014/2015: partial sequence characterization and biophysical analysis of NSP4 (enterotoxin)

Virus Genes, 2022
Species A rotavirus are an important cause of childhood gastroenteritis, and the main contributor to its pathogenicity is the enterotoxin (NSP4) protein. Some biophysical properties of partial NSP4 genes of RVAs isolated from sewage in Nigeria during 2014/2015 were investigated. Samples were typed by RT-PCR and Sanger sequencing of partial VP4, VP7 and
Babatunde O. Motayo, Adedayo O. Faneye, Johnson A. Adeniji   +2 more
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Adaptive evolution of rotavirus VP7 and NSP4 genes in different species

Computational Biology and Chemistry, 2009
Rotavirus is recognized as the major enteric pathogen associated with high burden of worldwide epidemic diarrhea disease in human and animals. Its outer capsid structural protein VP7 elicits the production of distinct neutralizing antibodies in the host and also determines the serotype of the virus strain.
Xiaofeng Song, Yan Hao
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TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication

Journal of Virology, 2022
Alphaviruses are positive-stranded RNA viruses with more than 30 members. Infection with Old World alphaviruses, which comprise some important human pathogens such as chikungunya virus and Ross River virus, rarely results in fatal diseases but can lead to high morbidity in humans.
Feixiang Yan, Wei Yang, Xinlu Wang, Guangxia Gao   +3 more
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Novel NSP4 genotype in a camel G10P[15] rotavirus strain

Acta Microbiologica et Immunologica Hungarica, 2012
In this study a Kuwaiti camel rotavirus strain, RVA/Camel-wt/KUW/s21/2010/G10P[15], is characterized by sequencing and phylogenetic analysis. The strain had multiple genes with high nucleotide sequence similarities to ovine and bovine strains (VP2, ≤ 96%; NSP2 and NSP5, ≤ 97%, NSP3, ≤ 94%), or, to porcine strains (VP1, ≤ 89%).
Papp H, Al Mutairi LZ, Chehadeh W, Farkas SL, Lengyel G, Jakab F, Szűcs G, Banyai K., MARTELLA, Vito   +8 more
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Rotaviruses: Extraction and Isolation of RNA, Reassortant Strains, and NSP4 Protein

Current Protocols in Microbiology, 2015
AbstractRotavirus (RV) contains 11 double‐stranded RNA segments that encode for twelve structural and nonstructural proteins. The separation and isolation of viral RNA is a necessary precursor for many experimental techniques and can be useful for rapid RV RNA typing and sequencing of different rotavirus strains.
Krystle A, Yakshe, Zachary D, Franklin, Judith M, Ball   +2 more
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Group C rotavirus NSP4 induces diarrhea in neonatal mice

Archives of Virology, 2001
Nonstructural glycoprotein NSP4 of group A rotavirus induces diarrhea in neonatal mice by functioning as an enterotoxin. Previously, our laboratory reported that the structural features of group A and group C rotavirus NSP4 proteins are well conserved despite a lack of sequence homology between group A and group C rotavirus NSP4 proteins [Horie Y, et ...
S, Sasaki, Y, Horie, T, Nakagomi, M, Oseto, O, Nakagomi   +4 more
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Uncovering the evolutionary tail of GZMM: An NSP4 related protease

2022
Abstract Serine proteases are the most predominant class performing a number of activities in organisms. Undergoing several mutations in their sequence over a span of a billion years yet S1 chymotrypsin/trypsin family has maintained a common fold.
Ahmer Bin Hafeez, Jamshaid Ahmad
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Humoral immune response to rotavirus NSP4 enterotoxin in Spanish children

Journal of Medical Virology, 2005
The rotavirus non-structural protein 4 (NSP4) has been shown to play a crucial role in rotavirus-induced diarrhea, acting as a viral enterotoxin. It has also been demonstrated that antibody to NSP4 can reduce the severity of rotavirus-induced diarrhea in newborn mice.
Rodríguez Díaz, Jesús, Montava, Rebeca, García Díaz, Ana, Buesa, Javier   +3 more
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[Analysis on molecular characteristic of VP7 and NSP4].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2010
To explore the molecular characteristics and molecular variation of human rotavirus (HRV) strains and to understand the relationship between clinical characteristics and epidemiology of different HRV-VP7 and NSP4.Double-strand RNA of rotavirus extracted from stool samples was used as the template for reverse transcription of gene VP7, which was ...
Yong-Kun, Huang, Qin, Qi, Zong-Liu, Hou, Hai-Lin, Li, Ge-Sheng, Wen, Wei, Pang, Li-Fang, Zhou   +6 more
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