Results 71 to 80 of about 14,170 (209)
Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]
SLAS Discovery, 2020 ABSTRACTSmall molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus’ ability to evade cellular detection. A high-throughput assay based on differential scanning fluorimetry (DSF) was
Rajdeep S. Virdi +6 more
openaire +5 more sources
Emerging Microbes and Infections, 2021 The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication.
Mehdi Moustaqil +12 more
doaj +1 more source
Analysis of genetic diversity and molecular evolution of human group B rotaviruses based on whole genome segments [PDF]
, 2010 Group B rotavirus (GBR) is a rare enteric pathogen that causes severe diarrhoea, primarily in adults. Nearly full-length sequences of all 11 RNA segments were determined for human GBRs detected recently in India (IDH-084 in 2007, IC-008 in 2008 ...
Ahmed +37 more
core +1 more source
Advanced Science, Volume 13, Issue 24, 27 April 2026.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
The Chikungunya virus nsP3 macro domain inhibits activation of the NF-κB pathway [PDF]
Viruses, 2019 AbstractThe role of the chikungunya virus (CHIKV) non-structural protein 3 (nsP3) in the virus lifecycle is poorly understood. The protein comprises 3 domains. The N-terminus is a macro domain, biochemically characterised to bind both RNA and ADP-ribose, and to possess ADP-ribosyl hydrolase activity – an enzymatic activity that removes ADP-ribose from ...
Roberts, Grace C. +2 more
openaire +4 more sources
READDI protocol: Crystallisation of CHIKV nsP3 macrodomain v1
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months or even years. Millions of people have been infected with CHIKV, mostly in low- and middle-income countries, and the virus continues to spread into new areas due to the geographical expansion of its mosquito hosts.
Jasmin Aschenbrenner +4 more
openaire +2 more sources
Molecules, 2020 In recent years, intrinsically disordered proteins (IDPs) and disordered domains have attracted great attention. Many of them contain linear motifs that mediate interactions with other factors during formation of multicomponent protein complexes.
Peter Agback +4 more
doaj +1 more source
High-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencing. [PDF]
PLoS Pathogens, 2010 We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally important regions of the Venezuelan ...
Brett F Beitzel +3 more
doaj +1 more source
Fostering Equitable Foreclosure Recovery [PDF]
, 2012 This report provides essential information to inform policy discussions about foreclosure recovery. It presents information about the foreclosure crisis and its consequences, describes the federal program created to help communities recover from the ...
Jennifer Tran +2 more
core
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT Severe COVID‐19 involves hyperinflammation and multiorgan pathology, but consistent gene signatures remain elusive. We aimed to identify consensus transcriptomic signatures and molecular mechanisms in severe COVID‐19. We performed an integrative analysis of 39 studies spanning 11 tissue types, 1551 bulk RNA‐seq samples, and over 2 million ...
Jonathan Peña Avila +31 more
wiley +1 more source