Results 71 to 80 of about 12,322 (192)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

SARS-CoV-2-encoded miR-nsp3-3p promotes pulmonary fibrosis by inhibiting expression of ALCAM

Virologica Sinica
microRNAs (miRNAs) derived from viruses, have been detected in body fluids and are known to regulate the expression of host genes. Recent evidence indicates that SARS-CoV-2-encoded miRNAs could contribute to pulmonary disease.
Yang Yang, Qiu-Yue Wu, Xueyan Liu, Hongjian Zhou, Jian-Zhen Lei, Lan Luo, Xin-Yi Xia   +6 more
semanticscholar   +1 more source

The importance of the 3' end and NSP3 origin for rotavirus-like reporter mRNA translation.

, 2016
A: Cytoplasmic expression of NSP3-RF and NSP3-SA in BSRT7 cells. Lysate from BSRT7 cells transfected for 24 h with expression vectors encoding NSP3 from the RF (NSP3-RF) or SA11 (NSP3-SA) RVA strains or no NSP3 (NSP3-KO). The lysates were analyzed (using
Cécile Laroche (842228), Didier Poncet (371932), Mariela Duarte (842231), Hilma Carolina Baron (842227), Matthieu Gratia (842225), Stéphane Pyronnet (842230), Patrice Vende (842226), Annie Charpilienne (371930), Emeline Sarot (842229)   +8 more
core   +1 more source

Recognition of the Rotavirus mRNA 3′ Consensus by an Asymmetric NSP3 Homodimer [PDF]

, 2002
Rotaviruses, the cause of life-threatening diarrhea in humans and cattle, utilize a functional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for translation of viral mRNAs.
Groft, Caroline M., Rajashankar, K.R., Deo, Rahul C., Burley, Stephen K.   +3 more
core   +1 more source

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

Cell Reports
Summary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie, Jie Cao, Xinya Yang, Ruzhu Hou, Suhong Qian, Guojie Wang, Shiyu Deng, Luo-Na Lin, Yue Liu, Peiguo Yang, Rong Zhang, Qiang Ding, Peng Sun, Wenchun Fan   +13 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Exploration of Nirmatrelvir Derivatives as Optimized SARS‐CoV‐2 Antivirals

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Structure‐guided optimization of nirmatrelvir identifies aldehyde and dichloroacetamide warheads and a potency‐enhancing S4 thioamide. Crystal structures reveal an S2 rearrangement extending toward Cys44, suggesting a new covalent‐design opportunity.
Yugendar R. Alugubelli, Veerabhadra R. Vulupala, Kai S. Yang, Kaustav Khatua, Lauren R. Blankenship, Sathish Kumar, Demonta Coleman, Xuejiao Guo, Zhi Zachery Geng, Chia‐Chuan D. Cho, Banumathi Sankaran, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu   +13 more
wiley   +1 more source

Antiviral Activitiy of Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin and Cyclocurcumin compounds of Curcuma longa against NSP3 on SARS-CoV-2

Indonesian Journal of Cancer Chemoprevention, 2023
SARS-CoV-2 genome encodes two large polyproteins (pp), pp1a and pp1ab which are cleaved and transformed into a mature form by a protease, non-structural protein 3 (NSP3). NSP3 is encoded by open reading frame (ORF) 1a/b. Curcuma longa (C.
Rizka Nurul Hidayah, Belia Bima Nafisa, Miftah Arifin, Dewi Santosaningsih, R. Muti'ah   +4 more
semanticscholar   +1 more source

Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane Pairing

Viruses, 2018
Positive-strand RNA viruses, such as coronaviruses, induce cellular membrane rearrangements during replication to form replication organelles allowing for efficient viral RNA synthesis.
Nicole Doyle, Benjamin W. Neuman, Jennifer Simpson, Philippa C. Hawes, Judith Mantell, Paul Verkade, Hasan Alrashedi, Helena J. Maier   +7 more
doaj   +1 more source