Results 51 to 60 of about 407 (85)

The transmembrane segments of SARS-CoV-2 nsp3 govern viral intracellular trafficking

Cell & Bioscience
After entry, coronaviruses deliver their genomic RNA to the ER-Golgi intermediate compartment to build replication organelles, yet how the RNA first contacts membranes is unclear.
Manqi Cao, Lang Qin, Huaan Zhang, Wenhao Wang, Qiao Ling, Jiaxin Zhuang, Fushi Zhang, Zhihui Zhang, Weiyi Huang, Huijie Li, Yushan Xue, Jiayi Yang, Jiayue Liu, Liubing Du, Deyin Guo, Ji-An Pan, Xiaoxue Peng   +16 more
doaj   +1 more source

Recent Increase in Rotavirus Gastroenteritis After Five Years of Low Activity in Hokkaido Prefecture, Japan, Associated With Equine‐Like G3P[8] and G8P[8] Strains, 2025

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Rotavirus gastroenteritis decreased substantially worldwide during the COVID‐19 pandemic, and activity remained minimal in Hokkaido Prefecture, Japan, for 5 years after 2020. Hospital‐based surveillance in Hokkaido since July 2019 identified the first resurgence of rotavirus gastroenteritis in 2025.
Yuya Fukuda, Yoshiki Fujii, Atsuo Togashi, Tomohiro Nawa, Satoshi Nakamura, Ryoma Kimura, Jun Kunizaki, Yuuki Ando, Kouhei Nishino, Toshitaka Kizawa, Dai Yamamoto, Yoshiyuki Iizuka, Yuta Sasaoka, Masayoshi Kikuchi, Kousuke Nishikawa, Kazushige Nagai, Hirofumi Asakura, Shoya Shimokawa, Hiroyuki Kabutoya, Seiji Kobayashi, Takeshi Tsugawa   +20 more
wiley   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Cryo-EM reveals a double oligomeric ring scaffold of the CHIKV nsP3 peptide in complex with the NTF2L domain of host G3BP1

mBio
Chikungunya virus (CHIKV) poses a severe threat to global public health. The interaction between CHIKV nsP3 and host G3BP1 is critical for viral replication. However, the exact structural mechanism of the nsP3–G3BP1 interaction is scarce. Here, we report
Yuanzhi Liu, Jie Wang, Yinze Han, Xiaoyan Xia, Rui Zeng, Xinyu Fan, Bo Zhang, Kaituo Wang, Jian Lei   +8 more
doaj   +1 more source

Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune system

Virology Journal, 2019
Background Transmissible gastroenteritis virus (TGEV), a member of the family Coronaviridae, causes lethal watery diarrhea in piglets. Previous studies have revealed that the coronaviruses develop various strategies to evade the host innate immunity ...
Yanan Wang, Aoying Sun, Yu Sun, Sijia Zhang, Tian Xia, Tiantian Guo, Zhenye Hao, Li Sun, Yanping Jiang, Xinyuan Qiao, Wen Cui, Lijie Tang, Yigang Xu, Yijing Li, Li Wang   +14 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Comparative Interactome Profiling of Nonstructural Protein 3 Across SARS-CoV-2 Variants Emerged During the COVID-19 Pandemic

Viruses
SARS-CoV-2 virus and its variants remain a global health threat, due to their capacity for rapid evolution. Variants throughout the COVID-19 pandemic exhibited variations in virulence, impacting vaccine protection and disease severity.
Valeria Garcia Lopez, Lars Plate
doaj   +1 more source

Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells

npj Viruses
Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2).
Tessy A. H. Hick, Taja Zotler, Davita Bosveld, Corinne Geertsema, Monique M. van Oers, Gorben P. Pijlman   +5 more
doaj   +1 more source

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription

Journal of Virology
Coronavirus replication is understood to occur within double membrane vesicles (DMVs) that arise during viral infection. Prior work has determined that these DMVs have characteristic pores formed from the non-structural viral proteins nsp3 and nsp4 ...
Jason K. Perry, Samuel Itskanov, John P. Bilello, Eric B. Lansdon   +3 more
doaj   +1 more source

The DMV pore-forming TM2–Y region of SARS-CoV-2 nsp3 exhibits structural conservation beyond the coronavirus family

Journal of Virology
Positive-strand RNA viruses remodel host intracellular membranes to form replication organelles in the cytoplasm. SARS-CoV-2 and other coronaviruses, members of the Nidovirales order, replicate within double-membrane vesicles (DMVs) derived from the ...
Alexandra Pozhidaeva, Jeffrey C. Hoch, Yulia Pustovalova   +2 more
doaj   +1 more source