Results 51 to 60 of about 12,322 (192)

Nsp3 model docked into cryo-ET density

, 2022
Nsp3 model docked into cryo-ET density (EMD 11514, from Wolff G, et al, Science    369:1395–1398. doi:10.1126/SCIENCE.ABD3629. Generated by Peter Stogios, University of Toronto.
Peter Stogios (659463)
core   +1 more source

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis

Journal of Medical Virology, 2020
Last December 2019, a new virus, named novel Coronavirus (COVID‐2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID‐2019 pathogenesis. The Open Reading Frame 1ab (ORF1ab) of
S. Angeletti, D. Benvenuto, M. Bianchi, Marta Giovanetti, S. Pascarella, M. Ciccozzi   +5 more
semanticscholar   +1 more source

Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci [PDF]

, 2012
Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP).
Pijlman, G.P., Domeradzka, N.E., Baggen, J., Geertsema, C., Fros, J.J., Vlak, J.M., Flipse, J.   +6 more
core   +1 more source

Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy

Pharmaceuticals, 2022
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges (NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared.
Md. Khalid Anwer, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Muzaffar Iqbal, Vinay Kumar   +4 more
doaj   +1 more source

Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins

Journal of Biomolecular Structure and Dynamics, 2023
: The COVID-19 pandemic caused by SARS-CoV-2 virus has created a global damage and has exposed the vulnerable side of scientific research towards novel diseases.
Zeeshan Ali, J. V. Cardoza, Srijita Basak, Utkarsh Narsaria, Vijay Singh, Samuel Paul Isaac, T. França, S. LaPlante, Sudhan S George   +8 more
semanticscholar   +1 more source

Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound naringenin as a promising drug candidate against COVID-19

Journal of Molecular Structure, 2023
The prevalence of SARS-CoV-2-induced respiratory infections is now a major challenge worldwide. There is currently no specific antiviral drug to prevent or treat this disease.
Elahe Aleebrahim-Dehkordi, Hamed Ghoshouni, Pooneh Koochaki, Mohsen Esmaili-Dehkordi, Elham Aleebrahim, Fatemeh Chichagi, Ali Jafari, S. Hanaei, Ehsan Heidari-Soureshjani, N. Rezaei   +9 more
semanticscholar   +1 more source

Proteomic Analysis of CHIKV-nsP3 Host Interactions in Liver Cells Identifies Novel Interacting Partners

International Journal of Molecular Sciences
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has re-emerged, causing widespread outbreaks and a significant clinical burden. Despite advances in virology, the molecular mechanisms governing CHIKV’s interaction with host cells remain poorly ...
Nimisha Mishra, Yash Chaudhary, Sakshi Chaudhary, A. Singh, Priyanshu Srivastava, Sujatha Sunil   +5 more
semanticscholar   +1 more source

WHOLE GENOME SEQUENCE OF SARS-COV-2 FROM COVID-19 ACQUIRED HEMOPHILIA PATIENT

International Journal of Infectious Diseases, 2023
Intro: Acquired hemophilia is an atypical pathology of SARS-CoV-2 infection, which could be variant associated. Here, we share a sequence of the SARS-CoV-2 genome from patient with COVID-19 acquired haemophilia.
U.A. Zainulabid, A. Aslam, M. Hussain, I. Ibrahim, P. Periyasamy, N. Kamarudin, H.F. Ahmad   +6 more
doaj   +1 more source

SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12

Journal of Cell Biology
The NSP3/4/12 axis in β-coronaviruses orchestrates the formation of double-membrane vesicles (DMVs) and the assembly of replication organelles by utilizing distinct domains of NSP3 and NSP4.
Jin-Ping Yang, Buyun Tian, Pei Wang, Rongrong Chen, Ke Xiao, Xubing Long, Xinyue Zheng, Yun Zhu, Fei Sun, Yongxia Shi, Yaming Jiu, Wei Ji, Yanhong Xue, Tao Xu, Zonghong Li   +14 more
semanticscholar   +1 more source

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2

ACS Omega, 2023
The human Betacoronavirus SARS-CoV-2 is a novel pathogen claiming millions of lives and causing a global pandemic that has disrupted international healthcare systems, economies, and communities.
Abdul‐Rahman Azizogli, Varun Pai, Francesco Coppola, Roya Jafari, Joseph Dodd-o, R. Harish, Bhavani Balasubramanian, Jatin Kashyap, Amanda M. Acevedo-Jake, P. Kŕal, Vivek A Kumar   +10 more
semanticscholar   +1 more source