Results 31 to 40 of about 407 (85)

Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane Pairing

Viruses, 2018
Positive-strand RNA viruses, such as coronaviruses, induce cellular membrane rearrangements during replication to form replication organelles allowing for efficient viral RNA synthesis.
Nicole Doyle, Benjamin W. Neuman, Jennifer Simpson, Philippa C. Hawes, Judith Mantell, Paul Verkade, Hasan Alrashedi, Helena J. Maier   +7 more
doaj   +1 more source

Exploration of Nirmatrelvir Derivatives as Optimized SARS‐CoV‐2 Antivirals

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Structure‐guided optimization of nirmatrelvir identifies aldehyde and dichloroacetamide warheads and a potency‐enhancing S4 thioamide. Crystal structures reveal an S2 rearrangement extending toward Cys44, suggesting a new covalent‐design opportunity.
Yugendar R. Alugubelli, Veerabhadra R. Vulupala, Kai S. Yang, Kaustav Khatua, Lauren R. Blankenship, Sathish Kumar, Demonta Coleman, Xuejiao Guo, Zhi Zachery Geng, Chia‐Chuan D. Cho, Banumathi Sankaran, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu   +13 more
wiley   +1 more source

Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

Nature Communications
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L. Thienel, Beate M. Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera   +16 more
doaj   +1 more source

Structural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5’ UTR of the viral genome

Microbiology Spectrum
Non-structural protein 3 (Nsp3) is the largest open reading frame encoded in the SARS-CoV-2 genome, essential for the formation of double-membrane vesicles (DMV) wherein viral RNA replication occurs.
Sofia Lemak, Tatiana Skarina, Deepak T. Patel, Peter J. Stogios, Alexei Savchenko   +4 more
doaj   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, Volume 13, Issue 45, 13 August 2026.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Two Lineages of DS‐1‐Like G3P[8] Human Rotaviruses in Sabah, Malaysia: Genetic Diversity and Evidence of Reassortment

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Group A rotavirus (RVA) genotype G3P[8] strains typically carry a Wa‐like genomic backbone, but DS‐1‐like G3P[8] reassortants have disseminated globally since 2013. In Sabah, Malaysia, surveillance in 2018–2019 identified frequent G3P[8] strains with a short RNA electropherotype, consistent with DS‐1‐like backbones.
Yuki Akari, Lia Natasha Amit, Jecelyn Leaslie John, Daisuke Mori, Abraham Zefong Chin, Andau Konodan Mosiun, Saori Fukuda, Maurine Mumo Mutua, Ibuki Sato, Yoshimasa Maeno, Kamruddin Ahmed, Satoshi Komoto   +11 more
wiley   +1 more source

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Viruses, 2021
Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus and a category B select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat VEEV exposure and resultant disease manifestations. The C-terminus of the VEEV
Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan   +5 more
doaj   +1 more source

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy

Scientific Reports, 2017
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...
Roland Remenyi, Grace C. Roberts, Carsten Zothner, Andres Merits, Mark Harris   +4 more
doaj   +1 more source

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Cell & Bioscience, 2021
Background Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex.
Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin, Liubing Du, Yunyun Jin, Liu Cao, Jingquan Tan, Xing-Ding Zhang, Deyin Guo, Ji-An Pan, Xiaoxue Peng   +12 more
doaj   +1 more source

SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue, Alejandro Cornejo, Héctor Rafael Rangel   +2 more
wiley   +1 more source