Results 21 to 30 of about 14,170 (209)

Species A rotavirus NSP3 acquires its translation inhibitory function prior to stable dimer formation. [PDF]

PLoS ONE, 2017
Species A rotavirus non-structural protein 3 (NSP3) is a translational regulator that inhibits or, under some conditions, enhances host cell translation.
Hugo I Contreras-Treviño, Edgar Reyna-Rosas, Renato León-Rodríguez, Blanca H Ruiz-Ordaz, Tzvetanka D Dinkova, Ana M Cevallos, Luis Padilla-Noriega   +6 more
doaj   +1 more source

Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates

Biomedicines, 2021
The multi-domain non-structural protein 3 (NSP3) is an oncogenic molecule that has been concomitantly implicated in the progression of coronavirus infection. However, its oncological role in lung cancer and whether it plays a role in modulating the tumor
Yuan-Chieh Yeh, Bashir Lawal, Michael Hsiao, Tse-Hung Huang, Chi-Ying F. Huang   +4 more
doaj   +1 more source

Functional Analysis of nsP3 Phosphoprotein Mutants ofSindbisVirus [PDF]

Journal of Virology, 2003
ABSTRACT Alphavirus nsP3 phosphoprotein is essential for virus replication and functions initially within polyprotein P123 or P23 components of the short-lived minus-strand replicase, and upon polyprotein cleavage, mature nsP3 likely functions also in plus-strand synthesis.
Indra, Dé, Cori, Fata-Hartley, Stanley G, Sawicki, Dorothea L, Sawicki   +3 more
openaire   +2 more sources

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication. [PDF]

PLoS Pathogens, 2011
Among the four non-structural proteins of alphaviruses the function of nsP3 is the least well understood. NsP3 is a component of the viral replication complex, and composed of a conserved aminoterminal macro domain implicated in viral RNA synthesis, and ...
Maarit Neuvonen, Arunas Kazlauskas, Miika Martikainen, Ari Hinkkanen, Tero Ahola, Kalle Saksela   +5 more
doaj   +1 more source

Getah Virus in Review: An Emerging Zoonotic Arbovirus. [PDF]

Transbound Emerg Dis
Getah virus (GETV), a zoonotic virus, belongs to Togaviridae, Alphavirus. GETV leads to diarrhea in piglets and dysfunction of the reproductive system in sows, with pregnant sows potentially experiencing abortion, fetal death, or weak offspring, causing a severe impact on the livestock industry and resulting in economic losses.
Qiu Z, Zhang D, Fan Q, Hu Z, Xie H, Li N, Xiao P.   +6 more
europepmc   +2 more sources

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain [PDF]

Bioorganic & Medicinal Chemistry, 2022
AbstractA series of amino acid based7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for coronavirus replication and pathogenesis.
Lavinia M. Sherrill, Elva E. Joya, AnnMarie Walker, Anuradha Roy, Yousef M. Alhammad, Moriama Atobatele, Sarah Wazir, George Abbas, Patrick Keane, Junlin Zhuo, Anthony K.L. Leung, David K. Johnson, Lari Lehtiö, Anthony R. Fehr, Dana Ferraris   +14 more
openaire   +3 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1. [PDF]

Adv Sci (Weinh)
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Zhang Y, Liu Y, Yao Z, Lai H, Chen X, Wang Z, Bao Y, Li T, Zhou X, Chen X, Yang P.   +10 more
europepmc   +2 more sources

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes

IUCrJ, 2020
Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Lucy Stols, Michael Endres, Andrzej Joachimiak   +6 more
doaj   +1 more source

SARS-CoV-2 nucleocapsid and Nsp3 binding: an in silico study [PDF]

Archives of Microbiology, 2020
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) belongs to the single-stranded positive-sense RNA family. The virus contains a large genome that encodes four structural proteins, small envelope (E), matrix (M), nucleocapsid phosphoprotein (N), spike (S), and 16 nonstructural proteins (nsp1-16) that together, ensure replication of the virus in ...
Khan, Muhammad Tahir, Zeb, Muhammad Tariq, Ahsan, Hina, Ahmed, Abrar, Ali, Arif, Akhtar, Khalid, Malik, Shaukat Iqbal, Cui, Zhilei, Ali, Sajid, Khan, Anwar Sheed, Ahmad, Manzoor, Wei, Dong-Qing, Irfan, Muhammad   +12 more
openaire   +2 more sources

Formation of nsP3-Specific Protein Complexes during Sindbis Virus Replication [PDF]

Journal of Virology, 2006
ABSTRACTAlphaviruses are arthropod-borne viruses (arboviruses) that include a number of important human and animal pathogens. Their replication proceeds in the cytoplasm of infected cells and does not directly depend on nuclei. Alphaviruses encode only four nonstructural proteins that are required for the replication of viral genome and transcription ...
Elena, Frolova, Rodion, Gorchakov, Natalia, Garmashova, Svetlana, Atasheva, Leoncio A, Vergara, Ilya, Frolov   +5 more
openaire   +2 more sources