Results 21 to 30 of about 407 (85)

WHOLE GENOME SEQUENCE OF SARS-COV-2 FROM COVID-19 ACQUIRED HEMOPHILIA PATIENT

International Journal of Infectious Diseases, 2023
Intro: Acquired hemophilia is an atypical pathology of SARS-CoV-2 infection, which could be variant associated. Here, we share a sequence of the SARS-CoV-2 genome from patient with COVID-19 acquired haemophilia.
U.A. Zainulabid, A. Aslam, M. Hussain, I. Ibrahim, P. Periyasamy, N. Kamarudin, H.F. Ahmad   +6 more
doaj   +1 more source

Challenging the Roles of NSP3 and Untranslated Regions in Rotavirus mRNA Translation. [PDF]

PLoS ONE, 2016
Rotavirus NSP3 is a translational surrogate of the PABP-poly(A) complex for rotavirus mRNAs. To further explore the effects of NSP3 and untranslated regions (UTRs) on rotavirus mRNAs translation, we used a quantitative in vivo assay with simultaneous ...
Matthieu Gratia, Patrice Vende, Annie Charpilienne, Hilma Carolina Baron, Cécile Laroche, Emeline Sarot, Stéphane Pyronnet, Mariela Duarte, Didier Poncet   +8 more
doaj   +1 more source

Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulation for the Discovery of Novel SARS-CoV-2 NSP3 Mac1 Domain Inhibitors

Viruses, 2023
Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs).
Behnaz Yazdani, Hajar Sirous, Simone Brogi, Vincenzo Calderone   +3 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay

Journal of Virology
Alphaviruses can cause polyarthralgia and encephalitis and pose an escalating global health threat to humans and animals. They are transmitted to vertebrates mainly by infected mosquitoes, leading to host alternation that drives an evolutionary arms race
Ana Alice Pimenta-Pereira, Bailey Lubinski, Rafael Kroon Campos   +2 more
doaj   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, EarlyView.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

Cell Reports
Summary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie, Jie Cao, Xinya Yang, Ruzhu Hou, Suhong Qian, Guojie Wang, Shiyu Deng, Luo-Na Lin, Yue Liu, Peiguo Yang, Rong Zhang, Qiang Ding, Peng Sun, Wenchun Fan   +13 more
doaj   +1 more source