Results 21 to 30 of about 9,079 (162)

The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions

EMBO Reports
Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these ...
Leah K Estes, R Elias Alvarado, Fabian Coscia   +2 more
exaly   +2 more sources

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain [PDF]

Bioorganic & Medicinal Chemistry, 2022
Abstract A series of amino acid based 7H -pyrrolo[2,3- d ]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for ...
Lavinia M. Sherrill, Elva E. Joya, AnnMarie Walker, Anuradha Roy, Yousef M. Alhammad, Moriama Atobatele, Sarah Wazir, George Abbas, Patrick Keane, Junlin Zhuo, Anthony K.L. Leung, David K. Johnson, Lari Lehtiö, Anthony R. Fehr, Dana Ferraris   +14 more
openaire   +3 more sources

Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation

Microorganisms, 2023
Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication.
Shangxin Yang, Ashrit Multani, Jacob M. Garrigues, Michael S. Oh, Peera Hemarajata, Taylor Burleson, Nicole M. Green, Caspian Oliai, Pryce T. Gaynor, Omer E. Beaird, Drew J. Winston, Christopher S. Seet, Joanna M. Schaenman   +12 more
doaj   +1 more source

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis [PDF]

Journal of Medical Virology, 2020
AbstractLast December 2019, a new virus, named novel Coronavirus (COVID‐2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID‐2019 pathogenesis. The Open Reading Frame 1ab (ORF1ab) of COVID‐2019 has been analyzed to evidence the presence of mutation caused by selective ...
Silvia Angeletti, Domenico Benvenuto, Martina Bianchi, Marta Giovanetti, Stefano Pascarella, Massimo Ciccozzi   +5 more
openaire   +3 more sources

Preparation of polyclonal antibodies and subcellular localization of non-structural protein 3 encoded by feline coronavirus

浙江大学学报. 农业与生命科学版, 2023
The non-structural protein 3 (Nsp3) of coronavirus, a component of the replication and transcription complex, is one of the potentially important antiviral targets.
WANG Ziyi, JIN Zi’an, LU Chenhe, QIAO Zhi, WANG Shengwen, YAN Yan, ZHOU Jiyong, ZHENG Xiaojuan   +7 more
doaj   +1 more source

Species A rotavirus NSP3 acquires its translation inhibitory function prior to stable dimer formation. [PDF]

PLoS ONE, 2017
Species A rotavirus non-structural protein 3 (NSP3) is a translational regulator that inhibits or, under some conditions, enhances host cell translation.
Hugo I Contreras-Treviño, Edgar Reyna-Rosas, Renato León-Rodríguez, Blanca H Ruiz-Ordaz, Tzvetanka D Dinkova, Ana M Cevallos, Luis Padilla-Noriega   +6 more
doaj   +1 more source

Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates

Biomedicines, 2021
The multi-domain non-structural protein 3 (NSP3) is an oncogenic molecule that has been concomitantly implicated in the progression of coronavirus infection. However, its oncological role in lung cancer and whether it plays a role in modulating the tumor
Yuan-Chieh Yeh, Bashir Lawal, Michael Hsiao, Tse-Hung Huang, Chi-Ying F. Huang   +4 more
doaj   +1 more source

SARS-CoV-2 nucleocapsid and Nsp3 binding: an in silico study [PDF]

Archives of Microbiology, 2020
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) belongs to the single-stranded positive-sense RNA family. The virus contains a large genome that encodes four structural proteins, small envelope (E), matrix (M), nucleocapsid phosphoprotein (N), spike (S), and 16 nonstructural proteins (nsp1-16) that together, ensure replication of the virus in ...
Khan, Muhammad Tahir, Zeb, Muhammad Tariq, Ahsan, Hina, Ahmed, Abrar, Ali, Arif, Akhtar, Khalid, Malik, Shaukat Iqbal, Cui, Zhilei, Ali, Sajid, Khan, Anwar Sheed, Ahmad, Manzoor, Wei, Dong-Qing, Irfan, Muhammad   +12 more
openaire   +2 more sources

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication. [PDF]

PLoS Pathogens, 2011
Among the four non-structural proteins of alphaviruses the function of nsP3 is the least well understood. NsP3 is a component of the viral replication complex, and composed of a conserved aminoterminal macro domain implicated in viral RNA synthesis, and ...
Maarit Neuvonen, Arunas Kazlauskas, Miika Martikainen, Ari Hinkkanen, Tero Ahola, Kalle Saksela   +5 more
doaj   +1 more source

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2

ACS Omega, 2023
The human Betacoronavirus SARS-CoV-2 is a novel pathogen claiming millions of lives and causing a global pandemic that has disrupted international healthcare systems, economies, and communities. The virus is fast mutating and presenting more infectious but less lethal versions. Currently, some small-molecule therapeutics have received FDA emergency use
Abdul-Rahman Azizogli, Varun Pai, Francesco Coppola, Roya Jafari, Joseph B. Dodd-o, Rohan Harish, Bhavani Balasubramanian, Jatin Kashyap, Amanda M. Acevedo-Jake, Petr Král, Vivek A. Kumar   +10 more
openaire   +2 more sources