Results 41 to 50 of about 12,322 (192)

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

bioRxiv, 2022
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality.
Stefan Gahbauer, G. Correy, M. Schuller, Matteo P. Ferla, Y. U. Doruk, Moira M. Rachman, Taia Wu, Morgan E. Diolaiti, Siyi Wang, R. J. Neitz, D. Fearon, Dmytro S. Radchenko, Yurii S. Moroz, J. Irwin, A. Renslo, Jenny C. Taylor, J. Gestwicki, F. von Delft, A. Ashworth, I. Ahel, B. Shoichet, J. Fraser   +21 more
semanticscholar   +1 more source

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes

IUCrJ, 2020
Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Lucy Stols, Michael Endres, Andrzej Joachimiak   +6 more
doaj   +1 more source

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]

Open Biology, 2016
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte, Lifeng Liu, Marc D. Panas, Bastian Thaa, Nicole Dickson, Benjamin Götte, Adnane Achour, Gerald M. McInerney   +7 more
doaj   +1 more source

Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity.

PLoS Neglected Tropical Diseases, 2023
Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people.
Nathaniel M Byers, Paul L Burns, Olga Stuchlik, Matthew S Reed, Jeremy P Ledermann, Jan Pohl, Ann M Powers   +6 more
doaj   +1 more source

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication

Journal of Virology, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses, replicates their genome in virus-induced cytosolic membrane-bound replication organelles (ROs).
J. Li, Qi Gui, Feng-Xia Liang, Joseph Sall, Qingyue Zhang, Yatong Duan, Avantika Dhabaria, M. Askenazi, B. Ueberheide, Kenneth A. Stapleford, Michele Pagano   +10 more
semanticscholar   +1 more source

The impact of non-synonymous mutations on miRNA binding sites within the SARS-CoV-2 NSP3 and NSP4 genes

Scientific Reports, 2023
Non-synonymous mutations in the SARS-CoV-2 spike region affect cell entry, tropism, and immune evasion, while frequent synonymous mutations may modify viral fitness.
S. M. Ali Hosseini Rad, D. Wannigama, N. Hirankarn, Alexander D. McLellan   +3 more
semanticscholar   +1 more source

Rotavirus Protein NSP3 Shuts Off Host Cell Protein Synthesis [PDF]

, 2002
A recombinant vaccinia virus encoding rotavirus protein NSP3 driven by an internal ribosome entry site (IRES) from the encephalomyocarditis (EMC) virus was able to abate protein synthesis in BSC1 cells by 25-fold, with as much as 30% of the remaining ...
Guzmán-León, Simón, Padilla-Noriega, Luis, Paniagua, Octavio   +2 more
core   +1 more source

Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N)

Majalah Obat Tradisional, 2022
Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV.
Roihatul Mutiah, Chamlah Ayatillah, Yen yen Ari Indrawijaya, Arief Suryadinata   +3 more
doaj   +1 more source

Characterising the role of the nsP3 macro domain in Chikungunya virus replication [PDF]

, 2018
Chikungunya virus (CHIKV) causes an acute fever with debilitating joint pain. Spread by the Aedes species of mosquito, recent increases in global temperature, and mutations in the viral glycoproteins have facilitated outbreaks worldwide with huge ...
Roberts, Grace Charlotte
core   +6 more sources