Results 41 to 50 of about 14,170 (209)

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis [PDF]

Journal of Medical Virology, 2020
AbstractLast December 2019, a new virus, named novel Coronavirus (COVID‐2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID‐2019 pathogenesis. The Open Reading Frame 1ab (ORF1ab) of COVID‐2019 has been analyzed to evidence the presence of mutation caused by selective ...
Silvia Angeletti, Domenico Benvenuto, Martina Bianchi, Marta Giovanetti, Stefano Pascarella, Massimo Ciccozzi   +5 more
openaire   +3 more sources

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]

Open Biology, 2016
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte, Lifeng Liu, Marc D. Panas, Bastian Thaa, Nicole Dickson, Benjamin Götte, Adnane Achour, Gerald M. McInerney   +7 more
doaj   +1 more source

Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity.

PLoS Neglected Tropical Diseases, 2023
Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people.
Nathaniel M Byers, Paul L Burns, Olga Stuchlik, Matthew S Reed, Jeremy P Ledermann, Jan Pohl, Ann M Powers   +6 more
doaj   +1 more source

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

Structure of the X (ADRP) domain of nsp3 from feline coronavirus [PDF]

Acta Crystallographica Section D Biological Crystallography, 2009
The structure of the X (or ADRP) domain of a pathogenic variant of feline coronavirus (FCoV) has been determined in tetragonal and cubic crystal forms to 3.1 and 2.2 A resolution, respectively. In the tetragonal crystal form, glycerol-3-phosphate was observed in the ADP-ribose-binding site.
Wojdyla, J. A., Manolaridis, I., Snijder, E. J., Gorbalenya, A. E., Coutard, B., Piotrowski, Y., Hilgenfeld, R., Tucker, P. A.   +7 more
openaire   +3 more sources

Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy

Pharmaceuticals, 2022
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges (NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared.
Md. Khalid Anwer, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Muzaffar Iqbal, Vinay Kumar   +4 more
doaj   +1 more source

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus

Parasites & Vectors, 2015
Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros, Corinne Geertsema, Karima Zouache, Jim Baggen, Natalia Domeradzka, Daniël M. van Leeuwen, Jacky Flipse, Just M. Vlak, Anna-Bella Failloux, Gorben P. Pijlman   +9 more
doaj   +1 more source

Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA [PDF]

Journal of Virology, 1994
The alphavirus mutant Sindbis virus HR ts4, which has been assigned to the A complementation group, possessed a selective defect in negative-strand synthesis that was similar although not identical to that observed for the B complementation group mutant ts11 (Y.-F. Wang, S. G. Sawicki, and D. L. Sawicki, J. Virol. 65:985-988, 1991). The causal mutation
Y F, Wang, S G, Sawicki, D L, Sawicki
openaire   +2 more sources

Novel Functions of the Alphavirus Nonstructural Protein nsP3 C-Terminal Region [PDF]

Journal of Virology, 2010
ABSTRACT The functions of the alphavirus-encoded nonstructural protein nsP3 during infection are poorly understood. In contrast, nsP1, nsP2, and nsP4 have known enzymatic activities and functions. A functional analysis of the C-terminal region of nsP3 of Semliki Forest virus revealed the presence of a degradation signal that ...
Margus, Varjak, Eva, Zusinaite, Andres, Merits   +2 more
openaire   +2 more sources