Results 41 to 50 of about 9,079 (162)
PLoS Neglected Tropical Diseases, 2023 Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people.
Nathaniel M Byers +6 more
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Majalah Obat Tradisional, 2022 Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV.
Roihatul Mutiah +3 more
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Parasites & Vectors, 2015 Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros +9 more
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Frontiers in Cell and Developmental Biology, 2021 Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee +6 more
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Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex [PDF]
Journal of Virology, 2015 ABSTRACT Through its interaction with the 5′ translation initiation factor eIF4G, poly(A) binding protein (PABP) facilitates the translation of 5′-capped and 3′-poly(A)-tailed mRNAs. Rotavirus mRNAs are capped but not polyadenylated, instead terminating in a 3′ GACC motif that is recognized by the viral protein NSP3, which competes ...
Gratia, Matthieu +7 more
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Viruses, 2018 Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Margit Mutso +13 more
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Pharmaceuticals, 2022 In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges (NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared.
Md. Khalid Anwer +4 more
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Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
Antiviral Research, 2018 The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of ...
Lei, Jian, Kusov, Yuri, Hilgenfeld, Rolf
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Predicted binding interface between coronavirus nsp3 and nsp4 [PDF]
, 2022 Abstract Double membrane vesicles (DMVs) in coronavirus-infected cells feature pores that span both membranes. DMV pores were observed to have six-fold symmetry and include the nsp3 protein. Co-expression of SARS-CoV nsp3 and nsp4 induces DMV formation, and elements of nsp3 and nsp4 have been identified that are essential for membrane ...
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Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]
SLAS Discovery, 2020 ABSTRACT Small molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus’ ability to evade cellular detection.
Rajdeep S. Virdi +6 more
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