Results 1 to 10 of about 102 (85)
Research Progress on the Structure and Function of G3BP
Frontiers in Immunology, 2021 Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding protein. G3BP is a key component of stress granules (SGs) and can interact with many host proteins to regulate the expression of SGs.
Haixue Zheng, , Zheng Haixue
exaly +3 more sources
Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain
Frontiers in Cellular and Infection Microbiology, 2022 Ras-GTPase-activating SH3 domain-binding-proteins 1 (G3BP1) and 2 (G3BP2) are multifunctional RNA-binding proteins involved in stress granule nucleation, previously identified as essential cofactors of Old World alphaviruses.
Laurence Briant +2 more
exaly +3 more sources
The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs
Cell Reports, 2020 Summary: G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed cells, where RIN is not SG associated. Immunoprecipitation followed by microarray analysis
Stéphane Angers +2 more
exaly +3 more sources
Cell Reports, 2023 Summary: Stress granules (SGs) constitute a signaling hub that plays a critical role in type I interferon responses. Here, we report that growth arrest and DNA damage-inducible beta (Gadd45β) act as a positive regulator of SG-mediated interferon ...
W.A. Gayan Chathuranga +10 more
exaly +3 more sources
PLoS Pathogens, 2021 Both cellular and viral proteins can undergo phase separation and form membraneless compartments that concentrate biomolecules. The p26 movement protein from single-stranded, positive-sense Pea enation mosaic virus 2 (PEMV2) separates into a dense phase ...
Shelby L Brown +2 more
doaj +1 more source
Nuclear Localization of G3BP6 Is Essential for the Flowering Transition in Arabidopsis
Biomolecules, 2023 The Ras GTPase-activating protein SH3 domain-binding protein (G3BP) belongs to the highly conserved family of RNA-binding proteins, which has been well-investigated in humans and animals.
Yuzhu Wang +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee +6 more
doaj +1 more source
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]
Open Biology, 2016 Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte +7 more
doaj +1 more source
Comprehensive evolutionary analysis and nomenclature of plant G3BPs
Life Science Alliance, 2022 A thorough phylogenetic analysis of eukaryotic G3BPs (Rasputins) with a focus on plant G3BP proteins, classification into two subfamilies and a proposed systematic nomenclature.
Aala A Abulfaraj +6 more
doaj +1 more source
Analyzing the G3BP-like gene family of Arabidopsis thaliana in early turnip mosaic virus infection
Scientific Reports, 2021 The Arabidopsis thaliana genome encodes several genes that are known or predicted to participate in the formation of stress granules (SG). One family of genes encodes for Ras GTPase-activating protein–binding protein (G3BP)-like proteins.
Hendrik Reuper +2 more
doaj +1 more source