Results 31 to 40 of about 4,644 (183)

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling [PDF]

Cell, 2021
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (TSC) protein complex to lysosomes and suppress ...
Prentzell, Mirja Tamara, Rehbein, Ulrike, Sandoval, Marti Cadena, De Meulemeester, Ann-Sofie, Baumeister, Ralf, Brohee, Laura, Berdel, Bianca, Bockwoldt, Mathias, Carroll, Bernadette, Chowdhury, Suvagata Roy, von Deimling, Andreas, Demetriades, Constantinos, Figlia, Gianluca, de Araujo, Mariana Eca Guimaraes, Heberle, Alexander M., Heiland, Ines, Holzwarth, Birgit, Huber, Lukas A., Jaworski, Jacek, Kedra, Magdalena, Kern, Katharina, Kopach, Andrii, Korolchuk, Viktor, van't Land-Kuper, Ineke, Macias, Matylda, Nellist, Mark, Palm, Wilhelm, Pusch, Stefan, Pittol, Jose Miguel Ramos, Reil, Michele, Reintjes, Anja, Reuter, Friederike, Sampson, Julian R., Scheldeman, Chloe, Siekierska, Aleksandra, Stefan, Eduard, Teleman, Aurelio A., Thomas, Laura E., Torres-Quesada, Omar, Trump, Saskia, West, Hannah D., de Witte, Peter, Woltering, Sandra, Yordanov, Teodor E., Zmorzynska, Justyna, Opitz, Christiane A., Thedieck, Kathrin   +46 more
openaire   +11 more sources

Alphavirus-host interactions : how to unravel the proviral activity of G3BP

, 2019
The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically distinguished into Old World and New World alphaviruses.
Benjamin Götte (18672085)
openaire   +2 more sources

The G3BP stress-granule proteins reinforce the integrated stress response translation programme. [PDF]

Nat Cell Biol
ABSTRACT When mammalian cells are exposed to stress, they coordinate the condensation of stress granules (SGs) through the action of proteins G3BP1 and G3BP2 (G3BPs) and, simultaneously, undergo a massive reduction in translation. Although SGs and G3BPs have been linked to this translation response, their overall impact has been unclear.
Smith J, Bartel DP.
europepmc   +4 more sources

Phase separation of a plant virus movement protein and cellular factors support virus-host interactions.

PLoS Pathogens, 2021
Both cellular and viral proteins can undergo phase separation and form membraneless compartments that concentrate biomolecules. The p26 movement protein from single-stranded, positive-sense Pea enation mosaic virus 2 (PEMV2) separates into a dense phase ...
Shelby L Brown, Dana J Garrison, Jared P May   +2 more
doaj   +1 more source

Nuclear Localization of G3BP6 Is Essential for the Flowering Transition in Arabidopsis

Biomolecules, 2023
The Ras GTPase-activating protein SH3 domain-binding protein (G3BP) belongs to the highly conserved family of RNA-binding proteins, which has been well-investigated in humans and animals.
Yuzhu Wang, Zhiyong Li, Xiaoju Liang, Yeling Zhou, Jiansheng Liang   +4 more
doaj   +1 more source

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]

Open Biology, 2016
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte, Lifeng Liu, Marc D. Panas, Bastian Thaa, Nicole Dickson, Benjamin Götte, Adnane Achour, Gerald M. McInerney   +7 more
doaj   +1 more source

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells [PDF]

Journal of Visualized Experiments, 2014
SGs can be visualized in cells by immunostaining of specific protein components or polyA+ mRNAs. SGs are highly dynamic and the study of their assembly and fate is important to understand the cellular response to stress. The deficiency in key factors of SGs like G3BP (RasGAP SH3 domain Binding Protein) leads to developmental defects in mice and ...
Martin, S., Chebli, K., Tazi, J.
openaire   +3 more sources

Identification of small molecule inhibitors of G3BP-driven stress granule formation

Journal of Cell Biology, 2023
ABSTRACT Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the paralogs G3BP1 and G3BP2. G3BP1/2 proteins bind mRNAs and thereby promote the condensation of mRNPs into stress granules.
Brian D. Freibaum, James Messing, Haruko Nakamura, Ugur Yurtsever, Jinjun Wu, Hong Joo Kim, Jeff Hixon, Rene Marc Lemieux, Jay Duffner, Walter Huynh, Kathy Wong, Michael White, Christina Lee, Rachel E. Meyers, Roy Parker, J. Paul Taylor   +15 more
openaire   +3 more sources

Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis [PDF]

World Journal of Gastroenterology, 2007
To investigate the expression and significance of G3BP and RhoC proteins in esophageal squamous carcinoma (ESC).The expression of G3BP and Rhoc proteins in 80 cases of ESC was detected by immunohistochemistry. The relationship was studied between the expression of the two proteins and tumor size, differentiation degree, TNM stage, lymph node metastasis
Hui-Zhong, Zhang, Jin-Geng, Liu, Yi-Ping, Wei, Cheng, Wu, Yong-Ke, Cao, Mei, Wang   +5 more
openaire   +2 more sources