Results 31 to 40 of about 5,954 (200)

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. [PDF]

, 2015
Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013).
Ingolia, Nicholas T, McGeachy, Anna M, Sidrauski, Carmela, Walter, Peter   +3 more
core   +2 more sources

G3BP isoforms differentially affect stress granule assembly and gene expression during cellular stress. [PDF]

Mol Biol Cell
Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these membraneless organelles is driven by the condensation of RNA and RNA-binding proteins such as G3BPs. G3BPs form SGs following stress-induced translational arrest.
Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN.   +10 more
europepmc   +5 more sources

Regulation of physiological and pathological condensates by molecular chaperones. [PDF]

FEBS J
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Akaree N, Secco V, Levy-Adam F, Younis A, Carra S, Shalgi R.   +5 more
europepmc   +2 more sources

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

Large G3BP-induced granules trigger eIF2α phosphorylation

Molecular Biology of the Cell, 2012
Stress granules are large messenger ribonucleoprotein (mRNP) aggregates composed of translation initiation factors and mRNAs that appear when the cell encounters various stressors. Current dogma indicates that stress granules function as inert storage depots for translationally silenced mRNPs until the cell signals for renewed translation and stress ...
Reineke, Lucas C., Dougherty, Jon D., Pierre, Philippe, Lloyd, Richard E.   +3 more
openaire   +2 more sources

ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. [PDF]

, 2019
Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation ...
Jurado, Andrea, Law, Lok Man John, Li, Melody MH, MacDonald, Margaret R, Razooky, Brandon S, Rice, Charles M, You, Shihyun   +6 more
core   +2 more sources

Analyzing the G3BP-like gene family of Arabidopsis thaliana in early turnip mosaic virus infection

Scientific Reports, 2021
The Arabidopsis thaliana genome encodes several genes that are known or predicted to participate in the formation of stress granules (SG). One family of genes encodes for Ras GTPase-activating protein–binding protein (G3BP)-like proteins.
Hendrik Reuper, Khalid Amari, Björn Krenz   +2 more
doaj   +1 more source

Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs [PDF]

, 2007
Caprin-1 is a ubiquitously expressed, well-conserved cytoplasmic phosphoprotein that is needed for normal progression through the G(1)-S phase of the cell cycle and occurs in postsynaptic granules in dendrites of neurons.
Solomon, Samuel, Xu, Yaoxian, Wang, Bin, D. David, Muriel, Schubert, Peter, Kennedy, Derek, W. Schrader, John   +6 more
core   +1 more source

Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner

Frontiers in Immunology, 2019
Background: Microvesicles (MVs) expressing the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP) may play a pathogenic role in systemic lupus erythematosus (SLE).
Niclas Stefan Rasmussen, Niclas Stefan Rasmussen, Christoffer Tandrup Nielsen, Søren Jacobsen, Claus Henrik Nielsen   +4 more
doaj   +1 more source

Crystal structures of the human G3BP1 NTF2-like domain visualize FxFG Nup repeat specificity. [PDF]

PLoS ONE, 2013
Ras GTPase Activating Protein SH3 Domain Binding Protein (G3BP) is a potential anti-cancer drug target implicated in several cellular functions. We have used protein crystallography to solve crystal structures of the human G3BP1 NTF2-like domain both ...
Tina Vognsen, Ingvar Runár Møller, Ole Kristensen   +2 more
doaj   +1 more source