Results 1 to 10 of about 43,794 (228)

Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target [PDF]

Journal of Translational Medicine, 2021
The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associated protein, while its role in innate immune ...
Emily Capone, Stefano Iacobelli, Gianluca Sala   +2 more
doaj   +6 more sources

Altered glycosylation of EVs in cancers: galectin-3-binding protein (LGALS3BP) [PDF]

Discover Oncology
Introduction Extracellular vesicles (EVs) are membrane-bound structures secreted by various cell types, acting as carriers of complex cargos that facilitate intercellular communication.
Jie-Yi Koh Kok, Bey-Hing Goh, Wai-Leng Lee   +2 more
doaj   +3 more sources

Visualizing Galectin-3 Binding Protein Expression with ImmunoPET. [PDF]

Mol Pharm, 2023
Galectin-3 binding protein (Gal-3BP) is a glycoprotein that is overexpressed and secreted by several cancers and has been implicated as a marker of both tumor progression and poor prognosis in melanoma, non-small cell lung cancer, head and neck squamous cell carcinoma, and breast cancer.
Keinänen O, Sarrett SM, Delaney S, Rodriguez C, Dayts EJ, Capone E, Sauniere F, Ippoliti R, Sala G, Iacobelli S, Zeglis BM.   +10 more
europepmc   +4 more sources

Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2. [PDF]

Mol Cell Proteomics, 2023
AbstractHuman extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-Osulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have shown that Sulf-2 is associated with poor ...
Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Nováková Z, Bařinka C, Goldman R.   +6 more
europepmc   +5 more sources

Galectin-3 Binding Protein, Depression, and Younger Age Were Independently Associated With Alexithymia in Adult Patients With Type 1 Diabetes [PDF]

Frontiers in Psychiatry, 2021
Aims: Alexithymia has been linked to cardiovascular disease. The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s)CD163 and galectin-3 were independently associated with alexithymia, while ...
Eva O. Melin, Eva O. Melin, Ralph Svensson, Jonatan Dereke, Magnus Hillman   +4 more
doaj   +2 more sources

Modulation of ocular surface glycocalyx barrier function by a galectin-3 N-terminal deletion mutant and membrane-anchored synthetic glycopolymers. [PDF]

PLoS ONE, 2013
Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx.
Jerome Mauris, Flavio Mantelli, Ashley M Woodward, Ziyhi Cao, Carolyn R Bertozzi, Noorjahan Panjwani, Kamil Godula, Pablo Argüeso   +7 more
doaj   +9 more sources

Urine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus. [PDF]

Lupus, 2023
Background Lupus nephritis (LN) is a major and severe organ involvement in systemic lupus erythematosus (SLE), whose diagnosis and treatment necessitate to perform kidney biopsy, which is an invasive procedure. Non-invasive urine biomarkers are an active area of investigation to support LN diagnosis and management.
Faustini F, Idborg H, Fuzzi E, Larsson A, Lie WR, Pötzsch S, Okitsu SL, Svenungsson E, Gunnarsson I.   +8 more
europepmc   +4 more sources

Serum galectin-3 and galectin-3 binding protein levels in systemic lupus erythematosus and cutaneous lupus erythematosus. [PDF]

Postepy Dermatol Alergol, 2021
The roles of galectin-3 (Gal-3) and galectin-3 binding protein (G3BP) in systemic lupus erythematosus (SLE) are of ongoing interest, but the data are insufficient due to highly limited available studies. There are no data on cutaneous lupus erythematosus (CLE).To assess serum Gal-3 and G3BP concentrations in SLE patients with and without LE-specific ...
Kalinska-Bienias A, Kowalczyk E, Bienias P, Gala K, Jagielski P, Kowalewski C.   +5 more
europepmc   +5 more sources

The role of galectin-3 and galectin-3-binding protein in venous thrombosis. [PDF]

Blood, 2015
Key PointsWe determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.
DeRoo EP, Wrobleski SK, Shea EM, Al-Khalil RK, Hawley AE, Henke PK, Myers DD, Wakefield TW, Diaz JA.   +8 more
europepmc   +5 more sources

Female sex, high soluble CD163, and low HDL-cholesterol were associated with high galectin-3 binding protein in type 1 diabetes [PDF]

Biology of Sex Differences, 2019
Background Galectin-3 binding protein (Gal3BP), sCD163, galectin-3, and depression have been linked to cardiovascular disease and mortality. In patients with type 1 diabetes, female sex has also been linked to cardiovascular disease and mortality.
Eva Olga Melin, Jonatan Dereke, Magnus Hillman   +2 more
doaj   +2 more sources