Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target [PDF]
Journal of Translational Medicine, 2021 The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associated protein, while its role in innate immune ...
Emily Capone +2 more
doaj +6 more sources
Altered glycosylation of EVs in cancers: galectin-3-binding protein (LGALS3BP) [PDF]
Discover OncologyIntroduction Extracellular vesicles (EVs) are membrane-bound structures secreted by various cell types, acting as carriers of complex cargos that facilitate intercellular communication.
Jie-Yi Koh Kok +2 more
doaj +4 more sources
Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction. [PDF]
J Clin Med, 2019 Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding ...
Gagno G +13 more
europepmc +6 more sources
Galectin-3 Binding Protein, Depression, and Younger Age Were Independently Associated With Alexithymia in Adult Patients With Type 1 Diabetes [PDF]
Frontiers in Psychiatry, 2021 Aims: Alexithymia has been linked to cardiovascular disease. The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s)CD163 and galectin-3 were independently associated with alexithymia, while ...
Eva O. Melin +4 more
doaj +2 more sources
Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection. [PDF]
Int J Mol Sci, 2016 Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined.
Liu KT +6 more
europepmc +4 more sources
Female sex, high soluble CD163, and low HDL-cholesterol were associated with high galectin-3 binding protein in type 1 diabetes [PDF]
Biology of Sex Differences, 2019 Background Galectin-3 binding protein (Gal3BP), sCD163, galectin-3, and depression have been linked to cardiovascular disease and mortality. In patients with type 1 diabetes, female sex has also been linked to cardiovascular disease and mortality.
Eva Olga Melin +2 more
doaj +2 more sources
Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis. [PDF]
Proc Natl Acad Sci U S A, 2022 Choi YS +17 more
europepmc +2 more sources
Galectin-3—A Multifunctional Molecule and a Key Player in Health and Disease [PDF]
MoleculesGalectins are a family of proteins that belong to one of the most widespread classes of lectins found in all organisms. They are found intracellularly in various structures or secreted into the extracellular space, where they are involved in mediating ...
Alina Lupu (Surlea) +7 more
doaj +2 more sources
Placental galectin-3 is reduced in early-onset preeclampsia
Frontiers in Physiology, 2022 Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells ...
Manju Kandel +17 more
doaj +1 more source
Computational Study of Potential Galectin-3 Inhibitors in the Treatment of COVID-19
Biomedicines, 2021 Galectin-3 is a carbohydrate-binding protein and the most studied member of the galectin family. It regulates several functions throughout the body, among which are inflammation and post-injury remodelling.
Maral Aminpour +12 more
doaj +1 more source