Results 31 to 40 of about 27,415 (188)

Phosphorylation of the β-Galactoside-binding Protein Galectin-3 Modulates Binding to Its Ligands [PDF]

Journal of Biological Chemistry, 2000
The beta-galactoside-binding protein galectin-3 has pleiotropic biological functions and has been implicated in cell growth, differentiation, adhesion, RNA processing, apoptosis, and malignant transformation. Galectin-3 may be phosphorylated at N-terminal Ser(6), but the role of phosphorylation in determining interactions of this endogenous lectin with
N, Mazurek, J, Conklin, J C, Byrd, A, Raz, R S, Bresalier   +4 more
openaire   +2 more sources

Glycodendrimers and Modified ELISAs: Tools to Elucidate Multivalent Interactions of Galectins 1 and 3

Molecules, 2015
Multivalent protein-carbohydrate interactions that are mediated by sugar-binding proteins, i.e., lectins, have been implicated in a myriad of intercellular recognition processes associated with tumor progression such as galectin-mediated cancer cellular
Mark Wolfenden, Jonathan Cousin, Pratima Nangia-Makker, Avraham Raz, Mary Cloninger   +4 more
doaj   +1 more source

Elevated serum levels of galectin-3 binding protein are associated with insulin resistance in non-diabetic women after menopause

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: Galectin-3 binding protein (Gal-3BP) is one of the major fucosylated glycoprotein family members and has recently been implicated in non-alcoholic fatty liver disease, hyperlipaemia and coronary artery disease.
Yun Chen, Sayantana Das, Guangchao Zhuo, Hong Cai   +3 more
doaj   +1 more source

Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure

Biochemical and Biophysical Research Communications, 2020
The β-galactoside-binding protein, galectin-3, is extensively involved in cancer development, progression and metastasis through multiple mechanisms. Inhibition of the galectin-3-mediated actions is increasingly considered as a promising therapeutic approach for cancer treatment.
Paulina Sindrewicz, Edwin A. Yates, Jeremy E. Turnbull, Lu-Yun Lian, Lu-Gang Yu   +4 more
openaire   +2 more sources

Zebrafish Galectin 3 binding protein is the target antigen of the microglial 4C4 monoclonal antibody

Developmental Dynamics, 2022
Abstract Background Two decades ago, the fish‐specific monoclonal antibody 4C4 was found to be highly reactive to zebrafish microglia, the macrophages of the central nervous system. This has resulted in 4C4 being widely used, in combination with available fluorescent transgenic reporters to ...
Mireia Rovira, Magali Miserocchi, Alice Montanari, Latifa Hammou, Laura Chomette, Jennifer Pozo, Virginie Imbault, Xavier Bisteau, Valérie Wittamer   +8 more
openaire   +3 more sources

New clues arising from hunt of saccharides binding to galectin 3 via 3D QSAR and docking studies

Informatics in Medicine Unlocked, 2020
Galectin-3 is a carbohydrate-binding protein that plays a crucial role in cancer and fibrosis. Its inhibitors have largely evolved from naturally occurring saccharides to many synthetic forms with significantly improved affinity.
Aaftaab Sethi, Swetha Sanam, Mallika Alvala   +2 more
doaj   +1 more source

Acute hantavirus infection induces galectin-3-binding protein

Journal of General Virology, 2014
Hantaviruses are zoonotic viruses that cause life-threatening diseases when transmitted to humans. Severe hantavirus infection is manifested by impairment of renal function, pulmonary oedema and capillary leakage. Both innate and adaptive immune responses contribute to the pathogenesis, but the underlying mechanisms are not fully understood.
Vaheri Antti, Lankinen Hilkka, Sane Jussi, Hepojoki Jussi, Vapalahti Olli, Meri Seppo, Sironen Tarja, Strandin Tomas, Hetzel Udo, Mustonen Jukka, Mäkelä Satu, Vaheri Antti, Lankinen Hilkka, Sane Jussi, Hepojoki Jussi, Vapalahti Olli, Meri Seppo, Sironen Tarja, Strandin Tomas, Hetzel Udo, Tuntematon   +20 more
openaire   +3 more sources

Pseudomonas aeruginosa lipopolysaccharide binds galectin-3 and other human corneal epithelial proteins [PDF]

Infection and Immunity, 1997
The aim of this study was to test whether galectin-3 is present in human corneal epithelium and whether lipopolysaccharide (LPS) purified from Pseudomonas aeruginosa ATCC 19660 binds to this animal lectin and/or to another human corneal epithelial protein(s) (HCEP) and to confirm which component of LPS (inner or outer core or lipid A) is important in ...
S K, Gupta, S, Masinick, M, Garrett, L D, Hazlett   +3 more
openaire   +2 more sources

Galectin-3 Plays an Important Role in BMP7-Induced Cementoblastic Differentiation of Human Periodontal Ligament Cells by Interacting with Extracellular Components

Stem Cells International, 2023
Human periodontal ligament stem cells (hPDLSCs) contain multipotent postnatal stem cells that differentiate into PDL progenitors, osteoblasts, and cementoblasts.
Min-Jeong Choi, Tae Min You, Young-Joo Jang   +2 more
doaj   +1 more source

Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1

Frontiers in Cell and Developmental Biology, 2019
Galectin-3 (encoded by LGALS3) is a glycan-binding protein that regulates a diverse range of pathophysiological processes contributing to the pathogenesis of human diseases. Previous studies have found that galectin-3 levels are up-regulated in the liver
Zilong Li, Fangqiao Lv, Congxin Dai, Qiong Wang, Chao Jiang, Mingming Fang, Mingming Fang, Yong Xu, Yong Xu   +8 more
doaj   +1 more source