Results 51 to 60 of about 27,415 (188)

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners [PDF]

Cells, 2019
Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectases ...
Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla, Carmelo Bernabeu   +7 more
openaire   +7 more sources

A Truncated Galectin-3 Isolated from Skin Mucus of Atlantic Salmon Salmo salar Binds to and Modulates the Proteome of the Gram-Negative Bacteria Moritella viscosa

Marine Drugs, 2020
The mucus of fish skin plays a vital role in innate immune defense. Some mucus proteins have the potential to incapacitate pathogens and/or inhibit their passage through the skin.
Deepti Manjari Patel, Yoichiro Kitani, Kjetil Korsnes, Martin Haugmo Iversen, Monica Fengsrud Brinchmann   +4 more
doaj   +1 more source

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration

Journal of Neuroinflammation, 2022
Background Dysfunctional humoral and cellular innate immunity are key components in the development and progression of age-related macular degeneration (AMD).
Mona Tabel, Anne Wolf, Manon Szczepan, Heping Xu, Herbert Jägle, Christoph Moehle, Mei Chen, Thomas Langmann   +7 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Binding of Gold(III) Porphyrin by the Pro-metastatic Regulatory Protein Human Galectin-3 [PDF]

Molecules, 2019
Gold(III) porphyrin presents an attractive alternative to the use of, for example, cisplatin in chemotherapy. However, approaches that allow to selectively target cancer cells are highly sought. Many plant and mammalian lectins have been shown to bind oligosaccharide sequences of the aberrant glycosylation pattern found on cancerous tumors. For example
Bogoeva, Vanya, Rangelov, Miroslav, Todorova, Nadezhda, Lambert, Annie, Bridot, Clarisse, Yordanova, Anna, Roos, Goedele, Grandjean, Cyrille, Bouckaert, Julie   +8 more
openaire   +4 more sources

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

Galectin-3 determines tumor cell adaptive strategies in stressed tumor microenvironments

Frontiers in Oncology, 2016
Galectin-3 is a member of the b-galactoside binding lectin family, whose expression is often dysregulated in cancers. While galectin-3 is usually an intracellular protein, found in the nucleus and in the cytoplasm; under certain conditions, galectin-3 ...
Ana Carolina Ferreira Cardoso, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger eChammas   +3 more
doaj   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

The Expression of Galectin-3, a Beta-Galactoside Binding Protein, in Dendritic Cells

Immune Network, 2005
Dendritic cells (DCs) are the most potent APCs (antigen-presenting cells) and playa critical role in immune responses. Galectin-3 is a biological lectin with a beta-galactoside binding affinity. Recently, proteomic analysis revealed the presence of galectin-3 in the exosome of mature DCs.
Mi-Hyoung Kim, Hong-Gu Joo
openaire   +1 more source

Duodenal Intraepithelial Lymphocytes of Children with Cow Milk Allergy Preferentially Bind the Glycan-Binding Protein Galectin-3 [PDF]

International Journal of Immunopathology and Pharmacology, 2009
A breakdown in intestinal homeostasis results in inflammatory bowel diseases including coeliac disease and allergy. Galectins, evolutionarily conserved β-galactoside-binding proteins, can modulate immune-epithelial cell interactions by influencing immune cell fate and cytokine secretion.
Mercer, Natalia, Guzman, Luciana, Cueto Rua, Eduardo, Drut, Ricardo, Ahmed, H., Vasta, G. R., Toscano, Marta Alicia, Rabinovich, Gabriel Adrián, Docena, Guillermo Horacio   +8 more
openaire   +4 more sources