Results 51 to 60 of about 43,794 (228)

Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1

Frontiers in Cell and Developmental Biology, 2019
Galectin-3 (encoded by LGALS3) is a glycan-binding protein that regulates a diverse range of pathophysiological processes contributing to the pathogenesis of human diseases. Previous studies have found that galectin-3 levels are up-regulated in the liver
Zilong Li, Fangqiao Lv, Congxin Dai, Qiong Wang, Chao Jiang, Mingming Fang, Mingming Fang, Yong Xu, Yong Xu   +8 more
doaj   +1 more source

Galectin-3 Plays an Important Role in BMP7-Induced Cementoblastic Differentiation of Human Periodontal Ligament Cells by Interacting with Extracellular Components

Stem Cells International, 2023
Human periodontal ligament stem cells (hPDLSCs) contain multipotent postnatal stem cells that differentiate into PDL progenitors, osteoblasts, and cementoblasts.
Min-Jeong Choi, Tae Min You, Young-Joo Jang   +2 more
doaj   +1 more source

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]

, 2017
Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena, Carabias, Pablo, Troncoso, María Fernanda   +2 more
core   +1 more source

Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

BMJ Open Diabetes Research & Care, 2021
Introduction Childhood obesity (OB) and metabolic syndrome (MetS) have become a worldwide health problem. Comparative proteomic approaches are widely used in human OB to analyze protein changes in blood plasma. The present study determined the galectin-3
Zhongyi Zhao, Deliang Wen, Shihan Zhen, Yanan Ma, Yanshuo Han   +4 more
doaj   +1 more source

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1 [PDF]

, 2016
Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated.
Abramoff, Ada G. Blidner, Amrita Rao, Boehme, Gabriel A. Rabinovich, Ge, Ha, He, Idil Bastan, Matsuura, P. Sriramarao, Rabinovich, Savita P. Rao, Sung Gil Ha, Xiao Na Ge, Yana G. Greenberg   +15 more
core   +1 more source

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners [PDF]

Cells, 2019
Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectases ...
Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla, Carmelo Bernabeu   +7 more
openaire   +7 more sources

Soluble IgE‐binding factors in the serum of food‐allergic patients: Possible pathophysiological role of soluble FcεRI as protective factor

Clinical and Translational Allergy, 2023
Background IgE‐mediated food allergy is the result of an aberrant immune response involving the interaction of a food allergen with its specific IgE bound to FcɛRI, the high affinity IgE receptor, on mast cells.
Carolin Steinert, Sherezade Moñino‐Romero, Monique Butze, Jörg Scheffel, Sabine Dölle‐Bierke, Josefine Dobbertin‐Welsch, Kirsten Beyer, Marcus Maurer, Sabine Altrichter   +8 more
doaj   +1 more source

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Nature Communications, 2016
Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and ...
Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen   +9 more
doaj   +1 more source

Evaluation of galectin-3 and other biochemical parameters in chronic kidney disease patients on hemodialysis in Erbil city

Zanco Journal of Medical Sciences, 2023
Background and objective: Chronic kidney disease represents a leading cause of death in many countries. End-stage renal disease is the final stage of chronic kidney disease, in which the kidneys are no longer function well enough for the patient to live ...
Zereen M. Abdullah, Kamaran Y. Mohammadamin   +1 more
doaj   +1 more source

Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

PLoS ONE, 2013
Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette (ABC) transporters and induction of galectin-3 signaling. Galectin-3 plays an anti-apoptotic role
Yung-Kuo Lee, Tsung-Hsien Lin, Chuan-Fa Chang, Yu-Li Lo   +3 more
doaj   +1 more source