Results 41 to 50 of about 27,415 (188)

Human Milk Galectin-3 Binding Protein and Breast-feeding–associated HIV Transmission [PDF]

Pediatric Infectious Disease Journal, 2013
Analysis of milk from 247 HIV-infected Zambian mothers showed that galectin-3 binding protein concentrations were significantly higher among HIV-infected mothers who transmitted HIV through breast-feeding (6.51 ± 2.12 μg/mL) than among nontransmitters but were also correlated with higher milk and plasma HIV RNA copies/mL and lower CD4+ cell counts. The
Christina S, Chan, Hae-Young, Kim, Chloe, Autran, Jae H, Kim, Moses, Sinkala, Chipepo, Kankasa, Mwiya, Mwiya, Donald M, Thea, Grace M, Aldrovandi, Louise, Kuhn, Lars, Bode   +10 more
openaire   +2 more sources

Soluble IgE‐binding factors in the serum of food‐allergic patients: Possible pathophysiological role of soluble FcεRI as protective factor

Clinical and Translational Allergy, 2023
Background IgE‐mediated food allergy is the result of an aberrant immune response involving the interaction of a food allergen with its specific IgE bound to FcɛRI, the high affinity IgE receptor, on mast cells.
Carolin Steinert, Sherezade Moñino‐Romero, Monique Butze, Jörg Scheffel, Sabine Dölle‐Bierke, Josefine Dobbertin‐Welsch, Kirsten Beyer, Marcus Maurer, Sabine Altrichter   +8 more
doaj   +1 more source

Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

BMJ Open Diabetes Research & Care, 2021
Introduction Childhood obesity (OB) and metabolic syndrome (MetS) have become a worldwide health problem. Comparative proteomic approaches are widely used in human OB to analyze protein changes in blood plasma. The present study determined the galectin-3
Zhongyi Zhao, Deliang Wen, Shihan Zhen, Yanan Ma, Yanshuo Han   +4 more
doaj   +1 more source

Developing Galectin-3-Targeted Therapeutics in Diseases: Three Distinct Galectin-3 Segments for Targeting

Expert Reviews in Molecular Medicine
The β-galactoside-binding protein galectin-3 is currently a hotly pursued therapeutic target in cancer, inflammation and fibrosis-associated diseases due to its multi-mode actions and broad impact on the pathogenesis and progress of the diseases. Various
Paulina Sindrewicz-Goral, Oluwatobi Adegbite, Jessie Y. Yu, Lu-Gang Yu   +3 more
doaj   +1 more source

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Nature Communications, 2016
Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and ...
Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen   +9 more
doaj   +1 more source

Evaluation of galectin-3 and other biochemical parameters in chronic kidney disease patients on hemodialysis in Erbil city

Zanco Journal of Medical Sciences, 2023
Background and objective: Chronic kidney disease represents a leading cause of death in many countries. End-stage renal disease is the final stage of chronic kidney disease, in which the kidneys are no longer function well enough for the patient to live ...
Zereen M. Abdullah, Kamaran Y. Mohammadamin   +1 more
doaj   +1 more source

Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

PLoS ONE, 2013
Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette (ABC) transporters and induction of galectin-3 signaling. Galectin-3 plays an anti-apoptotic role
Yung-Kuo Lee, Tsung-Hsien Lin, Chuan-Fa Chang, Yu-Li Lo   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Galectin-3 and Its Binding Protein, Interleukin-6, and C-Reactive Protein in the Serum of Patients with Rheumatoid Arthritis in Iraq

Medical Journal of Babylon
Background: Rheumatoid arthritis is an autoimmune, systemic, chronic, and inflammatory disorder of obscure source that is differentiated by symmetric, polyarticular pain and tumefaction, stiffness in the first hours of the morning, and lassitude ...
Ahmed Jabbar Abbas Alsaidi, Maha Fadhil Smaism, Ali Mohammed Hussain Alkazzaz   +2 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source