Taiwanese Journal of Obstetrics & Gynecology, 2020 Objective: Galectin-3 binding protein (Gal-3BP) is one of the major fucosylated glycoprotein family members and has recently been implicated in non-alcoholic fatty liver disease, hyperlipaemia and coronary artery disease.
Yun Chen +3 more
doaj +1 more source
Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]
, 2005 Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines +5 more
core +1 more source
Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins [PDF]
, 1998 The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of ...
Bovin, N. V. +11 more
core +10 more sources
New clues arising from hunt of saccharides binding to galectin 3 via 3D QSAR and docking studies
Informatics in Medicine Unlocked, 2020 Galectin-3 is a carbohydrate-binding protein that plays a crucial role in cancer and fibrosis. Its inhibitors have largely evolved from naturally occurring saccharides to many synthetic forms with significantly improved affinity.
Aaftaab Sethi +2 more
doaj +1 more source
Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure
Biochemical and Biophysical Research Communications, 2020 The β-galactoside-binding protein, galectin-3, is extensively involved in cancer development, progression and metastasis through multiple mechanisms. Inhibition of the galectin-3-mediated actions is increasingly considered as a promising therapeutic approach for cancer treatment.
Paulina Sindrewicz +4 more
openaire +2 more sources
Human Milk Galectin-3 Binding Protein and Breast-feeding–associated HIV Transmission [PDF]
Pediatric Infectious Disease Journal, 2013 Analysis of milk from 247 HIV-infected Zambian mothers showed that galectin-3 binding protein concentrations were significantly higher among HIV-infected mothers who transmitted HIV through breast-feeding (6.51 ± 2.12 μg/mL) than among nontransmitters but were also correlated with higher milk and plasma HIV RNA copies/mL and lower CD4+ cell counts. The
Christina S, Chan +10 more
openaire +2 more sources
Nutrient-responsive O-GlcNAcylation dynamically modulates the secretion of glycan-binding protein galectin 3 [PDF]
Journal of Biological Chemistry, 2022 Endomembrane glycosylation and cytoplasmic O-GlcNAcylation each play essential roles in nutrient sensing, and characteristic changes in glycan patterns have been described in disease states such as diabetes and cancer. These changes in glycosylation have important functional roles and can drive disease progression.
Mathew, Mohit P. +3 more
openaire +2 more sources
The Third Dimension of Reading the Sugar Code by Lectins [PDF]
, 2013 Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
André, Sabine +2 more
core +3 more sources
Human Galectin 3 Binding Protein Interacts with Recombinant Adeno-Associated Virus Type 6 [PDF]
Journal of Virology, 2012 ABSTRACT Recombinant adeno-associated viruses (rAAVs) hold enormous potential for human gene therapy. Despite the well-established safety and efficacy of rAAVs for in vivo gene transfer, there is still little information concerning the fate of vectors in blood following systemic delivery.
Denard, J. +11 more
openaire +3 more sources
Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins [PDF]
, 2011 Thioglycosides offer the advantage over O-glycosides to be resistant to hydrolysis. Based on initial evidence of this recognition ability for glycosyldisulfides by screening dynamic combinatorial libraries, we have now systematically studied ...
Aguilera +91 more
core +2 more sources