Results 61 to 70 of about 43,794 (228)

Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer [PDF]

, 2005
Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers.
Akos Horvath, Andre S, Andre S, Andre S, Andre S, Andre S, Arnusch CJ, Buttery R, Elad-Sfadia G, Gabius HJ, Gabius HJ, Gabius HJ, Hans-Joachim Gabius, Imre Trojan, Jan-Dirk Baumhäkel, Jozsef Furak, Kaltner H, Kayser K, Kayser K, Kayser K, Kayser K, Klaus Kayser, Kopitz J, Kornelia Szluha, Lahm H, Laszlo Tiszlavicz, Liu FT, Moon BK, Nangia-Makker P, Puglisi F, Rappl G, Rorive S, Sabine Andre, Sheikholeslam-Zadeh R, Siebert HC, Tamas Szöke   +35 more
core   +1 more source

Duodenal Intraepithelial Lymphocytes of Children with Cow Milk Allergy Preferentially Bind the Glycan-Binding Protein Galectin-3 [PDF]

International Journal of Immunopathology and Pharmacology, 2009
A breakdown in intestinal homeostasis results in inflammatory bowel diseases including coeliac disease and allergy. Galectins, evolutionarily conserved β-galactoside-binding proteins, can modulate immune-epithelial cell interactions by influencing immune cell fate and cytokine secretion.
Mercer, Natalia, Guzman, Luciana, Cueto Rua, Eduardo, Drut, Ricardo, Ahmed, H., Vasta, G. R., Toscano, Marta Alicia, Rabinovich, Gabriel Adrián, Docena, Guillermo Horacio   +8 more
openaire   +4 more sources

β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors. [PDF]

Chembiochem
Galacto‐mimicking mannosyl monotriazoles, but not bis‐triazoles, inhibit galectin‐3 and galectin‐9 N‐terminal domain. Mannosyl β‐C‐1 amidotriazoles have previously been reported to have higher selectivity for galectin‐9N (N‐terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin‐3.
Sjövall F, Nilsson UJ.
europepmc   +2 more sources

A Truncated Galectin-3 Isolated from Skin Mucus of Atlantic Salmon Salmo salar Binds to and Modulates the Proteome of the Gram-Negative Bacteria Moritella viscosa

Marine Drugs, 2020
The mucus of fish skin plays a vital role in innate immune defense. Some mucus proteins have the potential to incapacitate pathogens and/or inhibit their passage through the skin.
Deepti Manjari Patel, Yoichiro Kitani, Kjetil Korsnes, Martin Haugmo Iversen, Monica Fengsrud Brinchmann   +4 more
doaj   +1 more source

Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy [PDF]

, 2011
Increasing insights into the involvement of endogenous lectins in disease processes fuel the interest to develop potent inhibitors. As a consequence, robust assay procedures are required. Due to their activity as adhesion/growth-regulatory effectors this
André, Sabine, Büchner, Claudia, Doose, Sören, Gabius, Hans-Joachim, Göhler, Antonia, Kaltner, Herbert   +5 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration

Journal of Neuroinflammation, 2022
Background Dysfunctional humoral and cellular innate immunity are key components in the development and progression of age-related macular degeneration (AMD).
Mona Tabel, Anne Wolf, Manon Szczepan, Heping Xu, Herbert Jägle, Christoph Moehle, Mei Chen, Thomas Langmann   +7 more
doaj   +1 more source

The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy [PDF]

, 2016
This project was funded by NHS Grampian R&D project number RG05/019Peer ...
Al-Gubory, Kaïs, Arianmanesh, Mitra, Fowler, Paul A   +2 more
core   +2 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Galectin-3 determines tumor cell adaptive strategies in stressed tumor microenvironments

Frontiers in Oncology, 2016
Galectin-3 is a member of the b-galactoside binding lectin family, whose expression is often dysregulated in cancers. While galectin-3 is usually an intracellular protein, found in the nucleus and in the cytoplasm; under certain conditions, galectin-3 ...
Ana Carolina Ferreira Cardoso, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger eChammas   +3 more
doaj   +1 more source