Results 1 to 10 of about 4,725,206 (152)

Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion [PDF]

Nature Communications
Galectins play vital roles in cellular processes such as adhesion, communication, and survival, yet the mechanisms underlying their unconventional secretion remain poorly understood.
Wenting Zhang, Cuicui Ji, Xianghua Li, Tianlong He, Wei Jiang, Yukun Liu, Meiling Wu, Yunpeng Zhao, Xuechai Chen, Xiaoli Wang, Jian Li, Haolin Zhang, Juan Wang   +12 more
doaj   +3 more sources

"Galectin-9: A double-edged sword in Acute Myeloid Leukemia". [PDF]

Ann Hematol
Acute Myeloid Leukemia (AML) presents a formidable challenge in the realm of hematologic malignancies, characterized by the unregulated proliferation of myeloid progenitor cells, leading to severe disruptions in normal hematopoiesis. This review examines
Aval OS, Ahmadi A, Hemid Al-Athari AJ, Soleimani Samarkhazan H, Sotudeh Chafi F, Asadi M, Mohammadi MH, Aghaei M.   +7 more
europepmc   +2 more sources

Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells

Hematology, 2023
The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, the regulation of Tim-3/Galectin-9 on CD4 T cell subsets in multiple myeloma (MM) remains unclear. The aim of this study was to
Rui Zhang, Shuang Chen, Tingting Luo, Sha Guo, Jianhua Qu   +4 more
doaj   +2 more sources

Galectin-9-An Emerging Glyco-Immune Checkpoint Target for Cancer Therapy. [PDF]

Int J Mol Sci
Galectin-9 (Gal-9, LGALS9) is a member of the family of carbohydrate-binding lectins known as galectins. Galectins bind a diverse repertoire of galactose-bearing glycoprotein receptors expressed across multiple cell types.
Karkempetzaki AI, Schatton T, Barthel SR.   +2 more
europepmc   +2 more sources

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

Nature Communications, 2021
Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism ...
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung   +16 more
doaj   +2 more sources

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins

Journal for ImmunoTherapy of Cancer, 2023
Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells.
Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev   +9 more
doaj   +2 more sources

A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Genes and Diseases, 2023
Over the past few decades, advances in immunological knowledge have led to the identification of novel immune checkpoints, reinvigorating cancer immunotherapy.
Yan Lv, Xiao Ma, Yuxin Ma, Yuxin Du, Jifeng Feng   +4 more
doaj   +2 more sources

The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis

Heliyon, 2023
Background: This study aimed to compare the salivary galectin-3 and galectin-9 levels in periodontitis, gingivitis, and periodontally healthy patients. Methods: This study included 75 non-smokers who were systemically healthy.
Zerrin Barut, Ahmet Mert Nalbantoğlu, Hilal Korkmaz, Zeynep Demir, Mükerrem Hatipoğlu, Aysun Özkan, Şule Bulut   +6 more
doaj   +2 more sources

The Dual Role of the NFATc2/galectin‐9 Axis in Modulating Tumor‐Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma

Advanced Science
Tumor‐initiating cells (TICs) resilience and an immunosuppressive microenvironment are aggressive oncogenic phenotypes that contribute to unsatisfactory long‐term outcomes in lung adenocarcinoma (LUAD) patients.
Zhi‐Jie Xiao, Si‐Qi Wang, Jun‐Jiang Chen, Yun Li, Yuchen Jiang, Vicky Pui‐Chi Tin, Jia Liu, Huiyi Hu, Maria Pik Wong, Yihang Pan, Judy Wai Ping Yam   +10 more
doaj   +2 more sources

Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target. [PDF]

Nat Commun
T-cell exhaustion contributes to immunotherapy failure in chronic lymphocytic leukemia (CLL). Here, we analyze T cells from CLL patients’ blood, bone marrow, and lymph nodes, as well as from a CLL mouse model, using single-cell RNA sequencing, mass ...
Llaó-Cid L, Wong J, Fernandez Botana I, Paul Y, Wierz M, Pilger LM, Floerchinger A, Tan CL, Gonder S, Pagano G, Chazotte M, Bestak K, Schifflers C, Iskar M, Roider T, Czernilofsky F, Bruch PM, Mallm JP, Cosma A, Campton DE, Gerhard-Hartmann E, Rosenwald A, Colomer D, Campo E, Schapiro D, Green EW, Dietrich S, Lichter P, Moussay E, Paggetti J, Zapatka M, Seiffert M.   +31 more
europepmc   +2 more sources