Results 21 to 30 of about 8,950,905 (317)

Microglia-derived Galectin-9 drives amyloid-β pathology in Alzheimer's disease. [PDF]

Aging Cell
The accumulation of amyloid‐β (Aβ) and overactivation of microglia contribute to the pathogenesis of Alzheimer's disease (AD), but the interaction between microglial activation and Aβ deposition in AD remains elusive.
Zhang G, Peng Q, Guo X, Pan L, Xiong M, Zhang X, Dai L, Zhang Z, Xiao T, He J, Liu M, Ke W, Zhang Z.   +12 more
europepmc   +2 more sources

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer [PDF]

Frontiers in Immunology, 2019
Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease.
Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev   +22 more
doaj   +2 more sources

Galectin-9 binds IgM-BCR to regulate B cell signaling [PDF]

Nature Communications, 2018
The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9.
Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko, Bebhinn Treanor   +11 more
doaj   +2 more sources

Alarmin function of galectin-9 in murine respiratory tularemia.

PLoS ONE, 2015
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis.
Anthony L Steichen, Tanner J Simonson, Sharon L Salmon, Dennis W Metzger, Bibhuti B Mishra, Jyotika Sharma   +5 more
doaj   +4 more sources

Galectin-9: diverse roles in skin disease. [PDF]

Front Allergy
Galectin-9 (Gal-9) is a multifunctional immunomodulatory molecule involved in cell growth, differentiation, adhesion, communication, and death. Galectin-9 mediates its physiological functions through interactions with multiple membrane receptors, including T-cell immunoglobulin mucin-domain containing-3 (Tim-3), immunoglobulin E, and the hyaluronan ...
Wang L, Zhang C, Ji J, Jiao Q.
europepmc   +4 more sources

Tim-3/galectin-9 regulates Th1/Th2 cell balance in lipopolysaccharide-induced human lymphocytes [PDF]

Jichu yixue yu linchuang, 2023
Objective To investigate the mechanism of Tim-3/galectin-9 in T helper type 1/2 (Th1/Th2) cell imbalance in lipopolysaccharide(LPS)-induced human lymphocytes.
SUN Xiaoli, ZHANG Jinjin, SONG Fengying, HUANG Yongli, CHEN Lili, XING Yanchao
doaj   +1 more source

Galectin-9 expression clinically associated with mature dendritic cells infiltration and T cell immune response in colorectal cancer

BMC Cancer, 2022
Background Galectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune microenvironment. However, the immunomodulatory effect of galectin-9 in colorectal cancer (CRC) remains
Yang Wang, Ruizhi Zheng, Yanhui Zhang, Yuhong Guo, Zhenzhen Hui, Peijing Wang, Yan Sun   +6 more
doaj   +1 more source

Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway. [PDF]

PLoS ONE, 2016
Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers.
Yang Wang, Jintang Sun, Chao Ma, Wenjuan Gao, Bingfeng Song, Hao Xue, Weiliang Chen, Xi Chen, Yun Zhang, Qianqian Shao, Qingjie Wang, Lei Zhao, Jia Liu, Xiuwen Wang, Huayang Wang, Yun Zhang, Meixiang Yang, Xun Qu   +17 more
doaj   +1 more source

Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?

Frontiers in Oncology, 2022
The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi, Yuanwei Shi, Danting Tang, Danting Tang, Xiaoqi Li, Xiaoqi Li, Xiaoli Xie, Yufu Ye, Yufu Ye, Lijuan Wang, Lijuan Wang   +10 more
doaj   +1 more source

Galectin-9 Is a Novel Regulator of Epithelial Restitution [PDF]

The American Journal of Pathology, 2020
Increasingly, the ß-galactoside binding lectins, termed galectins, are being recognized as critical regulators of cell function and organismal homeostasis. Within the context of the mucosal surface, galectins are established regulators of innate and adaptive immune responses, microbial populations, and several critical epithelial functions, including ...
Brian S. Robinson, Bejan Saeedi, Connie M. Arthur, Josh Owens, Crystal Naudin, Nourine Ahmed, Liping Luo, Rheinallt Jones, Andrew Neish, Sean R. Stowell   +9 more
openaire   +2 more sources