Results 41 to 50 of about 8,950,905 (317)

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]

, 2015
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson, Osman, AM, Salomonsson, E, Oliva Martín, María José, Annette Persson, Burguillos García, Miguel Ángel, Garcia-Quintanilla, Albert, Nikenza Viceconte, Englund, Elisabet,, Schulte, Tim, Elisabet Englund, Schulte, Tim,, Albert Garcia-Quintanilla, Kavanagh, Edel, Ahmed Mohamed Osman, Santiago, M, Joseph, Bertrand, García-Quintanilla, Alberto, Amar, Lahouari, Deierborg, Tomas,, Persson, A, Venero, Jose Luis, Blomgren, Klas, Englund, E, Leffler, H, Jose Luis Venero, Boza Serrano, Antonio, Burguillos, MA, García Quintanilla, Alberto, Martiniano Santiago, Antonio Boza-Serrano, Hakon Leffler, Joseph, B, Deierborg, Tomas, Englund, Elisabet, Persson, Annette,, Amar, L, Edel Kavanagh, Kavanagh, E, Lund University., Leffler, Hakon,, Emma Salomonsson, Venero, JL, Boza Serrano, Antonio,, Santiago, Martiniano, Venero Recio, José Luis, Amar, Lahouari,, Kavanagh, Edel T., Oliva-Martín, María J., Blomgren, K, Svensson, Martina,, Miguel Angel Burguillos, Viceconte, Nikenza, Bertrand Joseph, Salomonsson, Emma,, Oliva-Martin, Maria Jose, Svensson, Martina, Tim Schulte, Maria Jose Oliva-Martin, Osman, Ahmed Mohamed, Oliva-Martin, MJ, Boza-Serrano, A, Salomonsson, Emma, Persson, Annette, Achour, A, Garcia-Quintanilla, A, Adnane Achour, Achour, Adnane, Burguillos Garcia, Miguel, Viceconte, N, Burguillos Garcia, Miguel,, Santiago Pavón, Martiniano, Schulte, T, Tomas Deierborg, Svensson, M, Venero, José L., Klas Blomgren, Lahouari Amar, Deierborg, T, Burguillos, Miguel Angel, Leffler, Hakon, Boza-Serrano, Antonio   +81 more
core   +1 more source

Optimization of the inter-domain structure of galectin-9 for recombinant production [PDF]

, 2013
香川大学Kagawa University博士（医学）Abstract We previously developed a stable form of galectin-9, an immunomodulatory animal lectin with a truncated linker peptide (G9Null), to overcome the protease sensitivity of wild-type galectin-9.
Itoh, Aiko, イトウ, アイコ, 伊藤, 愛子   +2 more
core   +1 more source

Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2021
Background: Galectins, a family of β-galactoside-binding proteins, are related to the development and progression of various human diseases such as cancer, heart failure, and chronic kidney disease. However, its role in liver diseases is unclear.Methods:
Yang An, Yang An, Shixue Xu, Yiting Liu, Yiting Liu, Xiangbo Xu, Xiangbo Xu, Cyriac Abby Philips, Jiang Chen, Nahum Méndez-Sánchez, Xiaozhong Guo, Xingshun Qi   +11 more
doaj   +1 more source

Cancer Therapy Due to Apoptosis: Galectin-9 [PDF]

International Journal of Molecular Sciences, 2017
Dysregulation of apoptosis is a major hallmark in cancer biology that might equip tumors with a higher malignant potential and chemoresistance. The anti-cancer activities of lectin, defined as a carbohydrate-binding protein that is not an enzyme or antibody, have been investigated for over a century.
Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Eri Samukawa, Teppei Sakamoto, Takako Nomura, Joji Tani, Hirohito Yoneyama, Asahiro Morishita, Takashi Himoto, Mitsuomi Hirashima, Tsutomu Masaki   +12 more
openaire   +2 more sources

Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin

Frontiers in Cell and Developmental Biology, 2021
Galectin-14 is specifically expressed in placental trophoblasts, and its expression is reduced in trophoblasts retrieved from the cervix of women destined to develop early pregnancy loss.
Miaomiao Wang, Yuqing Xu, Peng Wang, Yanfei Xu, Pengzhen Jin, Zaigui Wu, Yeqing Qian, Yeqing Qian, Yeqing Qian, Long Bai, Long Bai, Minyue Dong, Minyue Dong, Minyue Dong   +13 more
doaj   +1 more source

Restriction of Human Cytomegalovirus Infection by Galectin-9 [PDF]

Journal of Virology, 2019
Human cytomegalovirus (HCMV) continues to cause serious and often life-threatening disease in those with impaired or underdeveloped immune systems. This virus is able to infect and replicate in a wide range of human cell types, which enables the virus to spread to other individuals in a number of settings.
Emily A. Machala, Selmir Avdic, Lauren Stern, Dirk M. Zajonc, Chris A. Benedict, Emily Blyth, David J. Gottlieb, Allison Abendroth, Brian P. McSharry, Barry Slobedman   +9 more
openaire   +2 more sources

EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis

Journal of Experimental & Clinical Cancer Research, 2018
Background Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC).
Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang, Hang Li   +10 more
doaj   +1 more source

Galectin-9 influences the Tim-3 molecule expression in natural killer different subpopulations

Медицинская иммунология, 2023
Galectin-9 is a b-galactoside binding lectin with expressed immunoregulatory activity. During pregnancy galectin-9 is produced by trophoblast cells and regulates the function of natural killer (NK) cells at the maternal-fetal interface via binding to Tim-
E. G. Orlova, O. A. Loginova, O. L. Gorbunova, S. V. Shirshev   +3 more
doaj   +1 more source

Galectin-9 promotes natural killer cells activity via interaction with CD44

Frontiers in Immunology, 2023
Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules. Their effector functions are tightly synchronized by the balance between the stimulatory and inhibitory receptors.
Amirhossein Rahmati, Steven Bigam, S. Elahi   +2 more
semanticscholar   +1 more source

Overexpression of miRNA-9 enhances galectin-3 levels in oral cavity cancers

, 2021
Oral cavity cancer (OCC) is the predominant subtype of head and neck cancer (HNC) and has up to 50% mortality. Genome-wide microRNA (miR) sequencing data indicates overexpression of miR-9-5p in HNC tumours, however, the biological role of miR-9-5p in OCC
Thompson, EW, Kenny, L, Blick, T, Tang, KD, Zhang, X, Wan, Y, Punyadeera, C   +6 more
core   +1 more source